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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MZF1
Z-value: 1.64
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Transcription factors associated with MZF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MZF1 | hg38_v1_chr19_-_58573280_58573354, hg38_v1_chr19_-_58573555_58573582 | 0.12 | 8.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MZF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.5 | 214.6 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 1.7 | 194.4 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 9.8 | 137.8 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 8.8 | 88.2 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 9.5 | 47.7 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 11.8 | 47.1 | GO:0032072 | plasmacytoid dendritic cell activation(GO:0002270) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426) |
| 1.1 | 40.3 | GO:0016574 | histone ubiquitination(GO:0016574) |
| 3.0 | 38.8 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.2 | 38.0 | GO:0051028 | mRNA transport(GO:0051028) |
| 7.5 | 37.5 | GO:0044375 | regulation of peroxisome size(GO:0044375) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.6 | 233.1 | GO:0005642 | annulate lamellae(GO:0005642) |
| 13.5 | 121.3 | GO:0097452 | GAIT complex(GO:0097452) |
| 0.6 | 121.1 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 4.3 | 82.5 | GO:0000812 | Swr1 complex(GO:0000812) |
| 0.3 | 66.3 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 7.3 | 65.4 | GO:0042382 | paraspeckles(GO:0042382) |
| 5.5 | 60.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.4 | 60.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 46.2 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.4 | 42.8 | GO:0005905 | clathrin-coated pit(GO:0005905) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.3 | 214.5 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
| 3.7 | 143.5 | GO:0008143 | poly(A) binding(GO:0008143) |
| 1.8 | 105.4 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 2.4 | 98.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.3 | 69.4 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.5 | 68.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.6 | 55.8 | GO:0070063 | RNA polymerase binding(GO:0070063) |
| 4.1 | 52.7 | GO:0000774 | adenyl-nucleotide exchange factor activity(GO:0000774) |
| 1.1 | 52.2 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 1.1 | 50.2 | GO:0046966 | thyroid hormone receptor binding(GO:0046966) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 214.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 2.5 | 86.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.7 | 75.8 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 3.0 | 56.8 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.7 | 51.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.6 | 50.3 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.8 | 48.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.5 | 47.3 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.9 | 46.5 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 1.2 | 43.5 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 218.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.9 | 93.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.5 | 83.2 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 2.5 | 50.9 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 3.1 | 47.1 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.9 | 46.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.8 | 39.6 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.5 | 36.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 1.5 | 36.3 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |
| 0.2 | 32.4 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |