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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NFKB2
Z-value: 1.31
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Transcription factors associated with NFKB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFKB2 | hg38_v1_chr10_+_102395693_102395777 | 0.49 | 1.6e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NFKB2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 78.4 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.7 | 72.7 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 3.8 | 48.8 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 4.3 | 47.5 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.4 | 33.9 | GO:0031295 | T cell costimulation(GO:0031295) |
| 2.3 | 29.7 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 1.8 | 29.5 | GO:0060056 | mammary gland involution(GO:0060056) |
| 1.0 | 28.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 2.2 | 28.1 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 9.2 | 27.7 | GO:2000752 | regulation of phospholipid scramblase activity(GO:1900161) positive regulation of phospholipid scramblase activity(GO:1900163) regulation of glucosylceramide catabolic process(GO:2000752) positive regulation of glucosylceramide catabolic process(GO:2000753) regulation of sphingomyelin catabolic process(GO:2000754) positive regulation of sphingomyelin catabolic process(GO:2000755) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 70.0 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.3 | 65.7 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 15.5 | 62.0 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.6 | 48.9 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 2.0 | 48.8 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 40.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 38.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.9 | 36.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.6 | 29.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.3 | 28.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 98.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.4 | 71.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 65.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 8.9 | 62.0 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 2.2 | 48.8 | GO:0008494 | translation activator activity(GO:0008494) |
| 8.7 | 43.5 | GO:0034988 | Fc-gamma receptor I complex binding(GO:0034988) |
| 1.0 | 41.2 | GO:0019956 | chemokine binding(GO:0019956) |
| 1.5 | 39.3 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 2.6 | 36.0 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 35.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 69.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 1.3 | 65.4 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.6 | 37.0 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.8 | 36.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.4 | 26.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.8 | 25.2 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.5 | 19.7 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.4 | 18.7 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 1.0 | 18.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 16.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 80.2 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.9 | 60.3 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 1.6 | 58.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 1.7 | 46.4 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |
| 1.1 | 45.5 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 1.2 | 38.6 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.9 | 26.1 | REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| 1.9 | 26.0 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.7 | 25.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.7 | 24.3 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |