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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX3-2
Z-value: 0.98
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Transcription factors associated with NKX3-2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX3-2 | hg38_v1_chr4_-_13544506_13544513 | 0.19 | 5.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX3-2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 66.5 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 31.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 5.9 | 23.6 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 6.7 | 20.2 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 0.2 | 20.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.3 | 15.0 | GO:0033198 | response to ATP(GO:0033198) |
| 0.2 | 13.1 | GO:0046426 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.2 | 13.1 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) |
| 0.0 | 12.2 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.2 | 12.1 | GO:0042100 | B cell proliferation(GO:0042100) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 66.5 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 3.0 | 57.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 21.7 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.3 | 14.9 | GO:0016235 | aggresome(GO:0016235) |
| 0.3 | 13.9 | GO:0000791 | euchromatin(GO:0000791) |
| 0.1 | 13.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 13.1 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 11.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 1.5 | 10.4 | GO:0008282 | ATP-sensitive potassium channel complex(GO:0008282) |
| 0.3 | 9.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 66.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.4 | 35.7 | GO:0023026 | MHC class II protein complex binding(GO:0023026) |
| 0.1 | 27.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.5 | 24.7 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.1 | 20.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.9 | 20.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.5 | 13.9 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 1.5 | 13.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 12.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 11.8 | GO:0004888 | transmembrane signaling receptor activity(GO:0004888) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 27.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.4 | 23.3 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 20.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 13.9 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
| 0.0 | 10.5 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 9.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 9.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 9.3 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 8.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.1 | 8.2 | PID BCR 5PATHWAY | BCR signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 24.7 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 1.1 | 23.6 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.2 | 20.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 16.3 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 0.3 | 10.0 | REACTOME HS GAG BIOSYNTHESIS | Genes involved in HS-GAG biosynthesis |
| 0.1 | 9.4 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.4 | 8.8 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.2 | 8.6 | REACTOME GAB1 SIGNALOSOME | Genes involved in GAB1 signalosome |
| 0.1 | 8.5 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.3 | 8.2 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |