Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for NFAT5
Z-value: 0.56
Motif logo
Transcription factors associated with NFAT5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFAT5 | hg38_v1_chr16_+_69566314_69566345 | 0.02 | 7.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFAT5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_59630806 Show fit | 9.63 |
ENST00000342503.8
|
reticulon 1 |
|
| chr14_-_59630582 Show fit | 9.20 |
ENST00000395090.5
|
reticulon 1 |
|
| chr7_+_149872955 Show fit | 8.42 |
ENST00000421974.7
ENST00000456496.7 |
ATPase H+ transporting V0 subunit e2 |
|
| chr10_+_3104676 Show fit | 7.72 |
ENST00000415005.6
ENST00000468050.1 |
phosphofructokinase, platelet |
|
| chr1_-_11654422 Show fit | 6.94 |
ENST00000354287.5
|
F-box protein 2 |
|
| chr11_-_111923722 Show fit | 6.66 |
ENST00000527950.5
|
crystallin alpha B |
|
| chr13_-_67230377 Show fit | 6.28 |
ENST00000544246.5
ENST00000377861.4 |
protocadherin 9 |
|
| chr14_+_100128573 Show fit | 6.16 |
ENST00000554695.5
|
Enah/Vasp-like |
|
| chr13_-_67230313 Show fit | 5.97 |
ENST00000377865.7
|
protocadherin 9 |
|
| chr7_-_101245032 Show fit | 4.96 |
ENST00000442303.1
|
fission, mitochondrial 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.0 | 9.9 | GO:1904579 | response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579) |
| 0.3 | 8.4 | GO:0015988 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) |
| 0.4 | 7.7 | GO:0006002 | fructose 6-phosphate metabolic process(GO:0006002) |
| 0.5 | 6.9 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.4 | 6.7 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.5 | 6.2 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 6.0 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 4.6 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.4 | 4.3 | GO:0008354 | germ cell migration(GO:0008354) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.1 | 11.4 | GO:0044291 | cell-cell contact zone(GO:0044291) |
| 0.4 | 9.9 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.5 | 8.4 | GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain(GO:0033177) proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.5 | 7.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 7.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.1 | 6.9 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 5.6 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.3 | 3.9 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.5 | 3.8 | GO:0036157 | outer dynein arm(GO:0036157) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 8.4 | GO:0046961 | ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 1.0 | 7.7 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.1 | 6.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.2 | 6.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 6.5 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.3 | 6.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.7 | 4.3 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.0 | 4.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 4.2 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 3.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 1.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.0 | 1.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 1.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.9 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 0.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.0 | 6.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.3 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 3.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 3.2 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.0 | 3.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 3.0 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.1 | 1.4 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.0 | 1.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.0 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |