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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFATC1

Z-value: 0.98

Motif logo

Transcription factors associated with NFATC1

Gene Symbol Gene ID Gene Info
ENSG00000131196.18 NFATC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFATC1hg38_v1_chr18_+_79400274_79400392-0.202.9e-03Click!

Activity profile of NFATC1 motif

Sorted Z-values of NFATC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_153544997 28.07 ENST00000368715.5
S100 calcium binding protein A4
chr5_+_136058849 15.72 ENST00000508076.5
transforming growth factor beta induced
chr5_+_136059151 15.40 ENST00000503087.1
transforming growth factor beta induced
chr2_-_160493799 13.20 ENST00000348849.8
RNA binding motif single stranded interacting protein 1
chr17_-_4949037 13.12 ENST00000572383.1
profilin 1
chr22_+_37675629 12.97 ENST00000215909.10
galectin 1
chr1_+_226063466 12.72 ENST00000666609.1
ENST00000661429.1
H3.3 histone A
chr3_+_152299570 12.26 ENST00000485910.5
ENST00000463374.5
muscleblind like splicing regulator 1
chr5_+_50666660 12.15 ENST00000515175.6
poly(ADP-ribose) polymerase family member 8
chr14_-_91946989 11.55 ENST00000556154.5
fibulin 5
chr6_-_79234713 11.36 ENST00000620514.1
high mobility group nucleosomal binding domain 3
chr6_+_32439866 11.28 ENST00000374982.5
ENST00000395388.7
major histocompatibility complex, class II, DR alpha
chr3_+_69084929 11.17 ENST00000273258.4
ADP ribosylation factor like GTPase 6 interacting protein 5
chr6_-_79234619 11.13 ENST00000344726.9
ENST00000275036.11
high mobility group nucleosomal binding domain 3
chr1_+_85580751 11.03 ENST00000451137.7
cellular communication network factor 1
chr2_+_188974364 10.71 ENST00000304636.9
ENST00000317840.9
collagen type III alpha 1 chain
chr17_-_4948519 10.36 ENST00000225655.6
profilin 1
chr1_-_153535984 10.30 ENST00000368719.9
ENST00000462776.2
S100 calcium binding protein A6
chr6_-_32953017 10.25 ENST00000395305.7
ENST00000374843.9
ENST00000395303.7
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
novel protein
chr12_+_49750598 9.94 ENST00000552370.5
transmembrane BAX inhibitor motif containing 6
chr3_+_69084973 9.69 ENST00000478935.1
ADP ribosylation factor like GTPase 6 interacting protein 5
chr10_-_119536533 9.67 ENST00000392865.5
regulator of G protein signaling 10
chr4_-_82844418 9.52 ENST00000503937.5
SEC31 homolog A, COPII coat complex component
chrX_+_103356446 8.56 ENST00000372656.5
ENST00000372661.6
ENST00000646896.1
transcription elongation factor A like 9
chr5_+_119354771 8.07 ENST00000503646.1
TNF alpha induced protein 8
chr12_-_50283472 8.03 ENST00000551691.5
ENST00000394943.7
ENST00000341247.8
LIM domain and actin binding 1
chr1_-_226739271 7.49 ENST00000429204.6
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr1_+_209768597 7.47 ENST00000487271.5
ENST00000477431.1
TRAF3 interacting protein 3
chr3_-_49411560 7.41 ENST00000679208.1
ras homolog family member A
chr10_+_22321056 7.38 ENST00000376663.8
BMI1 proto-oncogene, polycomb ring finger
chr11_+_18396266 7.33 ENST00000540430.5
ENST00000379412.9
lactate dehydrogenase A
chr12_-_50222348 7.20 ENST00000552823.5
ENST00000552909.5
LIM domain and actin binding 1
chr3_+_69763726 7.19 ENST00000448226.9
melanocyte inducing transcription factor
chr11_-_123059413 7.04 ENST00000524552.5
heat shock protein family A (Hsp70) member 8
chr10_+_11164961 6.98 ENST00000399850.7
ENST00000417956.6
CUGBP Elav-like family member 2
chr5_+_33440696 6.53 ENST00000502553.5
ENST00000514259.5
threonyl-tRNA synthetase 1
chr21_-_34526850 6.47 ENST00000481448.5
ENST00000381132.6
regulator of calcineurin 1
chr5_+_33440947 6.46 ENST00000455217.6
ENST00000265112.8
threonyl-tRNA synthetase 1
chr6_+_63211446 6.46 ENST00000370659.1
FKBP prolyl isomerase family member 1C
chr1_-_224433776 6.42 ENST00000678879.1
ENST00000651911.2
WD repeat domain 26
chr1_+_78649818 6.26 ENST00000370747.9
ENST00000438486.1
interferon induced protein 44
chr15_+_63529142 6.12 ENST00000268049.11
ubiquitin specific peptidase 3
chr17_-_7393404 6.06 ENST00000575434.4
phospholipid scramblase 3
chr2_+_86441341 5.98 ENST00000312912.10
ENST00000409064.5
lysine demethylase 3A
chr10_-_27154226 5.98 ENST00000427324.5
ENST00000375972.7
ENST00000326799.7
YME1 like 1 ATPase
chr1_-_244862381 5.87 ENST00000640001.1
ENST00000639628.1
heterogeneous nuclear ribonucleoprotein U
chr3_+_133574434 5.82 ENST00000508481.5
ENST00000420115.6
ENST00000504867.5
ENST00000507408.5
ENST00000511392.5
ENST00000515421.1
CDV3 homolog
chr22_-_42959852 5.82 ENST00000402229.5
ENST00000407585.5
ENST00000453079.1
protein kinase C and casein kinase substrate in neurons 2
chr10_-_27154365 5.78 ENST00000396296.7
ENST00000376016.8
ENST00000491542.6
ENST00000613434.4
YME1 like 1 ATPase
chr10_-_26860975 5.57 ENST00000376166.5
ENST00000346832.10
ENST00000376138.7
ENST00000536334.5
ENST00000490841.6
ENST00000376137.8
abl interactor 1
chr2_-_229921316 5.45 ENST00000428959.5
ENST00000675423.1
thyroid hormone receptor interactor 12
chr10_-_26860922 5.39 ENST00000376142.6
ENST00000359188.8
ENST00000376140.4
ENST00000376139.6
ENST00000376160.5
abl interactor 1
chr4_-_70666492 5.39 ENST00000254801.9
ENST00000391614.7
joining chain of multimeric IgA and IgM
chr19_+_16111868 5.34 ENST00000300935.8
ENST00000586682.1
RAB8A, member RAS oncogene family
chr10_+_102776237 5.19 ENST00000369889.5
WW domain binding protein 1 like
chr1_-_94237562 5.18 ENST00000260526.11
ENST00000370217.3
Rho GTPase activating protein 29
chr11_-_123058991 5.17 ENST00000526686.1
heat shock protein family A (Hsp70) member 8
chr17_-_31321603 5.16 ENST00000462804.3
ecotropic viral integration site 2A
chrX_+_41333905 5.15 ENST00000457138.7
ENST00000643821.1
DEAD-box helicase 3 X-linked
chr10_-_26860888 5.11 ENST00000376170.8
abl interactor 1
chr12_+_51238724 5.02 ENST00000449723.7
ENST00000549555.5
ENST00000439799.6
ENST00000412716.8
ENST00000425012.6
DAZ associated protein 2
chr14_-_91947383 4.95 ENST00000267620.14
fibulin 5
chr14_-_35121950 4.93 ENST00000554361.5
ENST00000261475.10
protein phosphatase 2 regulatory subunit B''gamma
chr1_+_167329044 4.93 ENST00000367862.9
POU class 2 homeobox 1
chrX_+_41334154 4.91 ENST00000441189.4
ENST00000644513.1
ENST00000644109.1
ENST00000646122.1
ENST00000644074.1
ENST00000644876.2
ENST00000399959.7
ENST00000646319.1
DEAD-box helicase 3 X-linked
chr1_+_11934651 4.89 ENST00000449038.5
ENST00000196061.5
ENST00000429000.6
procollagen-lysine,2-oxoglutarate 5-dioxygenase 1
chr3_-_120093666 4.87 ENST00000316626.6
ENST00000650344.2
ENST00000678439.1
glycogen synthase kinase 3 beta
chr12_+_96194365 4.83 ENST00000228741.8
ENST00000547249.1
ETS transcription factor ELK3
chr1_+_81800906 4.82 ENST00000674393.1
ENST00000674208.1
adhesion G protein-coupled receptor L2
chr12_-_123272234 4.79 ENST00000544658.5
cyclin dependent kinase 2 associated protein 1
chr17_-_31321743 4.72 ENST00000247270.3
ecotropic viral integration site 2A
chr2_-_157874976 4.63 ENST00000682025.1
ENST00000683487.1
ENST00000682300.1
ENST00000683441.1
ENST00000684595.1
ENST00000683426.1
ENST00000683820.1
ENST00000263640.7
activin A receptor type 1
chr13_-_98521998 4.56 ENST00000376547.7
serine/threonine kinase 24
chr1_+_155208690 4.52 ENST00000368376.8
metaxin 1
chr7_+_142791635 4.50 ENST00000633705.1
T cell receptor beta constant 1
chr12_-_123271803 4.43 ENST00000261692.7
cyclin dependent kinase 2 associated protein 1
chr9_-_14314519 4.38 ENST00000397581.6
nuclear factor I B
chr1_-_150808251 4.36 ENST00000271651.8
ENST00000676970.1
ENST00000679260.1
ENST00000676751.1
ENST00000677887.1
cathepsin K
chr10_+_110964125 4.32 ENST00000265277.9
SHOC2 leucine rich repeat scaffold protein
chr5_+_50666917 4.07 ENST00000514342.6
poly(ADP-ribose) polymerase family member 8
chr17_+_28720552 4.06 ENST00000472628.1
ENST00000578181.1
ribosomal protein L23a
chr9_-_14314567 3.98 ENST00000397579.6
nuclear factor I B
chr10_-_63269057 3.90 ENST00000542921.5
jumonji domain containing 1C
chr14_-_89417148 3.88 ENST00000557258.6
forkhead box N3
chr18_-_55422492 3.88 ENST00000561992.5
ENST00000630712.2
transcription factor 4
chr9_-_36276967 3.79 ENST00000396594.8
ENST00000543356.7
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
chr9_+_121299793 3.78 ENST00000373818.8
gelsolin
chr1_+_1013485 3.76 ENST00000649529.1
ISG15 ubiquitin like modifier
chr1_-_43172504 3.61 ENST00000431635.6
EBNA1 binding protein 2
chr12_-_55958582 3.61 ENST00000549404.5
premelanosome protein
chr13_-_75482114 3.58 ENST00000377625.6
ENST00000431480.6
TBC1 domain family member 4
chr7_-_29146436 3.57 ENST00000396276.7
carboxypeptidase vitellogenic like
chr4_-_103099811 3.56 ENST00000504285.5
ENST00000296424.9
3-hydroxybutyrate dehydrogenase 2
chr1_+_171512032 3.52 ENST00000426496.6
proline rich coiled-coil 2C
chr3_-_142028597 3.47 ENST00000467667.5
transcription factor Dp-2
chr6_+_15246054 3.46 ENST00000341776.7
jumonji and AT-rich interaction domain containing 2
chr8_+_127736220 3.42 ENST00000524013.2
ENST00000621592.8
MYC proto-oncogene, bHLH transcription factor
chr2_-_162242998 3.37 ENST00000627638.2
ENST00000447386.5
fibroblast activation protein alpha
chr13_-_75482151 3.32 ENST00000377636.8
TBC1 domain family member 4
chr15_-_59689283 3.30 ENST00000607373.6
ENST00000612191.4
ENST00000267859.8
BCL2 interacting protein 2
chr3_-_79019444 3.29 ENST00000618833.4
ENST00000436010.6
ENST00000618846.4
roundabout guidance receptor 1
chr19_+_39406831 3.28 ENST00000597629.3
ENST00000594442.2
ENST00000594045.2
ZFP36 ring finger protein
chr14_+_90398159 3.27 ENST00000544280.6
calmodulin 1
chr5_+_140401808 3.26 ENST00000616482.4
ENST00000297183.10
ENST00000360839.7
ENST00000421134.5
ENST00000394723.7
ENST00000511151.5
ankyrin repeat and KH domain containing 1
chr8_-_133060347 3.24 ENST00000427060.6
Src like adaptor
chr17_+_51260520 3.24 ENST00000225298.12
UTP18 small subunit processome component
chr17_-_41521719 3.10 ENST00000393976.6
keratin 15
chr6_-_11232658 3.10 ENST00000379433.5
ENST00000379446.10
ENST00000620854.4
neural precursor cell expressed, developmentally down-regulated 9
chr12_+_98593591 2.98 ENST00000401722.7
ENST00000188376.9
ENST00000551917.5
ENST00000551265.5
ENST00000550695.1
ENST00000547534.5
ENST00000228318.8
ENST00000552981.6
ENST00000549338.5
ENST00000548847.1
solute carrier family 25 member 3
chrX_+_9560465 2.95 ENST00000647060.1
transducin beta like 1 X-linked
chr5_+_136160986 2.95 ENST00000507637.1
SMAD family member 5
chr15_-_32455634 2.93 ENST00000509311.7
golgin A8 family member O
chr15_+_30604028 2.90 ENST00000566740.2
golgin A8 family member H
chr4_-_177442427 2.83 ENST00000264595.7
aspartylglucosaminidase
chr12_-_91179472 2.82 ENST00000550099.5
ENST00000546391.5
decorin
chr8_+_97887903 2.82 ENST00000520016.5
matrilin 2
chr17_+_28719995 2.77 ENST00000496182.5
ribosomal protein L23a
chr18_-_55587335 2.75 ENST00000638154.3
transcription factor 4
chr11_-_102798148 2.71 ENST00000315274.7
matrix metallopeptidase 1
chrX_-_130110679 2.71 ENST00000335997.11
E74 like ETS transcription factor 4
chr8_-_94262308 2.70 ENST00000297596.3
ENST00000396194.6
GTP binding protein overexpressed in skeletal muscle
chr12_+_26195647 2.69 ENST00000535504.1
sarcospan
chr1_+_81800368 2.66 ENST00000674489.1
ENST00000674442.1
ENST00000674419.1
ENST00000674407.1
ENST00000674168.1
ENST00000674307.1
ENST00000674209.1
ENST00000370715.5
ENST00000370713.5
ENST00000319517.10
ENST00000627151.2
ENST00000370717.6
adhesion G protein-coupled receptor L2
chr18_-_55422306 2.64 ENST00000566777.5
ENST00000626584.2
transcription factor 4
chr7_+_100602344 2.60 ENST00000223061.6
procollagen C-endopeptidase enhancer
chr15_+_32593456 2.57 ENST00000448387.6
ENST00000569659.5
golgin A8 family member N
chrX_+_153494970 2.52 ENST00000331595.9
ENST00000431891.1
biglycan
chr17_-_41586887 2.51 ENST00000167586.7
keratin 14
chr17_+_44345291 2.49 ENST00000593167.5
ENST00000585512.5
ENST00000591740.5
ENST00000592783.5
ENST00000587387.5
ENST00000588237.5
ENST00000053867.8
ENST00000589265.5
granulin precursor
chr12_-_91179517 2.49 ENST00000551354.1
decorin
chr9_-_129835232 2.42 ENST00000372447.7
chromosome 9 open reading frame 78
chr1_+_155208727 2.40 ENST00000316721.8
metaxin 1
chr11_-_110296605 2.39 ENST00000534683.1
ENST00000647231.1
ENST00000645495.2
radixin
chr19_+_10086787 2.38 ENST00000590378.5
ENST00000397881.7
shiftless antiviral inhibitor of ribosomal frameshifting
chr17_-_35880350 2.38 ENST00000605140.6
ENST00000651122.1
ENST00000603197.6
C-C motif chemokine ligand 5
chr18_+_58255433 2.36 ENST00000635997.1
NEDD4 like E3 ubiquitin protein ligase
chr8_-_13514821 2.36 ENST00000276297.9
DLC1 Rho GTPase activating protein
chr10_-_103452384 2.35 ENST00000369788.7
calcium homeostasis modulator family member 2
chr17_+_47522931 2.35 ENST00000525007.5
ENST00000530173.6
aminopeptidase puromycin sensitive
chr18_+_58149314 2.33 ENST00000435432.6
ENST00000357895.9
ENST00000586263.5
NEDD4 like E3 ubiquitin protein ligase
chr5_+_50666950 2.31 ENST00000513738.5
ENST00000503665.5
ENST00000514067.6
ENST00000503046.5
poly(ADP-ribose) polymerase family member 8
chr6_-_43627302 2.30 ENST00000307114.11
GTP binding protein 2
chr18_-_55321640 2.29 ENST00000637169.2
transcription factor 4
chr1_-_11926385 2.29 ENST00000616327.1
ENST00000376572.8
ENST00000376576.3
KIAA2013
chr11_+_36594369 2.29 ENST00000678060.1
ENST00000446510.6
ENST00000676979.1
ENST00000677808.1
ENST00000617650.5
ENST00000334307.10
ENST00000531554.6
ENST00000679022.1
ENST00000347206.8
ENST00000534635.5
ENST00000676921.1
ENST00000678950.1
ENST00000530697.6
ENST00000527108.6
ENST00000532470.3
intraflagellar transport associated protein
chr3_-_183099577 2.28 ENST00000610757.4
ENST00000629669.2
methylcrotonoyl-CoA carboxylase 1
chr1_-_186680411 2.28 ENST00000367468.10
prostaglandin-endoperoxide synthase 2
chr3_-_50322759 2.26 ENST00000442581.1
ENST00000447092.5
hyaluronidase 2
chr10_-_103452356 2.22 ENST00000260743.10
calcium homeostasis modulator family member 2
chr3_-_158672612 2.22 ENST00000264265.4
latexin
chr3_+_130850585 2.22 ENST00000505330.5
ENST00000504381.5
ENST00000507488.6
ATPase secretory pathway Ca2+ transporting 1
chr17_-_37609361 2.17 ENST00000614941.4
ENST00000619541.4
ENST00000622045.4
ENST00000616179.4
ENST00000621136.4
ENST00000612223.5
ENST00000620424.1
synergin gamma
chr18_-_55321986 2.16 ENST00000570287.6
transcription factor 4
chr18_-_55589770 2.06 ENST00000565018.6
ENST00000636400.2
transcription factor 4
chr12_-_7503841 2.05 ENST00000359156.8
CD163 molecule
chr1_-_103108468 2.03 ENST00000512756.5
ENST00000461720.6
ENST00000358392.6
ENST00000353414.8
collagen type XI alpha 1 chain
chr1_-_103108512 2.02 ENST00000370096.9
ENST00000647280.1
ENST00000644186.1
collagen type XI alpha 1 chain
chr3_-_183099464 2.00 ENST00000265594.9
methylcrotonoyl-CoA carboxylase 1
chr17_-_51046868 1.99 ENST00000510283.5
ENST00000510855.1
sperm associated antigen 9
chr5_+_179698367 1.97 ENST00000680406.1
ENST00000502296.6
ENST00000504734.5
calnexin
chr19_+_10106223 1.91 ENST00000428358.5
PPAN-P2RY11 readthrough
chr7_-_151520080 1.90 ENST00000496004.5
Ras homolog, mTORC1 binding
chr16_+_1533654 1.88 ENST00000566264.2
transmembrane protein 204
chr16_-_30445865 1.85 ENST00000478753.5
selenophosphate synthetase 2
chr1_+_155209213 1.83 ENST00000609421.1
metaxin 1
chr5_+_140401860 1.83 ENST00000532219.5
ENST00000394722.7
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr2_-_162243375 1.83 ENST00000188790.9
ENST00000443424.5
fibroblast activation protein alpha
chr12_-_7503744 1.81 ENST00000396620.7
ENST00000432237.3
CD163 molecule
chr1_-_77219399 1.79 ENST00000359130.1
ENST00000370812.8
ENST00000445065.5
phosphatidylinositol glycan anchor biosynthesis class K
chr2_-_96870034 1.79 ENST00000305476.10
semaphorin 4C
chr11_-_110296701 1.77 ENST00000528498.5
ENST00000528900.5
ENST00000530301.5
ENST00000544551.5
radixin
chr17_-_15260752 1.75 ENST00000676329.1
ENST00000675551.1
ENST00000644020.1
ENST00000674947.1
peripheral myelin protein 22
chr1_-_26900437 1.73 ENST00000361720.10
G-patch domain containing 3
chr1_-_155910881 1.71 ENST00000609492.1
ENST00000368322.7
Ras like without CAAX 1
chr17_+_34255274 1.68 ENST00000580907.5
ENST00000225831.4
C-C motif chemokine ligand 2
chr21_+_38805165 1.68 ENST00000360214.8
ETS proto-oncogene 2, transcription factor
chr7_+_139829242 1.64 ENST00000455353.6
ENST00000458722.6
ENST00000448866.7
ENST00000411653.6
thromboxane A synthase 1
chr18_-_55589795 1.63 ENST00000568740.5
ENST00000629387.2
transcription factor 4
chr12_+_93572664 1.61 ENST00000551556.2
suppressor of cytokine signaling 2
chr8_+_94641199 1.56 ENST00000646773.1
ENST00000454170.7
epithelial splicing regulatory protein 1
chr5_+_7869104 1.52 ENST00000264668.6
ENST00000514220.5
ENST00000440940.7
ENST00000502550.5
ENST00000506877.1
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
chr5_+_50666612 1.51 ENST00000281631.10
poly(ADP-ribose) polymerase family member 8
chr5_-_7868995 1.51 ENST00000264669.10
ENST00000507572.1
ENST00000504695.1
FAST kinase domains 3
chr8_+_94641145 1.48 ENST00000433389.8
ENST00000358397.9
epithelial splicing regulatory protein 1
chr11_-_14337074 1.47 ENST00000531421.5
RAS related 2
chr3_-_15797930 1.47 ENST00000683139.1
ankyrin repeat domain 28
chr5_+_50667405 1.43 ENST00000505554.5
poly(ADP-ribose) polymerase family member 8
chr10_+_3104676 1.42 ENST00000415005.6
ENST00000468050.1
phosphofructokinase, platelet
chr1_-_159714581 1.42 ENST00000255030.9
ENST00000437342.1
ENST00000368112.5
ENST00000368111.5
ENST00000368110.1
C-reactive protein
chr2_+_1413456 1.38 ENST00000539820.5
ENST00000382269.7
ENST00000345913.8
ENST00000329066.9
ENST00000382201.7
thyroid peroxidase
chr4_-_38804783 1.37 ENST00000308979.7
ENST00000505940.1
ENST00000515861.5
toll like receptor 1
chr12_-_52493250 1.35 ENST00000330722.7
keratin 6A
chr17_-_41624541 1.33 ENST00000540235.5
ENST00000311208.13
keratin 17
chr18_-_55510753 1.31 ENST00000543082.5
transcription factor 4
chr1_+_162790702 1.30 ENST00000254521.8
ENST00000367915.1
hydroxysteroid 17-beta dehydrogenase 7
chr17_+_41255384 1.29 ENST00000394008.1
keratin associated protein 9-9
chr3_-_36945042 1.28 ENST00000645898.2
ENST00000429976.5
tetratricopeptide repeat and ankyrin repeat containing 1
chr3_-_15440560 1.26 ENST00000595627.5
ENST00000597949.1
ENST00000494875.3
ENST00000595975.1
ENST00000598878.1
EAF1 antisense RNA 1
methyltransferase like 6
chr18_-_55322215 1.25 ENST00000457482.7
transcription factor 4
chr1_+_84408230 1.25 ENST00000370662.3
deoxyribonuclease 2 beta

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.2 21.5 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
3.2 13.0 GO:0002317 plasma cell differentiation(GO:0002317)
3.2 19.0 GO:0002036 regulation of L-glutamate transport(GO:0002036)
2.4 12.2 GO:1902904 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
2.0 6.0 GO:0046292 formaldehyde metabolic process(GO:0046292)
2.0 5.9 GO:1904339 negative regulation of dopaminergic neuron differentiation(GO:1904339)
1.9 7.4 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
1.8 23.5 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
1.8 10.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
1.7 9.9 GO:0031438 negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.5 4.6 GO:0060957 endocardial cell fate commitment(GO:0060957) endocardial cushion cell fate commitment(GO:0061445)
1.5 11.8 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
1.4 16.5 GO:0048251 elastic fiber assembly(GO:0048251)
1.3 5.2 GO:0097325 melanocyte proliferation(GO:0097325)
1.3 10.1 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
1.2 4.9 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.1 7.5 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.9 2.7 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.9 4.4 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.9 3.4 GO:0090095 metanephric cap development(GO:0072185) metanephric cap morphogenesis(GO:0072186) metanephric cap mesenchymal cell proliferation involved in metanephros development(GO:0090094) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.8 3.3 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.8 3.3 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245)
0.8 5.4 GO:1902915 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
0.8 8.4 GO:0021740 trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.8 2.3 GO:0031394 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8 3.8 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.7 4.2 GO:0032487 regulation of Rap protein signal transduction(GO:0032487)
0.7 3.5 GO:0070295 renal water absorption(GO:0070295)
0.6 2.6 GO:0072683 T cell extravasation(GO:0072683)
0.6 6.8 GO:0007379 segment specification(GO:0007379)
0.6 4.9 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
0.6 9.5 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.6 2.4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.6 13.7 GO:0035855 megakaryocyte development(GO:0035855)
0.6 5.8 GO:0070836 caveola assembly(GO:0070836)
0.5 3.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.5 4.1 GO:0035989 tendon development(GO:0035989)
0.5 9.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 3.8 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 7.8 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.5 7.3 GO:0006089 lactate metabolic process(GO:0006089)
0.5 4.1 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.5 1.4 GO:0042494 detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.5 1.4 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.4 5.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.4 2.9 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 2.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 2.5 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 0.7 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.3 2.4 GO:2000768 positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.3 6.1 GO:0017121 phospholipid scrambling(GO:0017121)
0.3 3.6 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.3 3.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 5.3 GO:0098969 neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
0.3 0.9 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.3 1.5 GO:0043418 homocysteine catabolic process(GO:0043418)
0.3 0.9 GO:1904742 regulation of telomeric DNA binding(GO:1904742)
0.3 15.2 GO:0031529 ruffle organization(GO:0031529)
0.3 2.0 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.3 0.3 GO:0038129 ERBB3 signaling pathway(GO:0038129)
0.3 2.5 GO:0006552 leucine catabolic process(GO:0006552)
0.2 22.5 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.2 3.5 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.2 0.7 GO:0003274 endocardial cushion fusion(GO:0003274)
0.2 1.7 GO:0001712 ectoderm formation(GO:0001705) ectodermal cell fate commitment(GO:0001712)
0.2 9.9 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 1.8 GO:0001887 selenium compound metabolic process(GO:0001887)
0.2 1.8 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 0.9 GO:2000653 regulation of genetic imprinting(GO:2000653)
0.2 1.1 GO:0035988 chondrocyte proliferation(GO:0035988)
0.2 0.6 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.2 3.8 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 26.1 GO:0002062 chondrocyte differentiation(GO:0002062)
0.2 3.9 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.2 3.9 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 6.1 GO:0016578 histone deubiquitination(GO:0016578)
0.2 4.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 1.1 GO:1902730 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.2 7.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 9.7 GO:0048146 positive regulation of fibroblast proliferation(GO:0048146)
0.1 1.0 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.1 1.3 GO:0001866 NK T cell proliferation(GO:0001866)
0.1 22.9 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 1.3 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.1 5.2 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 6.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.8 GO:0032060 bleb assembly(GO:0032060)
0.1 5.2 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1 0.8 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 2.0 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 2.2 GO:0050965 detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965)
0.1 1.4 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.1 4.3 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.1 4.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 8.1 GO:0045445 myoblast differentiation(GO:0045445)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 22.3 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.1 1.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.3 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 3.2 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 1.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.1 1.9 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 1.4 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.1 3.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.7 GO:0002076 osteoblast development(GO:0002076)
0.1 2.8 GO:0008347 glial cell migration(GO:0008347)
0.1 2.9 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.1 0.7 GO:0048007 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.9 GO:0040033 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.4 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 1.9 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
0.1 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629) negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.1 4.5 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 4.9 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.1 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 8.6 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 2.1 GO:0032438 melanosome organization(GO:0032438)
0.1 0.7 GO:0060117 auditory receptor cell development(GO:0060117)
0.1 0.3 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 2.3 GO:0043171 peptide catabolic process(GO:0043171)
0.0 1.2 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 8.6 GO:0006260 DNA replication(GO:0006260)
0.0 3.4 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.8 GO:0055070 copper ion homeostasis(GO:0055070)
0.0 1.9 GO:0006953 acute-phase response(GO:0006953)
0.0 2.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.9 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.0 0.4 GO:0043586 tongue development(GO:0043586)
0.0 1.8 GO:0032760 positive regulation of tumor necrosis factor production(GO:0032760)
0.0 0.2 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.8 GO:0061512 protein localization to cilium(GO:0061512)
0.0 1.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.8 GO:0000281 mitotic cytokinesis(GO:0000281)
0.0 2.0 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.5 GO:0051017 actin filament bundle assembly(GO:0051017)
0.0 1.2 GO:0016575 histone deacetylation(GO:0016575)
0.0 1.0 GO:0007062 sister chromatid cohesion(GO:0007062)
0.0 0.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 16.5 GO:0071953 elastic fiber(GO:0071953)
1.8 5.4 GO:0071752 dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756)
1.5 12.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.4 4.1 GO:0005592 collagen type XI trimer(GO:0005592)
1.2 16.1 GO:0031209 SCAR complex(GO:0031209)
1.2 4.6 GO:0048179 activin receptor complex(GO:0048179)
1.1 21.5 GO:0042613 MHC class II protein complex(GO:0042613)
1.1 10.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 3.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.6 4.4 GO:0036021 endolysosome lumen(GO:0036021)
0.5 9.5 GO:0030127 COPII vesicle coat(GO:0030127)
0.5 7.4 GO:0035102 PRC1 complex(GO:0035102)
0.5 1.4 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.4 1.8 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.4 6.1 GO:0070938 contractile ring(GO:0070938)
0.4 4.2 GO:0051286 cell tip(GO:0051286)
0.4 5.3 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.4 8.1 GO:0031932 TORC2 complex(GO:0031932)
0.4 5.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.4 10.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 5.2 GO:0071438 invadopodium membrane(GO:0071438)
0.3 5.9 GO:1990909 Wnt signalosome(GO:1990909)
0.3 22.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.3 2.5 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
0.3 2.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 4.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 29.5 GO:0005604 basement membrane(GO:0005604)
0.2 3.3 GO:0005845 mRNA cap binding complex(GO:0005845)
0.2 2.7 GO:0030478 actin cap(GO:0030478)
0.2 0.9 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.2 5.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 3.8 GO:0071141 SMAD protein complex(GO:0071141)
0.2 3.6 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 5.5 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 1.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 4.9 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.2 3.5 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 10.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.4 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 2.0 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 25.3 GO:0072562 blood microparticle(GO:0072562)
0.1 0.9 GO:0035976 AP1 complex(GO:0035976)
0.1 0.9 GO:0070187 telosome(GO:0070187)
0.1 18.4 GO:0032993 protein-DNA complex(GO:0032993)
0.1 2.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 2.1 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 2.4 GO:0051233 spindle midzone(GO:0051233)
0.1 1.8 GO:0043218 compact myelin(GO:0043218)
0.1 3.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 8.9 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.4 GO:0016012 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0 1.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 2.7 GO:0005876 spindle microtubule(GO:0005876)
0.0 6.4 GO:0000922 spindle pole(GO:0000922)
0.0 5.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 21.5 GO:0000785 chromatin(GO:0000785)
0.0 7.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 27.3 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 1.1 GO:0032420 stereocilium(GO:0032420)
0.0 4.8 GO:0005819 spindle(GO:0005819)
0.0 1.2 GO:0016235 aggresome(GO:0016235)
0.0 19.8 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.3 GO:0035861 site of double-strand break(GO:0035861)
0.0 3.9 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 1.3 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0016605 PML body(GO:0016605)
0.0 9.0 GO:0016607 nuclear speck(GO:0016607)
0.0 1.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.3 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 6.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 0.8 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.1 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 1.4 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.7 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 13.0 GO:0048030 disaccharide binding(GO:0048030)
4.1 12.3 GO:0001069 regulatory region RNA binding(GO:0001069)
2.5 10.1 GO:0043273 CTPase activity(GO:0043273)
1.9 7.5 GO:0016524 latrotoxin receptor activity(GO:0016524)
1.8 23.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
1.5 11.8 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
1.4 9.9 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
1.3 28.1 GO:0050786 RAGE receptor binding(GO:0050786)
1.2 4.9 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
1.2 3.6 GO:0003858 3-hydroxybutyrate dehydrogenase activity(GO:0003858)
1.1 33.7 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.1 5.4 GO:0019862 IgA binding(GO:0019862)
1.1 7.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.1 7.4 GO:0051022 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
1.1 7.4 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
1.0 7.3 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
1.0 21.1 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 2.6 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.8 10.7 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.8 4.6 GO:0016361 activin receptor activity, type I(GO:0016361)
0.7 31.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.6 2.5 GO:1990254 keratin filament binding(GO:1990254)
0.6 5.2 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.6 2.3 GO:0050473 arachidonate 15-lipoxygenase activity(GO:0050473)
0.6 21.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.5 1.6 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.5 1.9 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 2.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.5 3.8 GO:0045159 myosin II binding(GO:0045159)
0.5 10.3 GO:0044548 S100 protein binding(GO:0044548)
0.5 1.4 GO:0035663 Toll-like receptor 2 binding(GO:0035663)
0.5 2.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
0.4 1.8 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.4 1.3 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 1.2 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.4 15.3 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 35.8 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 3.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 1.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.4 6.1 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.4 1.1 GO:1902271 D3 vitamins binding(GO:1902271)
0.4 15.2 GO:0003785 actin monomer binding(GO:0003785)
0.4 10.1 GO:0070182 DNA polymerase binding(GO:0070182)
0.4 1.4 GO:0033265 choline binding(GO:0033265)
0.4 6.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 4.6 GO:0001968 fibronectin binding(GO:0001968)
0.3 9.7 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 2.5 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
0.3 13.6 GO:0050699 WW domain binding(GO:0050699)
0.3 1.4 GO:0004447 iodide peroxidase activity(GO:0004447)
0.3 3.8 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.3 3.8 GO:0031386 protein tag(GO:0031386)
0.3 3.8 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.2 5.8 GO:0070300 phosphatidic acid binding(GO:0070300)
0.2 3.6 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 5.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.2 4.6 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 3.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 5.3 GO:0031489 myosin V binding(GO:0031489)
0.2 5.9 GO:0070034 telomerase RNA binding(GO:0070034)
0.2 1.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.2 5.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 3.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.2 5.1 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 1.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 1.4 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.2 2.0 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.2 8.2 GO:0070888 E-box binding(GO:0070888)
0.1 0.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 3.5 GO:0032452 histone demethylase activity(GO:0032452)
0.1 2.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 5.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 1.0 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 5.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.5 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.1 9.9 GO:0019843 rRNA binding(GO:0019843)
0.1 1.3 GO:0032395 MHC class II receptor activity(GO:0032395)
0.1 4.3 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 2.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 13.4 GO:0005178 integrin binding(GO:0005178)
0.1 0.3 GO:0031626 beta-endorphin binding(GO:0031626)
0.1 4.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.9 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 13.2 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 2.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 0.7 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 4.5 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 6.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 4.2 GO:0051018 protein kinase A binding(GO:0051018)
0.1 1.1 GO:0038191 neuropilin binding(GO:0038191)
0.1 1.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 3.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 3.5 GO:0019003 GDP binding(GO:0019003)
0.0 2.6 GO:0016504 peptidase activator activity(GO:0016504)
0.0 2.8 GO:0043621 protein self-association(GO:0043621)
0.0 3.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.5 GO:0042805 actinin binding(GO:0042805)
0.0 0.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 1.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.8 GO:0005507 copper ion binding(GO:0005507)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 31.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.6 7.5 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.5 37.3 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.4 8.5 PID ALK2 PATHWAY ALK2 signaling events
0.3 32.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 14.3 NABA COLLAGENS Genes encoding collagen proteins
0.3 10.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.3 10.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 30.9 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 11.2 PID RAS PATHWAY Regulation of Ras family activation
0.2 11.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 10.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 12.9 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 15.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 6.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.9 PID RHOA PATHWAY RhoA signaling pathway
0.1 12.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 14.1 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 1.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 4.6 PID E2F PATHWAY E2F transcription factor network
0.1 20.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 2.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.0 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 4.1 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 2.3 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 0.7 PID BMP PATHWAY BMP receptor signaling
0.0 3.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.8 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 0.3 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 31.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.5 26.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 11.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3 24.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 7.4 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 4.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.3 19.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 7.8 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.3 12.2 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.2 2.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 7.3 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.2 3.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 4.2 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 3.3 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 3.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 8.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 7.7 REACTOME RNA POL III TRANSCRIPTION Genes involved in RNA Polymerase III Transcription
0.1 1.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 2.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 0.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 10.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 3.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 4.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1 2.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 3.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 1.7 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 1.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 1.7 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.1 0.9 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
0.1 1.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.8 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 8.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 6.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 0.9 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.0 1.0 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 2.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks