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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NFKB1
Z-value: 1.37
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Transcription factors associated with NFKB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB1 | hg38_v1_chr4_+_102501885_102501957, hg38_v1_chr4_+_102501298_102501474 | 0.33 | 7.1e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 83.7 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 8.8 | 61.8 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 0.4 | 59.2 | GO:0060333 | interferon-gamma-mediated signaling pathway(GO:0060333) |
| 19.3 | 58.0 | GO:1990108 | protein linear deubiquitination(GO:1990108) |
| 18.0 | 53.9 | GO:0072573 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
| 17.4 | 52.1 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 12.2 | 48.7 | GO:1900169 | regulation of glucocorticoid mediated signaling pathway(GO:1900169) |
| 4.2 | 46.2 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 7.2 | 43.5 | GO:0051138 | positive regulation of NK T cell differentiation(GO:0051138) |
| 1.7 | 29.9 | GO:0032688 | negative regulation of interferon-beta production(GO:0032688) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 123.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 5.6 | 105.7 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 4.9 | 63.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 1.2 | 58.0 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.2 | 56.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.7 | 49.2 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.5 | 47.2 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.3 | 37.4 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.1 | 34.7 | GO:0000323 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.4 | 28.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 111.9 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.3 | 100.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.1 | 89.7 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 4.5 | 53.6 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 7.4 | 52.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 3.7 | 51.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 3.9 | 46.3 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.9 | 45.3 | GO:0001205 | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205) |
| 6.6 | 39.4 | GO:0046979 | TAP2 binding(GO:0046979) |
| 0.1 | 32.3 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 180.0 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.1 | 70.5 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 1.3 | 65.1 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.5 | 45.0 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.9 | 38.9 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 1.7 | 37.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 26.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 1.0 | 25.9 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.3 | 22.9 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.4 | 20.0 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 133.8 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 3.5 | 74.4 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 2.6 | 53.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.7 | 43.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.0 | 42.2 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 37.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.4 | 31.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.3 | 29.2 | REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX | Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex |
| 2.6 | 28.6 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.4 | 23.1 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |