Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for NKX2-4
Z-value: 0.76
Motif logo
Transcription factors associated with NKX2-4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-4 | hg38_v1_chr20_-_21397513_21397531 | -0.17 | 1.1e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.8 | GO:0007127 | meiosis I(GO:0007127) |
| 0.9 | 8.2 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) |
| 0.8 | 5.6 | GO:1902963 | regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) |
| 0.8 | 4.7 | GO:0071896 | protein localization to adherens junction(GO:0071896) |
| 0.8 | 4.6 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.3 | 4.6 | GO:0031274 | positive regulation of pseudopodium assembly(GO:0031274) |
| 0.0 | 4.6 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.6 | 4.4 | GO:0051013 | microtubule severing(GO:0051013) |
| 0.3 | 3.9 | GO:0030321 | transepithelial chloride transport(GO:0030321) |
| 0.2 | 3.9 | GO:0003334 | keratinocyte development(GO:0003334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 10.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 10.1 | GO:0005884 | actin filament(GO:0005884) |
| 1.0 | 9.7 | GO:0097197 | tetraspanin-enriched microdomain(GO:0097197) |
| 0.6 | 7.9 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.1 | 6.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 1.1 | 5.6 | GO:0070381 | endosome to plasma membrane transport vesicle(GO:0070381) |
| 0.1 | 5.4 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.2 | 4.7 | GO:0097025 | MPP7-DLG1-LIN7 complex(GO:0097025) |
| 0.0 | 4.4 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.5 | 8.2 | GO:1901612 | cardiolipin binding(GO:1901612) |
| 0.0 | 6.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.4 | 5.6 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.2 | 4.9 | GO:0005522 | profilin binding(GO:0005522) |
| 1.5 | 4.6 | GO:0005519 | cytoskeletal regulatory protein binding(GO:0005519) |
| 0.0 | 4.5 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.6 | 4.4 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.4 | 4.4 | GO:0031433 | telethonin binding(GO:0031433) |
| 0.0 | 4.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 7.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 4.6 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 4.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 4.3 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 4.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 3.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.5 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 2.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 4.6 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 4.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.3 | 4.1 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 3.7 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 3.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.1 | 2.9 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 2.9 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 0.1 | 2.4 | REACTOME PROCESSING OF INTRONLESS PRE MRNAS | Genes involved in Processing of Intronless Pre-mRNAs |
| 0.1 | 2.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |