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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX1-2_RAX
Z-value: 0.63
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Transcription factors associated with NKX1-2_RAX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RAX | hg38_v1_chr18_-_59273447_59273459, hg38_v1_chr18_-_59273379_59273429 | -0.55 | 7.8e-19 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX1-2_RAX
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_25863537 Show fit | 18.87 |
ENST00000502949.5
ENST00000264868.9 ENST00000513691.1 ENST00000514872.1 |
SEL1L family member 3 |
|
| chr3_-_64019334 Show fit | 18.47 |
ENST00000480205.5
|
proteasome 26S subunit, non-ATPase 6 |
|
| chr7_-_88226965 Show fit | 15.29 |
ENST00000490437.5
ENST00000431660.5 |
sorcin |
|
| chr3_+_158801926 Show fit | 15.18 |
ENST00000622669.4
ENST00000392813.8 ENST00000415822.8 ENST00000651862.1 ENST00000264266.12 |
major facilitator superfamily domain containing 1 |
|
| chr7_-_88226987 Show fit | 15.11 |
ENST00000394641.7
|
sorcin |
|
| chr2_+_186506713 Show fit | 13.70 |
ENST00000445547.1
|
zinc finger CCCH-type containing 15 |
|
| chr10_+_123154768 Show fit | 13.67 |
ENST00000407911.2
|
BUB3 mitotic checkpoint protein |
|
| chr6_+_106360668 Show fit | 11.89 |
ENST00000633556.3
|
crystallin beta-gamma domain containing 1 |
|
| chr4_-_102828022 Show fit | 10.93 |
ENST00000502690.5
|
ubiquitin conjugating enzyme E2 D3 |
|
| chr4_-_102828048 Show fit | 9.97 |
ENST00000508249.1
|
ubiquitin conjugating enzyme E2 D3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 32.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 4.3 | 30.4 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.7 | 28.8 | GO:0071173 | mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173) |
| 0.2 | 18.5 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 0.8 | 16.3 | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) |
| 4.4 | 13.2 | GO:0036466 | synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149) |
| 0.4 | 13.0 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 2.4 | 11.8 | GO:0045337 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 0.3 | 7.6 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.3 | 6.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 30.4 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 9.6 | 28.8 | GO:1990298 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.0 | 25.3 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.6 | 18.5 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.1 | 13.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 9.0 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 7.6 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.3 | 5.8 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.0 | 5.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.9 | 5.7 | GO:0061617 | MICOS complex(GO:0061617) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 34.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 33.0 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.8 | 30.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 4.1 | 16.3 | GO:0000026 | alpha-1,2-mannosyltransferase activity(GO:0000026) |
| 0.0 | 13.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.7 | 13.2 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 13.0 | GO:0016887 | ATPase activity(GO:0016887) |
| 2.4 | 11.8 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.0 | 7.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.3 | 6.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 34.6 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.2 | 33.7 | PID P73PATHWAY | p73 transcription factor network |
| 0.1 | 4.5 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 4.5 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.1 | 4.0 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 3.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.0 | 2.3 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.0 | 2.0 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 0.0 | 1.9 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.1 | 1.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 34.6 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 1.2 | 33.0 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.3 | 18.5 | REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C | Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C |
| 0.4 | 14.2 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 13.2 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 0.2 | 6.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 5.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 5.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 5.1 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 5.1 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |