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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX2-5
Z-value: 0.95
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Transcription factors associated with NKX2-5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX2-5 | hg38_v1_chr5_-_173235194_173235213 | 0.05 | 5.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX2-5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 42.8 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 1.5 | 32.3 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 1.3 | 21.7 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 4.3 | 17.1 | GO:1901339 | regulation of store-operated calcium channel activity(GO:1901339) |
| 1.4 | 16.2 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 14.2 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.7 | 13.9 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.9 | 13.9 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) positive regulation of lamellipodium morphogenesis(GO:2000394) |
| 0.7 | 11.0 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 1.2 | 10.9 | GO:0072344 | rescue of stalled ribosome(GO:0072344) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 63.1 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 61.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.3 | 38.3 | GO:0031514 | motile cilium(GO:0031514) |
| 2.8 | 19.7 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.0 | 17.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 15.4 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 13.4 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.1 | 9.1 | GO:1990391 | DNA repair complex(GO:1990391) |
| 0.1 | 8.5 | GO:0005901 | caveola(GO:0005901) |
| 0.8 | 8.4 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 42.8 | GO:0031432 | titin binding(GO:0031432) |
| 0.7 | 32.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.1 | 20.0 | GO:0005179 | hormone activity(GO:0005179) |
| 1.9 | 17.1 | GO:0047499 | calcium-independent phospholipase A2 activity(GO:0047499) |
| 2.8 | 16.6 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 3.5 | 13.9 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.4 | 12.6 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.2 | 11.4 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.2 | 10.9 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 1.8 | 9.1 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.8 | 13.9 | PID THROMBIN PAR4 PATHWAY | PAR4-mediated thrombin signaling events |
| 0.2 | 9.3 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.2 | 9.1 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 7.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.1 | 6.8 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.3 | 6.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 5.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 3.4 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 3.2 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.7 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.8 | 18.4 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 0.4 | 13.9 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.1 | 12.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.8 | 9.1 | REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY | Genes involved in Regulation of the Fanconi anemia pathway |
| 0.4 | 8.6 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.4 | 8.2 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.1 | 8.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.6 | 8.1 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.8 | 6.3 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |