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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX2-3
Z-value: 0.87
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Transcription factors associated with NKX2-3
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.0 | 63.0 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 3.3 | 33.0 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.3 | 15.8 | GO:0006069 | ethanol oxidation(GO:0006069) |
| 0.1 | 14.3 | GO:0007030 | Golgi organization(GO:0007030) |
| 2.3 | 14.1 | GO:0051945 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 11.6 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.7 | 11.2 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 2.2 | 10.8 | GO:1901628 | NMDA glutamate receptor clustering(GO:0097114) positive regulation of postsynaptic membrane organization(GO:1901628) positive regulation of dendritic spine maintenance(GO:1902952) |
| 0.1 | 10.4 | GO:0009988 | cell-cell recognition(GO:0009988) |
| 0.3 | 10.3 | GO:0097503 | sialylation(GO:0097503) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 83.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 38.3 | GO:0031430 | M band(GO:0031430) |
| 0.9 | 14.0 | GO:0045277 | respiratory chain complex IV(GO:0045277) |
| 0.4 | 13.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 2.7 | 10.8 | GO:0034365 | discoidal high-density lipoprotein particle(GO:0034365) |
| 1.6 | 9.8 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 9.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 8.6 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.2 | 8.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.1 | 7.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 63.0 | GO:0008430 | selenium binding(GO:0008430) |
| 0.5 | 33.0 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 16.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.0 | 15.8 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.0 | 14.8 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 2.3 | 14.1 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 13.9 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 11.0 | GO:0005179 | hormone activity(GO:0005179) |
| 2.7 | 10.8 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 3.4 | 10.3 | GO:0052798 | beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 12.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 8.7 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 7.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 7.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.6 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.1 | 4.8 | PID SYNDECAN 1 PATHWAY | Syndecan-1-mediated signaling events |
| 0.1 | 4.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 4.5 | PID P73PATHWAY | p73 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 15.8 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.3 | 14.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.6 | 12.7 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.5 | 12.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.4 | 10.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.3 | 9.9 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 9.9 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.5 | 9.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.4 | 8.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.4 | 8.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |