ISMARA results: NKX2-2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX2-2

Z-value: 1.31

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Transcription factors associated with NKX2-2

Gene Symbol	Gene ID	Gene Info
NKX2-2 Ensembl NCBI GeneCards UniProt	ENSG00000125820.6	NKX2-2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NKX2-2	hg38_v1_chr20_-_21514046_21514070	-0.13	6.5e-02	Click!

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr3_-_64019334 Show fit	40.16	ENST00000480205.5	PSMD6 Ensembl NCBI GeneCards UniProt Show fit	proteasome 26S subunit, non-ATPase 6
chr11_-_11353241 Show fit	35.48	ENST00000528848.3	CSNK2A3 Ensembl NCBI GeneCards UniProt Show fit	casein kinase 2 alpha 3
chr3_+_159273235 Show fit	33.64	ENST00000638749.1	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	IQCJ-SCHIP1 readthrough
chr8_-_100950549 Show fit	28.52	ENST00000395951.7	YWHAZ Ensembl NCBI GeneCards UniProt Show fit	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chrX_+_71254781 Show fit	28.50	ENST00000677446.1	NONO Ensembl NCBI GeneCards UniProt Show fit	non-POU domain containing octamer binding
chr5_+_160421847 Show fit	28.20	ENST00000352433.10 ENST00000517480.1 ENST00000520452.5 ENST00000393964.1	PTTG1 Ensembl NCBI GeneCards UniProt Show fit	PTTG1 regulator of sister chromatid separation, securin
chr1_-_53940100 Show fit	27.97	ENST00000371376.1	HSPB11 Ensembl NCBI GeneCards UniProt Show fit	heat shock protein family B (small) member 11
chr2_-_150487658 Show fit	27.82	ENST00000375734.6 ENST00000263895.9 ENST00000454202.5	RND3 Ensembl NCBI GeneCards UniProt Show fit	Rho family GTPase 3
chr2_+_169798841 Show fit	25.47	ENST00000260956.9 ENST00000417292.5	SSB Ensembl NCBI GeneCards UniProt Show fit	small RNA binding exonuclease protection factor La
chr9_+_128685062 Show fit	24.79	ENST00000409104.7	SET Ensembl NCBI GeneCards UniProt Show fit	SET nuclear proto-oncogene

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	62.5	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
8.9	53.4	GO:0006696	ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
2.2	51.9	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.6	51.2	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
1.6	43.7	GO:0043968	histone H2A acetylation(GO:0043968)
0.5	37.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.8	36.5	GO:0006376	mRNA splice site selection(GO:0006376)
7.1	35.5	GO:0044111	development involved in symbiotic interaction(GO:0044111)
2.1	32.0	GO:0070986	left/right axis specification(GO:0070986)
0.1	31.5	GO:0045732	positive regulation of protein catabolic process(GO:0045732)

Showing 1 to 10 of 123 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	63.0	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.4	45.8	GO:0005796	Golgi lumen(GO:0005796)
0.1	43.8	GO:0005925	focal adhesion(GO:0005925)
1.3	40.2	GO:0005838	proteasome regulatory particle(GO:0005838)
0.3	37.1	GO:0031985	Golgi cisterna(GO:0031985)
0.9	37.0	GO:0005762	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.7	36.0	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
1.7	35.8	GO:0071004	U2-type prespliceosome(GO:0071004)
1.6	32.8	GO:0016580	Sin3 complex(GO:0016580)
0.3	31.0	GO:0005604	basement membrane(GO:0005604)

Showing 1 to 10 of 82 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	83.4	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
8.9	53.4	GO:0004310	farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
1.4	51.6	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	46.0	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
1.7	38.1	GO:0008494	translation activator activity(GO:0008494)
0.1	29.3	GO:0003924	GTPase activity(GO:0003924)
0.3	28.5	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
3.5	28.2	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.4	28.2	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.6	28.0	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	72.5	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
1.3	44.7	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.6	30.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	29.4	PID CDC42 PATHWAY	CDC42 signaling events
1.5	28.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	25.4	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.3	21.5	PID RHOA PATHWAY	RhoA signaling pathway
0.2	19.1	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.2	18.8	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	18.8	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Showing 1 to 10 of 36 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	106.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.3	53.4	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.3	52.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.7	46.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.1	38.1	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
1.1	28.5	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.7	25.5	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
1.4	24.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.8	23.0	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.6	22.3	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions

Showing 1 to 10 of 52 entries

Results for NKX2-2

Z-value: 1.31

Motif logo

Transcription factors associated with NKX2-2

Activity-expression correlation:

Activity profile of NKX2-2 motif

Sorted Z-values of NKX2-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX2-2

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: