ISMARA results: NHLH1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NHLH1

Z-value: 1.52

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Transcription factors associated with NHLH1

Gene Symbol	Gene ID	Gene Info
NHLH1 Ensembl NCBI GeneCards UniProt	ENSG00000171786.6	NHLH1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NHLH1	hg38_v1_chr1_+_160367061_160367078	0.19	4.3e-03	Click!

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_23835946 Show fit	65.57	ENST00000321728.12 ENST00000643927.1	PRKCB Ensembl NCBI GeneCards UniProt Show fit	protein kinase C beta
chr13_-_36131286 Show fit	32.98	ENST00000255448.8 ENST00000379892.4	DCLK1 Ensembl NCBI GeneCards UniProt Show fit	doublecortin like kinase 1
chr14_-_23352741 Show fit	31.16	ENST00000354772.9	SLC22A17 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 22 member 17
chr8_+_24914942 Show fit	30.69	ENST00000433454.3	NEFM Ensembl NCBI GeneCards UniProt Show fit	neurofilament medium
chr10_+_103277129 Show fit	29.86	ENST00000369849.9	INA Ensembl NCBI GeneCards UniProt Show fit	internexin neuronal intermediate filament protein alpha
chr6_-_83709019 Show fit	27.26	ENST00000519779.5 ENST00000369694.6 ENST00000195649.10	SNAP91 Ensembl NCBI GeneCards UniProt Show fit	synaptosome associated protein 91
chr14_+_99684283 Show fit	27.26	ENST00000261835.8	CYP46A1 Ensembl NCBI GeneCards UniProt Show fit	cytochrome P450 family 46 subfamily A member 1
chr1_+_10210562 Show fit	24.91	ENST00000377093.9 ENST00000676179.1	KIF1B Ensembl NCBI GeneCards UniProt Show fit	kinesin family member 1B
chr6_-_83709141 Show fit	24.82	ENST00000521743.5	SNAP91 Ensembl NCBI GeneCards UniProt Show fit	synaptosome associated protein 91
chr6_-_3157536 Show fit	24.23	ENST00000333628.4	TUBB2A Ensembl NCBI GeneCards UniProt Show fit	tubulin beta 2A class IIa

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.4	80.3	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
13.1	65.6	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.8	57.0	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
1.2	51.9	GO:0021952	central nervous system projection neuron axonogenesis(GO:0021952)
12.3	49.4	GO:0033693	neurofilament bundle assembly(GO:0033693)
9.5	47.5	GO:0015891	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
2.9	47.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
7.5	44.8	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
1.5	38.7	GO:0006706	steroid catabolic process(GO:0006706)
8.9	35.6	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)

Showing 1 to 10 of 214 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	90.0	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
5.0	79.2	GO:0005883	neurofilament(GO:0005883)
0.3	68.4	GO:0005802	trans-Golgi network(GO:0005802)
0.6	63.4	GO:0005905	clathrin-coated pit(GO:0005905)
0.6	48.2	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
2.2	47.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.1	46.2	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
1.8	44.8	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.3	40.0	GO:0043204	perikaryon(GO:0043204)
0.1	38.9	GO:0031301	integral component of organelle membrane(GO:0031301)

Showing 1 to 10 of 99 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	118.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.7	70.1	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
16.4	65.6	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)
0.1	55.0	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
2.4	47.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
9.0	44.8	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.1	37.4	GO:0003924	GTPase activity(GO:0003924)
0.2	36.9	GO:0005057	receptor signaling protein activity(GO:0005057)
0.7	36.7	GO:0019894	kinesin binding(GO:0019894)
4.0	35.6	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)

Showing 1 to 10 of 142 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	65.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.7	35.6	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.9	35.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.4	33.1	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.5	32.4	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.7	27.7	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.4	20.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	20.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	19.8	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	17.1	PID S1P S1P3 PATHWAY	S1P3 pathway

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.0	78.9	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
1.7	55.2	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
1.3	51.0	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
1.1	48.9	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	39.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
2.4	28.3	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.8	23.8	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.5	21.8	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4	21.8	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
1.0	21.7	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation

Showing 1 to 10 of 57 entries

Results for NHLH1

Z-value: 1.52

Motif logo

Transcription factors associated with NHLH1

Activity-expression correlation:

Activity profile of NHLH1 motif

Sorted Z-values of NHLH1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NHLH1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: