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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NFIA
Z-value: 0.82
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Transcription factors associated with NFIA
Network of associatons between targets according to the STRING database.
First level regulatory network of NFIA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_14885845 Show fit | 11.20 |
ENST00000539261.6
ENST00000228938.5 |
matrix Gla protein |
|
| chr4_-_56681588 Show fit | 10.86 |
ENST00000554144.5
ENST00000381260.7 |
HOP homeobox |
|
| chr18_+_31591869 Show fit | 10.65 |
ENST00000237014.8
|
transthyretin |
|
| chr4_-_56681288 Show fit | 10.40 |
ENST00000556376.6
ENST00000420433.6 |
HOP homeobox |
|
| chr16_+_58249910 Show fit | 9.45 |
ENST00000219299.8
ENST00000443128.6 ENST00000616795.1 |
coiled-coil domain containing 113 |
|
| chr11_-_5254741 Show fit | 8.76 |
ENST00000444587.1
ENST00000336906.6 ENST00000642908.1 ENST00000647543.1 |
hemoglobin subunit gamma 2 novel protein |
|
| chr11_-_5249836 Show fit | 7.79 |
ENST00000632727.1
ENST00000330597.5 |
hemoglobin subunit gamma 1 |
|
| chr8_-_22232020 Show fit | 7.49 |
ENST00000454243.7
ENST00000321613.7 |
phytanoyl-CoA 2-hydroxylase interacting protein |
|
| chr17_-_10549694 Show fit | 7.25 |
ENST00000622564.4
|
myosin heavy chain 2 |
|
| chrX_+_103776831 Show fit | 7.15 |
ENST00000621218.5
ENST00000619236.1 |
proteolipid protein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 21.3 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 2.1 | 20.8 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.2 | 18.0 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 2.9 | 17.6 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.9 | 16.6 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.3 | 13.5 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 1.3 | 13.4 | GO:0021633 | optic nerve structural organization(GO:0021633) |
| 0.1 | 13.1 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.7 | 12.9 | GO:0060347 | heart trabecula formation(GO:0060347) |
| 0.2 | 12.9 | GO:0043268 | positive regulation of potassium ion transport(GO:0043268) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 33.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.4 | 21.1 | GO:0031430 | M band(GO:0031430) |
| 1.4 | 20.4 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 18.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 3.6 | 18.0 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 1.3 | 17.2 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 1.0 | 16.9 | GO:0033010 | paranodal junction(GO:0033010) |
| 0.5 | 13.3 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.4 | 12.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 12.8 | GO:0035580 | specific granule lumen(GO:0035580) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 22.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.5 | 21.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 18.8 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 2.2 | 17.6 | GO:0015235 | cobalamin transporter activity(GO:0015235) |
| 1.1 | 16.6 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.2 | 15.5 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.6 | 14.1 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 1.0 | 13.6 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 12.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 1.0 | 12.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 29.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 25.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 21.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 20.7 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.3 | 19.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.2 | 17.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 13.4 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.2 | 9.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.7 | 8.8 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 8.2 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.2 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.2 | 14.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 13.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.4 | 11.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 11.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.6 | 11.0 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.6 | 9.6 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 9.0 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.1 | 8.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 7.7 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |