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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX1-1
Z-value: 0.41
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Transcription factors associated with NKX1-1
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX1-1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 8.4 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 1.5 | 7.3 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.2 | 7.3 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.9 | 4.4 | GO:0061031 | endodermal digestive tract morphogenesis(GO:0061031) |
| 0.8 | 3.8 | GO:0046490 | isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate metabolic process(GO:0046490) |
| 1.2 | 3.5 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.1 | 3.5 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.2 | 3.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 0.1 | 3.0 | GO:0061157 | mRNA destabilization(GO:0061157) |
| 0.2 | 2.8 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 8.4 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 0.1 | 7.3 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 3.9 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 3.5 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 2.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 2.7 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.3 | 2.6 | GO:0061574 | ASAP complex(GO:0061574) |
| 0.0 | 2.2 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.2 | 2.0 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.3 | 1.9 | GO:0016272 | prefoldin complex(GO:0016272) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.5 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.5 | 7.3 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 1.2 | 7.3 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.0 | 4.0 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 3.9 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.3 | 3.8 | GO:0016863 | intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863) |
| 0.4 | 3.5 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.8 | 3.3 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.2 | 2.8 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 2.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 1.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 1.2 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 1.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 0.8 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 0.2 | PID MYC PATHWAY | C-MYC pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.7 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 7.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 4.6 | REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS | Genes involved in Interactions of Vpr with host cellular proteins |
| 0.1 | 3.5 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 3.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 2.6 | REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM | Genes involved in Transport of Mature Transcript to Cytoplasm |
| 0.0 | 2.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 2.0 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.0 | 1.9 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 0.1 | 1.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |