ISMARA results: NFIL3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFIL3

Z-value: 1.55

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Transcription factors associated with NFIL3

Gene Symbol	Gene ID	Gene Info
NFIL3 Ensembl NCBI GeneCards UniProt	ENSG00000165030.4	NFIL3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIL3	hg38_v1_chr9_-_91423819_91423841	-0.07	3.3e-01	Click!

Activity profile of NFIL3 motif

Sorted Z-values of NFIL3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIL3

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr8_-_27611325 Show fit	53.60	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr12_-_91179517 Show fit	37.23	ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_91179355 Show fit	36.84	ENST00000550563.5 ENST00000546370.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_91179472 Show fit	34.97	ENST00000550099.5 ENST00000546391.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr13_-_44474296 Show fit	32.65	ENST00000611198.4	TSC22D1 Ensembl NCBI GeneCards UniProt Show fit	TSC22 domain family member 1
chr4_-_87529359 Show fit	31.36	ENST00000458304.2 ENST00000282470.11	SPARCL1 Ensembl NCBI GeneCards UniProt Show fit	SPARC like 1
chr4_-_87529460 Show fit	30.65	ENST00000418378.5	SPARCL1 Ensembl NCBI GeneCards UniProt Show fit	SPARC like 1
chr5_+_151025343 Show fit	27.91	ENST00000521632.1	GPX3 Ensembl NCBI GeneCards UniProt Show fit	glutathione peroxidase 3
chr11_-_5227063 Show fit	25.97	ENST00000335295.4 ENST00000485743.1 ENST00000647020.1	HBB Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit beta
chr9_+_136977496 Show fit	25.84	ENST00000371625.8 ENST00000457950.5	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.6	138.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
15.8	78.9	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.4	72.2	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7	60.8	GO:0045187	regulation of circadian sleep/wake cycle, sleep(GO:0045187)
0.5	49.0	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
14.5	43.6	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199) response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
5.2	31.3	GO:0009753	response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.0	29.9	GO:0035428	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
1.3	28.7	GO:0052695	cellular glucuronidation(GO:0052695)
9.3	27.9	GO:0006982	response to lipid hydroperoxide(GO:0006982)

Showing 1 to 10 of 401 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	149.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
9.9	128.2	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
5.3	84.9	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	59.7	GO:0060076	excitatory synapse(GO:0060076)
0.0	59.0	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.0	56.5	GO:0031224	intrinsic component of membrane(GO:0031224)
0.5	52.6	GO:0031091	platelet alpha granule(GO:0031091)
1.2	34.1	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.2	32.3	GO:0034705	voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
7.8	31.3	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)

Showing 1 to 10 of 174 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	228.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	106.9	GO:0003700	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
3.2	74.3	GO:0051787	misfolded protein binding(GO:0051787)
0.1	69.6	GO:0005509	calcium ion binding(GO:0005509)
0.1	47.5	GO:0003779	actin binding(GO:0003779)
2.4	45.2	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
1.2	44.4	GO:0015020	glucuronosyltransferase activity(GO:0015020)
5.2	36.2	GO:0030492	hemoglobin binding(GO:0030492)
2.3	32.6	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.3	30.1	GO:0004984	olfactory receptor activity(GO:0004984)

Showing 1 to 10 of 280 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	168.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
2.4	120.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.7	95.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.9	67.2	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.2	42.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	36.7	SIG PIP3 SIGNALING IN CARDIAC MYOCTES	Genes related to PIP3 signaling in cardiac myocytes
0.6	33.4	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.8	30.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.4	26.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.5	20.9	PID ATM PATHWAY	ATM pathway

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.7	128.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.7	111.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	76.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.1	51.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
1.6	40.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.4	40.2	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.4	27.5	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
2.5	24.6	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
1.4	24.4	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI
1.1	24.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle

Showing 1 to 10 of 95 entries

Results for NFIL3

Z-value: 1.55

Motif logo

Transcription factors associated with NFIL3

Activity-expression correlation:

Activity profile of NFIL3 motif

Sorted Z-values of NFIL3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIL3

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: