ISMARA results: NFIX

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFIX_NFIB

Z-value: 2.75

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Transcription factors associated with NFIX_NFIB

Gene Symbol	Gene ID	Gene Info
NFIX Ensembl NCBI GeneCards UniProt	ENSG00000008441.18	NFIX
NFIB Ensembl NCBI GeneCards UniProt	ENSG00000147862.17	NFIB

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFIB	hg38_v1_chr9_-_14307928_14308073	0.43	2.6e-11	Click!
NFIX	hg38_v1_chr19_+_13024917_13024972, hg38_v1_chr19_+_12995554_12995608, hg38_v1_chr19_+_13023958_13024032, hg38_v1_chr19_+_12995467_12995500	0.30	6.3e-06	Click!

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_9115907 Show fit	59.11	ENST00000318602.12	A2M Ensembl NCBI GeneCards UniProt Show fit	alpha-2-macroglobulin
chr16_+_176659 Show fit	57.18	ENST00000320868.9 ENST00000397797.1	HBA1 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 1
chr16_+_172869 Show fit	53.81	ENST00000251595.11 ENST00000397806.1 ENST00000484216.1	HBA2 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 2
chr3_+_45026296 Show fit	49.31	ENST00000296130.5	CLEC3B Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain family 3 member B
chr7_+_94394886 Show fit	48.03	ENST00000297268.11 ENST00000620463.1	COL1A2 Ensembl NCBI GeneCards UniProt Show fit	collagen type I alpha 2 chain
chr4_-_87529359 Show fit	47.79	ENST00000458304.2 ENST00000282470.11	SPARCL1 Ensembl NCBI GeneCards UniProt Show fit	SPARC like 1
chr4_-_87529460 Show fit	47.61	ENST00000418378.5	SPARCL1 Ensembl NCBI GeneCards UniProt Show fit	SPARC like 1
chr18_+_31591869 Show fit	42.50	ENST00000237014.8	TTR Ensembl NCBI GeneCards UniProt Show fit	transthyretin
chr4_-_87529092 Show fit	40.24	ENST00000503414.5	SPARCL1 Ensembl NCBI GeneCards UniProt Show fit	SPARC like 1
chr6_-_158999748 Show fit	40.15	ENST00000449822.5	RSPH3 Ensembl NCBI GeneCards UniProt Show fit	radial spoke head 3

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.4	122.3	GO:0015671	oxygen transport(GO:0015671)
0.8	104.4	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.0	101.9	GO:2001135	regulation of endocytic recycling(GO:2001135)
4.7	84.6	GO:0070208	protein heterotrimerization(GO:0070208)
2.0	81.6	GO:0018149	peptide cross-linking(GO:0018149)
4.6	74.0	GO:0032060	bleb assembly(GO:0032060)
24.5	73.5	GO:0001868	regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869)
6.1	72.8	GO:0051612	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
1.1	71.6	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
6.4	70.6	GO:0043152	induction of bacterial agglutination(GO:0043152)

Showing 1 to 10 of 954 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	615.2	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.5	575.5	GO:0005615	extracellular space(GO:0005615)
1.3	489.7	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	487.1	GO:0031224	intrinsic component of membrane(GO:0031224)
0.6	140.7	GO:0016323	basolateral plasma membrane(GO:0016323)
1.3	88.1	GO:0005796	Golgi lumen(GO:0005796)
1.9	87.8	GO:0001533	cornified envelope(GO:0001533)
1.1	85.2	GO:0031093	platelet alpha granule lumen(GO:0031093)
5.2	77.9	GO:0097418	neurofibrillary tangle(GO:0097418)
4.5	77.3	GO:0033010	paranodal junction(GO:0033010)

Showing 1 to 10 of 290 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	221.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
2.6	206.7	GO:0050840	extracellular matrix binding(GO:0050840)
1.3	166.2	GO:0008201	heparin binding(GO:0008201)
9.6	143.9	GO:0005344	oxygen transporter activity(GO:0005344)
1.4	138.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	127.6	GO:0005509	calcium ion binding(GO:0005509)
0.6	99.1	GO:0017137	Rab GTPase binding(GO:0017137)
0.6	87.5	GO:0005516	calmodulin binding(GO:0005516)
1.7	81.7	GO:0008009	chemokine activity(GO:0008009)
1.0	76.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)

Showing 1 to 10 of 632 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	578.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
1.5	408.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.7	301.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.6	181.3	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.5	153.5	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
1.8	113.2	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
1.4	94.6	PID FGF PATHWAY	FGF signaling pathway
2.2	92.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
1.7	72.2	ST GA12 PATHWAY	G alpha 12 Pathway
1.2	56.8	ST ADRENERGIC	Adrenergic Pathway

Showing 1 to 10 of 104 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	227.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
2.7	129.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.3	97.4	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
5.7	96.7	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
1.2	86.5	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.9	85.4	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
3.8	84.1	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.3	81.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
4.5	81.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.1	81.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 162 entries

Results for NFIX_NFIB

Z-value: 2.75

Motif logo

Transcription factors associated with NFIX_NFIB

Activity-expression correlation:

Activity profile of NFIX_NFIB motif

Sorted Z-values of NFIX_NFIB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFIX_NFIB

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: