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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFKB1

Z-value: 1.37

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Transcription factors associated with NFKB1

Gene Symbol Gene ID Gene Info
ENSG00000109320.13 NFKB1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFKB1hg38_v1_chr4_+_102501885_102501957,
hg38_v1_chr4_+_102501298_102501474
0.337.1e-07Click!

Activity profile of NFKB1 motif

Sorted Z-values of NFKB1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NFKB1

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr5_-_150412743 52.08 ENST00000353334.11
ENST00000009530.12
ENST00000377795.7
CD74 molecule
chr6_+_32637419 31.44 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr17_+_42288464 30.28 ENST00000590726.7
ENST00000678903.1
ENST00000590949.6
ENST00000676585.1
ENST00000588868.5
signal transducer and activator of transcription 5A
chr19_+_1067144 29.26 ENST00000313093.7
Rho GTPase activating protein 45
chr19_+_1067493 28.41 ENST00000586866.5
Rho GTPase activating protein 45
chr19_+_1067272 28.35 ENST00000590214.5
Rho GTPase activating protein 45
chr6_+_137867241 27.58 ENST00000612899.5
ENST00000420009.5
TNF alpha induced protein 3
chr22_-_37244237 27.01 ENST00000401529.3
ENST00000249071.11
Rac family small GTPase 2
chr6_+_137867414 26.27 ENST00000237289.8
ENST00000433680.1
TNF alpha induced protein 3
chr17_+_42288429 25.29 ENST00000676631.1
ENST00000677893.1
signal transducer and activator of transcription 5A
chr6_+_14117764 23.70 ENST00000379153.4
CD83 molecule
chr6_-_31582415 22.98 ENST00000429299.3
ENST00000446745.2
lymphotoxin beta
chr6_+_32637396 22.19 ENST00000395363.5
ENST00000496318.5
ENST00000343139.11
major histocompatibility complex, class II, DQ alpha 1
chr16_+_50742110 20.72 ENST00000566679.6
ENST00000564634.5
ENST00000398568.6
CYLD lysine 63 deubiquitinase
chr16_+_50742037 20.70 ENST00000569418.5
CYLD lysine 63 deubiquitinase
chr11_-_73142308 19.65 ENST00000409418.9
FCH and double SH3 domains 2
chr15_+_85380625 19.38 ENST00000560302.5
A-kinase anchoring protein 13
chr22_-_37244417 19.21 ENST00000405484.5
ENST00000441619.5
ENST00000406508.5
Rac family small GTPase 2
chr15_+_85380672 17.10 ENST00000361243.6
ENST00000560256.1
A-kinase anchoring protein 13
chr11_-_58578096 17.04 ENST00000528954.5
ENST00000528489.1
leupaxin
chr19_+_50418930 17.04 ENST00000439922.6
ENST00000595883.6
ENST00000597855.5
ENST00000596074.5
ENST00000594685.1
ENST00000270632.7
Spi-B transcription factor
chr16_+_50742059 16.58 ENST00000311559.13
ENST00000564326.5
ENST00000566206.5
ENST00000427738.8
CYLD lysine 63 deubiquitinase
chr19_+_41877267 16.10 ENST00000221972.8
ENST00000597454.1
ENST00000444740.2
CD79a molecule
chr12_-_9760893 15.97 ENST00000228434.7
ENST00000536709.1
CD69 molecule
chr11_+_114059702 15.30 ENST00000335953.9
ENST00000684612.1
ENST00000682810.1
ENST00000544220.1
zinc finger and BTB domain containing 16
chr11_+_114059755 15.23 ENST00000684295.1
zinc finger and BTB domain containing 16
chr3_-_18425295 14.21 ENST00000338745.11
ENST00000450898.1
SATB homeobox 1
chr6_+_29723340 13.37 ENST00000334668.8
major histocompatibility complex, class I, F
chr6_+_29723421 13.29 ENST00000259951.12
ENST00000434407.6
major histocompatibility complex, class I, F
chr10_+_102394488 13.04 ENST00000369966.8
nuclear factor kappa B subunit 2
chr2_-_43226594 13.00 ENST00000282388.4
ZFP36 ring finger protein like 2
chr11_+_114060204 12.92 ENST00000683318.1
zinc finger and BTB domain containing 16
chr6_+_32854179 12.83 ENST00000374859.3
proteasome 20S subunit beta 9
chr3_+_101827982 12.82 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKB inhibitor zeta
chr1_-_202159977 12.63 ENST00000367279.8
protein tyrosine phosphatase non-receptor type 7
chr14_-_35404650 12.61 ENST00000553342.1
ENST00000557140.5
ENST00000216797.10
NFKB inhibitor alpha
chr22_-_38755990 12.26 ENST00000405018.5
ENST00000438058.5
Sad1 and UNC84 domain containing 2
chr15_+_85380565 12.23 ENST00000559362.5
ENST00000394518.7
A-kinase anchoring protein 13
chr17_-_63699730 12.16 ENST00000578061.5
LIM domain containing 2
chr14_+_75522531 11.78 ENST00000555504.1
basic leucine zipper ATF-like transcription factor
chr2_+_60881553 11.25 ENST00000394479.4
REL proto-oncogene, NF-kB subunit
chr14_-_64503775 11.23 ENST00000608382.6
zinc finger and BTB domain containing 25
chr6_+_292050 11.08 ENST00000344450.9
dual specificity phosphatase 22
chr5_-_178627001 10.81 ENST00000611575.4
ENST00000520957.1
ENST00000316308.9
ENST00000611733.4
CDC like kinase 4
chr19_-_38899800 10.76 ENST00000414941.5
ENST00000358931.9
ENST00000392081.6
sirtuin 2
chr19_+_17527250 10.52 ENST00000599164.6
ENST00000449408.6
ENST00000600871.5
ENST00000599124.1
niban apoptosis regulator 3
chr1_+_6785437 10.44 ENST00000303635.12
ENST00000473578.5
ENST00000557126.5
calmodulin binding transcription activator 1
chr22_-_38755458 10.15 ENST00000405510.5
ENST00000433561.5
Sad1 and UNC84 domain containing 2
chr12_+_52051402 10.09 ENST00000243050.5
ENST00000550763.1
ENST00000394825.6
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
nuclear receptor subfamily 4 group A member 1
chr2_+_60881515 10.01 ENST00000295025.12
REL proto-oncogene, NF-kB subunit
chr10_-_73808616 9.87 ENST00000299641.8
N-deacetylase and N-sulfotransferase 2
chr1_-_202161575 9.42 ENST00000309017.7
ENST00000477554.5
ENST00000492451.1
protein tyrosine phosphatase non-receptor type 7
chr19_+_2476118 9.00 ENST00000215631.9
ENST00000587345.1
growth arrest and DNA damage inducible beta
chr11_+_118883884 8.98 ENST00000292174.5
C-X-C motif chemokine receptor 5
chr6_+_135181323 8.92 ENST00000367814.8
MYB proto-oncogene, transcription factor
chr19_+_45001430 8.66 ENST00000625761.2
ENST00000505236.1
ENST00000221452.13
RELB proto-oncogene, NF-kB subunit
chr2_-_100104530 8.59 ENST00000432037.5
ENST00000673232.1
ENST00000423966.6
ENST00000409236.6
AF4/FMR2 family member 3
chr19_-_38899529 8.49 ENST00000249396.12
ENST00000437828.5
sirtuin 2
chr19_-_36152427 8.39 ENST00000589154.1
ENST00000292907.8
cytochrome c oxidase subunit 7A1
chr17_-_1516601 8.34 ENST00000421807.7
ENST00000477910.5
ENST00000575172.5
inositol polyphosphate-5-phosphatase K
chr11_+_102317542 8.34 ENST00000532808.5
baculoviral IAP repeat containing 3
chr17_-_1516699 8.19 ENST00000320345.10
ENST00000406424.8
inositol polyphosphate-5-phosphatase K
chr18_+_13218195 8.16 ENST00000679167.1
low density lipoprotein receptor class A domain containing 4
chr3_+_53161241 8.00 ENST00000477794.2
ENST00000650739.1
protein kinase C delta
chr6_+_106086316 7.97 ENST00000369091.6
ENST00000369096.9
PR/SET domain 1
chr1_+_156153568 7.87 ENST00000368284.5
ENST00000368286.6
ENST00000368285.8
ENST00000438830.5
semaphorin 4A
chr1_+_111227610 7.81 ENST00000369744.6
chitinase 3 like 2
chr1_+_111227699 7.72 ENST00000369748.9
chitinase 3 like 2
chr1_-_235866867 7.65 ENST00000389793.7
lysosomal trafficking regulator
chr11_-_73142032 7.59 ENST00000311172.11
ENST00000409314.5
FCH and double SH3 domains 2
chr19_+_40717091 7.50 ENST00000263370.3
inositol-trisphosphate 3-kinase C
chr2_+_96536743 7.45 ENST00000673792.1
ENST00000357485.8
AT-rich interaction domain 5A
chr19_+_41860236 7.43 ENST00000601492.5
ENST00000600467.6
ENST00000598742.6
ENST00000221975.6
ENST00000598261.2
ribosomal protein S19
chr6_+_144150492 7.32 ENST00000367568.5
syntaxin 11
chr3_-_50567646 7.30 ENST00000426034.5
ENST00000441239.5
chromosome 3 open reading frame 18
chr12_-_54588636 7.29 ENST00000257905.13
protein phosphatase 1 regulatory inhibitor subunit 1A
chr2_-_152098810 7.24 ENST00000636442.1
ENST00000638005.1
calcium voltage-gated channel auxiliary subunit beta 4
chr4_+_102501298 7.03 ENST00000394820.8
ENST00000226574.9
ENST00000511926.5
ENST00000507079.5
nuclear factor kappa B subunit 1
chr2_-_152099023 6.75 ENST00000201943.10
ENST00000427385.6
ENST00000539935.7
calcium voltage-gated channel auxiliary subunit beta 4
chr17_-_1516621 6.70 ENST00000574561.1
inositol polyphosphate-5-phosphatase K
chr9_+_79572572 6.70 ENST00000435650.5
ENST00000414465.5
ENST00000376537.8
TLE family member 4, transcriptional corepressor
chr6_+_135181268 6.69 ENST00000341911.10
ENST00000442647.7
ENST00000618728.4
ENST00000316528.12
ENST00000616088.4
MYB proto-oncogene, transcription factor
chr11_+_102317450 6.67 ENST00000615299.4
ENST00000527309.2
ENST00000526421.6
ENST00000263464.9
baculoviral IAP repeat containing 3
chr9_+_79572715 6.67 ENST00000265284.10
TLE family member 4, transcriptional corepressor
chr1_-_161309961 6.61 ENST00000533357.5
ENST00000672602.2
ENST00000526189.3
myelin protein zero
chr11_-_64803152 6.61 ENST00000439069.5
ENST00000294066.7
ENST00000377350.7
mitogen-activated protein kinase kinase kinase kinase 2
chr2_+_96537254 6.49 ENST00000454558.2
AT-rich interaction domain 5A
chr10_+_30434021 6.43 ENST00000542547.5
mitogen-activated protein kinase kinase kinase 8
chr6_-_32853813 6.41 ENST00000643049.2
transporter 1, ATP binding cassette subfamily B member
chr18_+_13217676 6.35 ENST00000679177.1
low density lipoprotein receptor class A domain containing 4
chr17_-_7294592 6.33 ENST00000007699.10
Y-box binding protein 2
chr6_-_32853618 6.33 ENST00000354258.5
transporter 1, ATP binding cassette subfamily B member
chr3_-_50567711 6.32 ENST00000357203.8
chromosome 3 open reading frame 18
chr16_+_28824116 6.25 ENST00000568266.5
ataxin 2 like
chr17_+_42289213 6.25 ENST00000677301.1
signal transducer and activator of transcription 5A
chr4_-_119628791 6.19 ENST00000354960.8
phosphodiesterase 5A
chr14_+_102777555 6.19 ENST00000539721.5
ENST00000560463.5
TNF receptor associated factor 3
chr8_-_132481057 6.12 ENST00000388996.10
potassium voltage-gated channel subfamily Q member 3
chr12_+_100267162 6.11 ENST00000548392.5
ENST00000360820.7
SCY1 like pseudokinase 2
chr1_+_37474572 6.06 ENST00000373087.7
zinc finger CCCH-type containing 12A
chr17_-_7219813 6.02 ENST00000399510.8
ENST00000648172.8
discs large MAGUK scaffold protein 4
chr4_-_76007501 5.99 ENST00000264888.6
C-X-C motif chemokine ligand 9
chr1_+_100352451 5.97 ENST00000361544.11
ENST00000370124.8
ENST00000336454.5
cell division cycle 14A
chr12_+_100267220 5.87 ENST00000635101.1
SCY1 like pseudokinase 2
chr2_-_152098670 5.84 ENST00000636129.1
ENST00000636785.1
ENST00000636496.1
calcium voltage-gated channel auxiliary subunit beta 4
chr1_-_57424014 5.83 ENST00000371230.1
ENST00000371236.7
DAB adaptor protein 1
chr20_+_46118277 5.78 ENST00000620709.4
CD40 molecule
chr9_-_133479075 5.74 ENST00000414172.1
ENST00000371897.8
ENST00000371899.9
solute carrier family 2 member 6
chr1_+_211259279 5.72 ENST00000367006.8
ENST00000419091.7
ENST00000452621.6
REST corepressor 3
chr3_+_53161120 5.66 ENST00000394729.6
ENST00000330452.8
ENST00000652449.1
protein kinase C delta
chr14_+_76151898 5.62 ENST00000557542.5
ENST00000556109.1
ENST00000557263.5
ENST00000261530.12
ENST00000312858.9
G-patch domain containing 2 like
chr21_+_25639251 5.61 ENST00000480456.6
junctional adhesion molecule 2
chr7_+_143316105 5.56 ENST00000343257.7
ENST00000650516.1
chloride voltage-gated channel 1
chr1_+_183472483 5.49 ENST00000507691.6
ENST00000508461.5
ENST00000419169.5
ENST00000347615.6
ENST00000507469.5
ENST00000515829.6
ENST00000638826.1
SMG7 nonsense mediated mRNA decay factor
chr6_-_29559724 5.49 ENST00000377050.5
ubiquitin D
chr1_-_235866916 5.43 ENST00000389794.7
lysosomal trafficking regulator
chr5_-_151141631 5.43 ENST00000523714.5
ENST00000521749.5
annexin A6
chr5_-_96807899 5.37 ENST00000503921.5
ENST00000508227.5
ENST00000507154.1
ENST00000443439.7
endoplasmic reticulum aminopeptidase 1
chr14_+_64503943 5.35 ENST00000556965.1
ENST00000554015.5
zinc finger and BTB domain containing 1
chr10_+_30434176 5.33 ENST00000263056.6
ENST00000375322.2
mitogen-activated protein kinase kinase kinase 8
chr11_-_3840942 5.32 ENST00000351018.5
ras homolog family member G
chr19_-_17847962 5.31 ENST00000458235.7
ENST00000534444.1
Janus kinase 3
chr9_+_79573162 5.28 ENST00000425506.5
TLE family member 4, transcriptional corepressor
chr17_-_1628808 5.27 ENST00000301335.10
solute carrier family 43 member 2
chr1_+_27234612 5.19 ENST00000319394.8
ENST00000361771.7
WD and tetratricopeptide repeats 1
chr6_+_147508645 5.13 ENST00000367474.2
sterile alpha motif domain containing 5
chr11_-_47378527 5.07 ENST00000378538.8
Spi-1 proto-oncogene
chr15_-_70763539 5.06 ENST00000322954.11
uveal autoantigen with coiled-coil domains and ankyrin repeats
chr9_+_19230680 5.00 ENST00000434457.7
DENN domain containing 4C
chr17_-_42181116 4.97 ENST00000264661.4
potassium voltage-gated channel subfamily H member 4
chr11_+_102317492 4.96 ENST00000673846.1
baculoviral IAP repeat containing 3
chr11_-_47378391 4.96 ENST00000227163.8
Spi-1 proto-oncogene
chr5_+_140401860 4.94 ENST00000532219.5
ENST00000394722.7
ANKHD1-EIF4EBP3 readthrough
ankyrin repeat and KH domain containing 1
chr1_-_161199044 4.94 ENST00000367995.3
ENST00000367996.6
ADAM metallopeptidase with thrombospondin type 1 motif 4
chr11_+_1839452 4.90 ENST00000381906.5
troponin I2, fast skeletal type
chr17_+_4731410 4.84 ENST00000575284.5
ENST00000293777.6
ENST00000674339.1
ENST00000573708.1
mediator complex subunit 11
chr4_-_76023489 4.83 ENST00000306602.3
C-X-C motif chemokine ligand 10
chr17_+_7834200 4.82 ENST00000448097.7
lysine demethylase 6B
chr12_-_57110284 4.78 ENST00000543873.6
ENST00000554663.5
ENST00000557635.5
signal transducer and activator of transcription 6
chr17_-_42181081 4.77 ENST00000607371.5
potassium voltage-gated channel subfamily H member 4
chr6_-_33200614 4.73 ENST00000374685.8
ENST00000374680.4
retinoid X receptor beta
chr6_+_33410961 4.70 ENST00000374512.7
ENST00000374516.8
PHD finger protein 1
chr16_+_28823212 4.69 ENST00000570200.5
ataxin 2 like
chr17_+_50561010 4.67 ENST00000360761.8
ENST00000354983.8
ENST00000352832.9
calcium voltage-gated channel subunit alpha1 G
chr1_+_183472465 4.66 ENST00000367537.7
SMG7 nonsense mediated mRNA decay factor
chr12_+_63844663 4.66 ENST00000355086.8
SLIT-ROBO Rho GTPase activating protein 1
chr15_+_88803468 4.65 ENST00000558207.5
aggrecan
chrX_+_148500708 4.61 ENST00000342251.7
AF4/FMR2 family member 2
chr5_-_95961830 4.60 ENST00000513343.1
ENST00000237853.9
elongation factor for RNA polymerase II 2
chr20_+_46118300 4.57 ENST00000372285.8
ENST00000372276.7
CD40 molecule
chr3_-_194351290 4.56 ENST00000429275.1
ENST00000323830.4
carboxypeptidase N subunit 2
chr20_-_49915509 4.56 ENST00000289431.10
spermatogenesis associated 2
chr16_+_28822982 4.54 ENST00000336783.9
ENST00000340394.12
ENST00000325215.10
ENST00000382686.8
ENST00000395547.6
ENST00000564304.5
ataxin 2 like
chr11_+_47269641 4.52 ENST00000428807.5
ENST00000402799.5
ENST00000406482.5
ENST00000349238.7
ENST00000311027.9
ENST00000407859.7
ENST00000395344.7
ENST00000444117.5
MAP kinase activating death domain
chr2_-_206086057 4.52 ENST00000403263.6
INO80 complex subunit D
chr6_-_33192454 4.48 ENST00000395194.1
ENST00000341947.7
ENST00000374708.8
collagen type XI alpha 2 chain
chr7_-_101237827 4.41 ENST00000611078.4
claudin 15
chr2_-_152099155 4.41 ENST00000637309.1
calcium voltage-gated channel auxiliary subunit beta 4
chr19_+_51225059 4.41 ENST00000436584.6
ENST00000421133.6
ENST00000262262.5
ENST00000391796.7
CD33 molecule
chr17_-_7205116 4.36 ENST00000649520.1
ENST00000649186.1
discs large MAGUK scaffold protein 4
chr15_-_26773737 4.24 ENST00000299267.8
gamma-aminobutyric acid type A receptor subunit beta3
chr11_+_64230278 4.18 ENST00000628077.2
ENST00000321685.7
DnaJ heat shock protein family (Hsp40) member C4
chr19_-_2042066 4.18 ENST00000591588.1
ENST00000591142.5
MAPK interacting serine/threonine kinase 2
chr12_+_49972837 4.17 ENST00000618286.1
ENST00000315520.10
aquaporin 6
chr4_-_74038681 4.15 ENST00000296026.4
C-X-C motif chemokine ligand 3
chr5_+_68215738 4.12 ENST00000521381.6
ENST00000521657.5
phosphoinositide-3-kinase regulatory subunit 1
chr6_+_31982057 4.11 ENST00000428956.7
ENST00000498271.1
complement C4A (Rodgers blood group)
chr12_-_57129001 4.10 ENST00000556155.5
signal transducer and activator of transcription 6
chr14_+_75069577 4.09 ENST00000238686.8
zinc finger C2HC-type containing 1C
chr4_-_119628007 3.93 ENST00000420633.1
ENST00000394439.5
phosphodiesterase 5A
chr17_+_42567072 3.91 ENST00000246912.8
ENST00000346833.8
ENST00000591024.1
MAX dimerization protein MLX
chr4_-_74099187 3.89 ENST00000508487.3
C-X-C motif chemokine ligand 2
chr15_-_75451650 3.89 ENST00000567289.5
ENST00000394947.8
ENST00000565264.1
SIN3 transcription regulator family member A
chr12_-_11171593 3.85 ENST00000535024.6
PRH1-PRR4 readthrough
chr14_+_32329256 3.82 ENST00000280979.9
A-kinase anchoring protein 6
chr1_+_53894181 3.77 ENST00000361921.8
ENST00000322679.10
ENST00000613679.4
ENST00000617230.2
ENST00000610607.4
ENST00000532493.5
ENST00000525202.5
ENST00000524406.5
ENST00000388876.3
iodothyronine deiodinase 1
chr11_-_77474087 3.76 ENST00000356341.8
p21 (RAC1) activated kinase 1
chr10_+_48306639 3.74 ENST00000395611.7
ENST00000432379.5
ENST00000374189.5
mitogen-activated protein kinase 8
chr19_-_41353904 3.71 ENST00000221930.6
transforming growth factor beta 1
chr11_-_77474041 3.70 ENST00000278568.8
p21 (RAC1) activated kinase 1
chr7_-_101237791 3.68 ENST00000308344.10
claudin 15
chr10_+_48306698 3.65 ENST00000374179.8
mitogen-activated protein kinase 8
chr10_+_115093331 3.61 ENST00000609571.5
ENST00000355044.8
ENST00000526946.5
attractin like 1
chr5_-_135895834 3.61 ENST00000274520.2
interleukin 9
chr4_-_76036060 3.52 ENST00000306621.8
C-X-C motif chemokine ligand 11
chr7_+_17298642 3.50 ENST00000242057.9
aryl hydrocarbon receptor
chr14_+_75069632 3.44 ENST00000439583.2
ENST00000554763.2
ENST00000524913.3
ENST00000525046.2
ENST00000674086.1
ENST00000526130.2
ENST00000674094.1
ENST00000532198.2
zinc finger C2HC-type containing 1C
chr3_+_9649433 3.43 ENST00000353332.9
ENST00000420925.5
ENST00000296003.9
ENST00000351233.9
myotubularin related protein 14
chr19_-_4182527 3.41 ENST00000601571.1
ENST00000601488.5
ENST00000305232.10
ENST00000337491.7
sirtuin 6
chr14_+_32939243 3.37 ENST00000346562.6
ENST00000548645.5
ENST00000356141.8
ENST00000357798.9
neuronal PAS domain protein 3
chr4_-_5888400 3.37 ENST00000397890.6
collapsin response mediator protein 1
chr10_-_124092445 3.36 ENST00000346248.7
carbohydrate sulfotransferase 15
chr9_+_68356899 3.34 ENST00000396392.5
phosphoglucomutase 5
chr16_+_1309136 3.32 ENST00000325437.9
ubiquitin conjugating enzyme E2 I
chr12_-_54419259 3.29 ENST00000293379.9
integrin subunit alpha 5
chr1_-_186680411 3.26 ENST00000367468.10
prostaglandin-endoperoxide synthase 2
chr15_+_100602519 3.24 ENST00000332783.12
ENST00000558747.5
ENST00000343276.4
ankyrin repeat and SOCS box containing 7
chrX_-_21758021 3.23 ENST00000646008.1
small muscle protein X-linked
chr20_-_46308485 3.23 ENST00000537909.4
cadherin 22
chr15_+_88803426 3.23 ENST00000560601.4
ENST00000561243.7
ENST00000439576.7
aggrecan

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.3 58.0 GO:1990108 protein linear deubiquitination(GO:1990108)
18.0 53.9 GO:0072573 regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573)
17.4 52.1 GO:0035691 macrophage migration inhibitory factor signaling pathway(GO:0035691)
12.2 48.7 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
8.8 61.8 GO:0000255 allantoin metabolic process(GO:0000255)
7.7 23.2 GO:2001153 regulation of renal water transport(GO:2001151) positive regulation of renal water transport(GO:2001153)
7.2 43.5 GO:0051138 positive regulation of NK T cell differentiation(GO:0051138)
6.4 19.3 GO:1900226 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
5.2 15.6 GO:1904899 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
4.6 13.7 GO:2000753 regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755)
4.5 22.4 GO:0031022 nuclear migration along microfilament(GO:0031022)
4.4 13.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
4.2 12.7 GO:0046967 cytosol to ER transport(GO:0046967)
4.2 46.2 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
3.4 13.6 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
3.4 10.1 GO:0060282 positive regulation of oocyte development(GO:0060282)
3.3 23.0 GO:0045084 positive regulation of interleukin-12 biosynthetic process(GO:0045084)
3.2 12.6 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
2.9 28.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
2.7 8.0 GO:1990654 regulation of extrathymic T cell differentiation(GO:0033082) sebum secreting cell proliferation(GO:1990654)
2.7 13.3 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.6 23.7 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
2.6 13.1 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
2.6 10.4 GO:0033590 response to cobalamin(GO:0033590)
2.5 7.4 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
2.5 7.4 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
2.2 8.9 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
2.1 17.0 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
2.1 6.3 GO:0009386 translational attenuation(GO:0009386)
1.9 5.8 GO:0097477 spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477)
1.9 13.0 GO:1904628 response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628)
1.8 5.3 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
1.7 20.0 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
1.7 29.9 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.4 7.2 GO:0002730 regulation of dendritic cell cytokine production(GO:0002730)
1.4 15.5 GO:0006032 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.4 4.1 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
1.3 12.0 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
1.3 14.3 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
1.3 7.8 GO:0035063 nuclear speck organization(GO:0035063)
1.3 3.9 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
1.2 9.7 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.2 4.7 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
1.2 8.1 GO:0002483 antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
1.1 3.4 GO:0031938 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) regulation of chromatin silencing at telomere(GO:0031938)
1.1 3.4 GO:1904616 regulation of actin filament binding(GO:1904529) regulation of actin binding(GO:1904616)
1.1 10.1 GO:0071376 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.1 4.5 GO:0060023 soft palate development(GO:0060023)
1.1 14.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.1 7.5 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
1.1 6.3 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
1.0 2.9 GO:1990451 cellular stress response to acidic pH(GO:1990451)
1.0 15.5 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
1.0 14.5 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.9 3.7 GO:0052031 tolerance induction to self antigen(GO:0002513) ossification involved in bone remodeling(GO:0043932) induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) positive regulation of mononuclear cell migration(GO:0071677) modulation by virus of host immune response(GO:0075528) negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.9 9.9 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.9 2.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.9 10.4 GO:0097113 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.8 3.3 GO:1903755 regulation of SUMO transferase activity(GO:1903182) positive regulation of SUMO transferase activity(GO:1903755)
0.8 2.5 GO:2000697 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
0.8 3.3 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8 12.9 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.8 3.0 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.8 4.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.8 2.3 GO:0071206 establishment of protein localization to juxtaparanode region of axon(GO:0071206)
0.7 11.1 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.7 2.1 GO:0033499 galactose catabolic process via UDP-galactose(GO:0033499)
0.7 4.8 GO:0071557 histone H3-K27 demethylation(GO:0071557)
0.7 5.5 GO:0070842 aggresome assembly(GO:0070842)
0.7 2.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 2.0 GO:0051040 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) regulation of calcium-independent cell-cell adhesion(GO:0051040) corticotropin hormone secreting cell differentiation(GO:0060128)
0.6 3.0 GO:0021590 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
0.6 3.6 GO:0000189 MAPK import into nucleus(GO:0000189)
0.6 14.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 27.2 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.5 2.7 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.5 4.0 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.5 7.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.5 1.9 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.5 4.7 GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371)
0.5 4.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.5 3.2 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.4 59.2 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.4 6.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.4 7.3 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane(GO:0031629) vesicle fusion to plasma membrane(GO:0099500)
0.4 2.6 GO:0048840 otolith development(GO:0048840)
0.4 3.3 GO:0019388 galactose catabolic process(GO:0019388)
0.4 7.9 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.4 24.3 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.4 2.3 GO:0006477 protein sulfation(GO:0006477)
0.4 4.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.4 7.7 GO:0045717 negative regulation of fatty acid biosynthetic process(GO:0045717)
0.4 2.6 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.4 1.5 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.4 0.7 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.3 5.0 GO:0048535 lymph node development(GO:0048535)
0.3 5.3 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.3 1.6 GO:0030070 insulin processing(GO:0030070)
0.3 1.6 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.3 1.9 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.3 1.6 GO:0033058 directional locomotion(GO:0033058)
0.3 2.7 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.3 0.8 GO:0099403 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) protein auto-ADP-ribosylation(GO:0070213) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of telomeric DNA binding(GO:1904742) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.3 5.6 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.3 4.2 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.3 3.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.3 4.1 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.3 2.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 1.8 GO:0072553 terminal button organization(GO:0072553)
0.3 1.8 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3 2.1 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 1.8 GO:0060267 positive regulation of respiratory burst(GO:0060267)
0.2 2.4 GO:0051601 exocyst localization(GO:0051601)
0.2 10.8 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.2 3.3 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.2 14.9 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.2 6.6 GO:0098743 cell aggregation(GO:0098743)
0.2 13.9 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.2 1.0 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.2 5.4 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.2 11.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 1.8 GO:0006600 creatine metabolic process(GO:0006600)
0.2 5.7 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.2 5.5 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 10.4 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.2 2.3 GO:0016322 neuron remodeling(GO:0016322)
0.2 4.2 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.2 4.2 GO:0006833 water transport(GO:0006833)
0.2 83.7 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.2 3.8 GO:0006590 thyroid hormone generation(GO:0006590)
0.2 12.7 GO:0035690 cellular response to drug(GO:0035690)
0.2 7.9 GO:0003009 skeletal muscle contraction(GO:0003009)
0.2 17.4 GO:0050853 B cell receptor signaling pathway(GO:0050853)
0.2 1.0 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.2 4.2 GO:0071420 cellular response to histamine(GO:0071420)
0.2 0.9 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.2 3.6 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.1 2.3 GO:0060285 cilium-dependent cell motility(GO:0060285)
0.1 5.3 GO:1902475 L-alpha-amino acid transmembrane transport(GO:1902475)
0.1 2.2 GO:0021794 thalamus development(GO:0021794)
0.1 0.8 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 3.1 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.1 1.5 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 1.6 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.1 15.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.1 1.6 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 1.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.1 2.1 GO:0050718 positive regulation of interleukin-1 beta secretion(GO:0050718)
0.1 1.0 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 3.0 GO:0007520 myoblast fusion(GO:0007520)
0.1 1.0 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.1 GO:0048853 forebrain morphogenesis(GO:0048853)
0.1 3.4 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.1 4.6 GO:1901222 regulation of NIK/NF-kappaB signaling(GO:1901222)
0.1 8.4 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 7.5 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 4.7 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 16.3 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 2.8 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.1 5.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.1 0.5 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 10.2 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.1 0.2 GO:0051572 negative regulation of histone H3-K36 methylation(GO:0000415) negative regulation of histone H3-K4 methylation(GO:0051572)
0.1 11.8 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 5.5 GO:2000257 regulation of protein activation cascade(GO:2000257)
0.0 1.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 3.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 4.3 GO:0006941 striated muscle contraction(GO:0006941)
0.0 2.0 GO:0002456 T cell mediated immunity(GO:0002456)
0.0 2.2 GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway(GO:0010803)
0.0 5.2 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 1.1 GO:0009948 anterior/posterior axis specification(GO:0009948)
0.0 0.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.0 1.7 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 3.0 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.1 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.0 1.2 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 1.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 4.3 GO:0007162 negative regulation of cell adhesion(GO:0007162)
0.0 4.5 GO:0006310 DNA recombination(GO:0006310)
0.0 1.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.5 GO:0030212 hyaluronan metabolic process(GO:0030212)
0.0 0.7 GO:0090003 regulation of establishment of protein localization to plasma membrane(GO:0090003)
0.0 0.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 2.5 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 1.2 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 105.7 GO:0042613 MHC class II protein complex(GO:0042613)
4.9 63.2 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
3.2 16.1 GO:0019815 B cell receptor complex(GO:0019815)
2.6 28.6 GO:0042611 MHC protein complex(GO:0042611)
2.5 12.7 GO:0042825 TAP complex(GO:0042825)
2.1 19.3 GO:0072687 meiotic spindle(GO:0072687)
1.8 12.8 GO:1990111 spermatoproteasome complex(GO:1990111)
1.7 22.4 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
1.5 4.5 GO:0005592 collagen type XI trimer(GO:0005592)
1.5 10.4 GO:0043196 varicosity(GO:0043196)
1.2 58.0 GO:0097542 ciliary tip(GO:0097542)
1.1 3.4 GO:0031933 telomeric heterochromatin(GO:0031933)
1.1 3.3 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
1.0 4.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.9 5.6 GO:0031501 mannosyltransferase complex(GO:0031501)
0.9 5.5 GO:0005927 muscle tendon junction(GO:0005927)
0.9 7.0 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.9 5.3 GO:0060091 kinocilium(GO:0060091)
0.9 6.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.8 3.3 GO:1990356 sumoylated E2 ligase complex(GO:1990356)
0.8 4.0 GO:0045160 myosin I complex(GO:0045160)
0.7 10.4 GO:0098839 postsynaptic density membrane(GO:0098839)
0.7 2.9 GO:1990393 3M complex(GO:1990393)
0.7 123.4 GO:0032587 ruffle membrane(GO:0032587)
0.7 49.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.7 2.7 GO:0070876 SOSS complex(GO:0070876)
0.6 3.5 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.5 47.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.5 5.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.5 5.0 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 2.7 GO:0001940 male pronucleus(GO:0001940)
0.4 17.1 GO:0002102 podosome(GO:0002102)
0.4 28.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 3.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 14.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.4 1.9 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.4 7.9 GO:0005861 troponin complex(GO:0005861)
0.4 2.2 GO:0005879 axonemal microtubule(GO:0005879)
0.4 4.7 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.3 2.8 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.3 7.5 GO:0043194 axon initial segment(GO:0043194)
0.3 37.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.3 27.2 GO:0031594 neuromuscular junction(GO:0031594)
0.3 1.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.3 1.6 GO:0071797 LUBAC complex(GO:0071797)
0.3 3.0 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.3 2.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 2.8 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.2 2.3 GO:0005858 axonemal dynein complex(GO:0005858)
0.2 1.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 15.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 2.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 26.2 GO:0016363 nuclear matrix(GO:0016363)
0.2 2.3 GO:0033268 node of Ranvier(GO:0033268)
0.2 1.4 GO:0061700 GATOR2 complex(GO:0061700)
0.2 56.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 2.4 GO:0000145 exocyst(GO:0000145)
0.2 4.2 GO:0030673 axolemma(GO:0030673)
0.1 1.3 GO:0044327 dendritic spine head(GO:0044327)
0.1 19.6 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 7.3 GO:0031201 SNARE complex(GO:0031201)
0.1 4.8 GO:0016592 mediator complex(GO:0016592)
0.1 5.5 GO:0016235 aggresome(GO:0016235)
0.1 3.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 2.9 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.1 9.8 GO:0034707 chloride channel complex(GO:0034707)
0.1 14.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 7.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 16.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.7 GO:0005901 caveola(GO:0005901)
0.1 1.0 GO:0042587 glycogen granule(GO:0042587)
0.1 8.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 10.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 1.0 GO:0043218 compact myelin(GO:0043218)
0.1 6.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 7.5 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.4 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 16.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 8.4 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 1.9 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.8 GO:0097431 mitotic spindle pole(GO:0097431)
0.1 2.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 34.7 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 8.3 GO:0001650 fibrillar center(GO:0001650)
0.1 1.2 GO:0005921 gap junction(GO:0005921)
0.0 12.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 4.2 GO:0016605 PML body(GO:0016605)
0.0 5.8 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.6 GO:0030133 transport vesicle(GO:0030133)
0.0 6.5 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 2.2 GO:0016323 basolateral plasma membrane(GO:0016323)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 111.9 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
7.4 52.1 GO:0042289 MHC class II protein binding(GO:0042289)
6.6 39.4 GO:0046979 TAP2 binding(GO:0046979)
6.4 19.3 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
4.5 53.6 GO:0032395 MHC class II receptor activity(GO:0032395)
3.9 46.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
3.7 51.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
2.9 23.2 GO:0005000 vasopressin receptor activity(GO:0005000)
2.9 14.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
2.5 9.9 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
2.3 13.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
2.0 8.1 GO:0005151 interleukin-1, Type II receptor binding(GO:0005151)
1.9 5.6 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
1.8 7.4 GO:0035033 histone deacetylase regulator activity(GO:0035033)
1.6 4.7 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.4 15.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.4 15.5 GO:0004568 chitinase activity(GO:0004568) chitin binding(GO:0008061)
1.4 9.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.4 28.7 GO:0043495 protein anchor(GO:0043495)
1.3 10.4 GO:0031812 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
1.2 13.3 GO:0051525 NFAT protein binding(GO:0051525)
1.2 4.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
1.2 3.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
1.1 4.4 GO:0004906 interferon-gamma receptor activity(GO:0004906)
1.1 7.5 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.0 19.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.0 3.0 GO:0030343 vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643)
1.0 2.9 GO:0035375 zymogen binding(GO:0035375)
1.0 2.9 GO:0030171 voltage-gated proton channel activity(GO:0030171)
0.9 7.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.9 45.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.9 2.6 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.8 3.4 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.8 3.3 GO:0061656 SUMO conjugating enzyme activity(GO:0061656)
0.8 3.3 GO:0050473 arachidonate 15-lipoxygenase activity(GO:0050473)
0.8 2.4 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.8 24.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.8 3.8 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.7 9.0 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.7 3.7 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.7 2.2 GO:0031862 prostanoid receptor binding(GO:0031862)
0.7 1.4 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.7 4.8 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
0.7 2.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.7 3.4 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.6 4.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.6 1.9 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.6 2.5 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.6 7.9 GO:0031014 troponin T binding(GO:0031014)
0.6 7.8 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.6 3.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 1.6 GO:0015275 stretch-activated, cation-selective, calcium channel activity(GO:0015275)
0.5 1.6 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 24.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.5 6.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.5 4.1 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.5 12.8 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.4 13.9 GO:0046965 retinoid X receptor binding(GO:0046965)
0.4 3.0 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.4 5.7 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.4 12.6 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 3.1 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.3 2.8 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.3 11.8 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 4.2 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.3 10.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.3 4.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.3 2.1 GO:0008172 S-methyltransferase activity(GO:0008172)
0.3 5.6 GO:0038191 neuropilin binding(GO:0038191)
0.3 8.4 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 4.0 GO:0017160 Ral GTPase binding(GO:0017160)
0.3 1.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.3 8.9 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 1.1 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.3 12.3 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 5.8 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.3 5.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 4.2 GO:0015250 water channel activity(GO:0015250)
0.3 100.3 GO:0005096 GTPase activator activity(GO:0005096)
0.3 1.0 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
0.2 14.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 3.0 GO:0004065 arylsulfatase activity(GO:0004065)
0.2 4.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.2 1.8 GO:0004111 creatine kinase activity(GO:0004111)
0.2 16.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.2 3.2 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 2.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 6.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.2 1.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 7.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 7.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 3.4 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.2 3.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.2 3.3 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.2 14.3 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 1.7 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.2 7.3 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 1.9 GO:0050700 CARD domain binding(GO:0050700)
0.2 3.0 GO:0019706 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 2.0 GO:0070700 BMP receptor binding(GO:0070700)
0.2 1.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.2 8.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 4.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 2.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 1.5 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 4.5 GO:0005123 death receptor binding(GO:0005123)
0.1 6.1 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 3.4 GO:0031005 filamin binding(GO:0031005)
0.1 10.1 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 2.1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 14.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.1 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 5.4 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.3 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.1 32.3 GO:0019887 protein kinase regulator activity(GO:0019887)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 8.9 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.1 15.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 5.3 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.1 5.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.9 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 3.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 4.7 GO:0035064 methylated histone binding(GO:0035064)
0.1 89.7 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 1.6 GO:0030552 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) cAMP binding(GO:0030552)
0.1 2.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.8 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 0.3 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 2.3 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.0 2.4 GO:0000149 SNARE binding(GO:0000149)
0.0 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.3 GO:0043621 protein self-association(GO:0043621)
0.0 1.0 GO:0005109 frizzled binding(GO:0005109)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 5.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 1.0 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 5.7 GO:0019901 protein kinase binding(GO:0019901)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 180.0 PID CD40 PATHWAY CD40/CD40L signaling
1.7 37.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
1.3 65.1 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
1.1 70.5 PID TNF PATHWAY TNF receptor signaling pathway
1.0 25.9 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.9 38.9 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.8 7.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.7 16.6 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.6 1.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.5 45.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 2.8 PID IL27 PATHWAY IL27-mediated signaling events
0.4 9.0 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 20.0 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 16.1 PID BCR 5PATHWAY BCR signaling pathway
0.3 22.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 10.4 ST GA12 PATHWAY G alpha 12 Pathway
0.3 10.5 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 4.2 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.2 5.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.2 10.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 2.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 7.2 PID REELIN PATHWAY Reelin signaling pathway
0.2 7.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 3.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 4.6 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 2.9 PID CONE PATHWAY Visual signal transduction: Cones
0.1 2.9 PID RAS PATHWAY Regulation of Ras family activation
0.1 7.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.1 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 4.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 5.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 13.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 26.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 5.3 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.8 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.9 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.4 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 3.2 PID P73PATHWAY p73 transcription factor network
0.0 10.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 6.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 1.1 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 21.3 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
3.5 74.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
2.7 133.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
2.6 28.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
2.6 53.6 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
1.4 16.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
1.3 29.2 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
1.3 5.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
1.0 42.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.9 20.8 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.7 43.7 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.5 7.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 3.6 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 17.4 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.4 16.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 31.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.4 11.8 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.4 23.1 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 18.3 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 6.9 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.3 13.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 8.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.3 37.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.3 4.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.3 9.9 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.3 20.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 7.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.3 5.7 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 5.6 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.2 1.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 3.0 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.2 10.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.2 3.7 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 4.1 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 1.5 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 14.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 6.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 3.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 16.3 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 2.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 3.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 19.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 5.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 10.4 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.2 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 7.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 8.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 9.5 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.1 4.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 2.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.1 1.1 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 7.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 4.1 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.1 1.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 0.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 1.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 2.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 1.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 4.8 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.0 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.0 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 2.8 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 2.9 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 1.1 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 1.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides