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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX3-1
Z-value: 0.65
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Transcription factors associated with NKX3-1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX3-1 | hg38_v1_chr8_-_23682889_23682951 | -0.24 | 3.0e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX3-1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 17.5 | GO:0048208 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 0.0 | 14.2 | GO:0007264 | small GTPase mediated signal transduction(GO:0007264) |
| 0.9 | 13.5 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 2.2 | 11.2 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 1.8 | 10.9 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.2 | 10.3 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.4 | 9.9 | GO:0051639 | actin filament network formation(GO:0051639) |
| 0.2 | 9.6 | GO:0009250 | glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250) |
| 2.2 | 8.6 | GO:1900535 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 0.2 | 8.6 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 40.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.7 | 20.1 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 0.1 | 12.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.4 | 10.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 10.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 10.1 | GO:0005777 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.1 | 9.8 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.9 | 7.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.5 | 7.1 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.2 | 6.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 16.3 | GO:0042802 | identical protein binding(GO:0042802) |
| 0.1 | 10.9 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 10.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 10.7 | GO:0005525 | GTP binding(GO:0005525) |
| 1.0 | 10.3 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 1.0 | 8.6 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.4 | 8.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 7.9 | GO:0004553 | hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553) |
| 1.9 | 7.7 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.2 | 12.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.0 | 8.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.0 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 7.2 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.1 | 6.3 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 5.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.1 | 5.5 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.2 | 4.7 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 4.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.7 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.6 | 11.2 | REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX | Genes involved in Association of licensing factors with the pre-replicative complex |
| 0.1 | 11.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.2 | 8.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.2 | 8.0 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 7.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 7.1 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.1 | 6.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.2 | 6.1 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 5.9 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |