Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for NFE2L1
Z-value: 0.87
Motif logo
Transcription factors associated with NFE2L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L1 | hg38_v1_chr17_+_48048773_48048790 | -0.07 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFE2L1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_7916280 Show fit | 10.92 |
ENST00000324348.9
|
ring finger protein 227 |
|
| chr17_-_7915929 Show fit | 7.85 |
ENST00000635932.1
ENST00000640240.1 |
ring finger protein 227 |
|
| chr18_+_657637 Show fit | 7.67 |
ENST00000323274.15
|
thymidylate synthetase |
|
| chr18_+_657734 Show fit | 7.48 |
ENST00000323250.9
ENST00000323224.7 |
thymidylate synthetase |
|
| chr2_+_233636445 Show fit | 6.87 |
ENST00000344644.9
|
UDP glucuronosyltransferase family 1 member A10 |
|
| chr2_+_233693659 Show fit | 6.62 |
ENST00000406651.1
|
UDP glucuronosyltransferase family 1 member A6 |
|
| chr11_+_35176639 Show fit | 5.76 |
ENST00000527889.6
|
CD44 molecule (Indian blood group) |
|
| chr5_+_160421847 Show fit | 5.60 |
ENST00000352433.10
ENST00000517480.1 ENST00000520452.5 ENST00000393964.1 |
PTTG1 regulator of sister chromatid separation, securin |
|
| chr9_+_122264857 Show fit | 5.26 |
ENST00000344641.8
ENST00000441707.5 ENST00000373723.9 ENST00000373729.5 |
mitochondrial ribosome recycling factor |
|
| chr12_-_52493250 Show fit | 5.24 |
ENST00000330722.7
|
keratin 6A |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 32.9 | GO:1900625 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 3.2 | 22.7 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 3.8 | 15.2 | GO:0019860 | uracil metabolic process(GO:0019860) |
| 0.1 | 11.9 | GO:0031424 | keratinization(GO:0031424) |
| 0.5 | 7.7 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 0.3 | 7.5 | GO:0030214 | hyaluronan catabolic process(GO:0030214) |
| 0.1 | 7.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 1.1 | 6.6 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.7 | 6.0 | GO:0038044 | transforming growth factor-beta secretion(GO:0038044) |
| 0.0 | 5.8 | GO:0017148 | negative regulation of translation(GO:0017148) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 32.9 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.0 | 22.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 17.6 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.2 | 13.0 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.2 | 10.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.8 | 6.8 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 1.5 | 6.0 | GO:0034685 | integrin alphav-beta6 complex(GO:0034685) |
| 0.4 | 5.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.2 | 4.9 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 0.0 | 4.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 40.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.8 | 29.4 | GO:0001972 | retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020) |
| 1.2 | 15.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 13.3 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 11.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 10.4 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 9.0 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 7.5 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.1 | 7.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.3 | 6.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 36.0 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 15.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 10.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 8.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 8.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 5.0 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 4.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.3 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.0 | 4.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 40.4 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.7 | 17.4 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.5 | 15.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.2 | 6.1 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.2 | 6.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.2 | 5.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.6 | 5.4 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.1 | 5.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 5.2 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.3 | 5.1 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |