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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX6-2

Z-value: 0.90

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Transcription factors associated with NKX6-2

Gene Symbol Gene ID Gene Info
NKX6-2
ENSG00000148826.9 NKX6-2

Activity profile of NKX6-2 motif

Sorted Z-values of NKX6-2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_41256921 29.29 ENST00000284440.9
ENST00000508768.5
ENST00000512788.1
UCHL1
ubiquitin C-terminal hydrolase L1
chr14_-_59630806 26.04 ENST00000342503.8
RTN1
reticulon 1
chr14_-_59630582 24.50 ENST00000395090.5
RTN1
reticulon 1
chr4_+_87975667 23.53 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
SPP1
secreted phosphoprotein 1
chr3_+_39467672 23.19 ENST00000436143.6
ENST00000441980.6
ENST00000682069.1
ENST00000311042.10
MOBP
myelin associated oligodendrocyte basic protein
chr3_+_39467598 22.57 ENST00000428261.5
ENST00000420739.5
ENST00000415443.5
ENST00000447324.5
ENST00000383754.7
MOBP
myelin associated oligodendrocyte basic protein
chr3_-_98522514 21.99 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
CLDND1
claudin domain containing 1
chr2_-_174847765 21.39 ENST00000443238.6
CHN1
chimerin 1
chr17_-_44915486 21.19 ENST00000638281.1
ENST00000588316.1
ENST00000588735.3
ENST00000639277.1
ENST00000253408.11
ENST00000435360.8
ENST00000586793.6
ENST00000588037.1
ENST00000592320.6
GFAP
glial fibrillary acidic protein
chr2_-_174847525 19.07 ENST00000295497.12
ENST00000652036.1
ENST00000444394.6
ENST00000650731.1
CHN1
chimerin 1
chr11_-_5227063 15.72 ENST00000335295.4
ENST00000485743.1
ENST00000647020.1
HBB
hemoglobin subunit beta
chr12_+_6914571 14.57 ENST00000229277.6
ENST00000538763.5
ENST00000545045.6
ENO2
enolase 2
chr7_-_137343752 13.64 ENST00000393083.2
PTN
pleiotrophin
chr13_-_35855758 13.62 ENST00000615680.4
DCLK1
doublecortin like kinase 1
chr4_-_89838289 13.46 ENST00000336904.7
SNCA
synuclein alpha
chr13_-_44474296 13.27 ENST00000611198.4
TSC22D1
TSC22 domain family member 1
chr16_+_56191476 12.35 ENST00000262493.12
GNAO1
G protein subunit alpha o1
chr3_+_319683 12.25 ENST00000620033.4
CHL1
cell adhesion molecule L1 like
chr2_+_232662733 10.42 ENST00000410095.5
ENST00000611312.1
EFHD1
EF-hand domain family member D1
chr3_+_159839847 9.69 ENST00000445224.6
SCHIP1
schwannomin interacting protein 1
chr14_-_26598025 9.53 ENST00000539517.7
NOVA1
NOVA alternative splicing regulator 1
chr5_+_161848314 9.17 ENST00000437025.6
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr4_-_86453075 9.12 ENST00000641384.1
ENST00000642009.1
ENST00000641274.1
ENST00000641629.1
ENST00000641718.1
ENST00000641782.1
ENST00000511328.5
ENST00000503911.5
ENST00000641862.1
ENST00000640445.1
ENST00000641675.1
ENST00000361569.8
ENST00000639989.2
ENST00000641120.1
ENST00000642023.1
ENST00000641902.1
ENST00000641016.1
ENST00000509464.7
ENST00000638946.2
ENST00000395160.9
ENST00000512017.7
ENST00000639972.2
MAPK10
mitogen-activated protein kinase 10
chrX_+_103585478 9.10 ENST00000468024.5
ENST00000415568.2
ENST00000472484.6
ENST00000613326.4
ENST00000490644.5
ENST00000459722.1
ENST00000472745.1
ENST00000494801.5
ENST00000434216.2
TCEAL4
transcription elongation factor A like 4
chr18_-_55587335 8.91 ENST00000638154.3
TCF4
transcription factor 4
chr22_+_28742024 8.20 ENST00000216027.8
ENST00000398941.6
HSCB
HscB mitochondrial iron-sulfur cluster cochaperone
chr7_-_36985060 8.18 ENST00000396040.6
ELMO1
engulfment and cell motility 1
chr2_-_73293538 7.78 ENST00000436467.4
ENST00000545030.1
EGR4
early growth response 4
chr10_-_72088533 7.68 ENST00000373109.7
SPOCK2
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr6_-_56851888 6.06 ENST00000312431.10
ENST00000520645.5
DST
dystonin
chr5_-_20575850 5.95 ENST00000507958.5
CDH18
cadherin 18
chr5_+_161848112 5.72 ENST00000393943.10
GABRA1
gamma-aminobutyric acid type A receptor subunit alpha1
chr16_+_14708944 5.61 ENST00000526520.5
ENST00000531598.6
NPIPA3
nuclear pore complex interacting protein family member A3
chr10_-_69409275 5.56 ENST00000373307.5
TACR2
tachykinin receptor 2
chr4_+_54229261 5.28 ENST00000508170.5
ENST00000512143.1
ENST00000257290.10
PDGFRA
platelet derived growth factor receptor alpha
chr5_-_56116946 5.00 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr6_+_158312459 4.98 ENST00000367097.8
TULP4
TUB like protein 4
chr17_-_75667088 4.89 ENST00000578201.5
ENST00000423245.6
ENST00000317905.10
RECQL5
RecQ like helicase 5
chr19_+_12064720 4.79 ENST00000550826.1
ENST00000439326.8
ZNF844
zinc finger protein 844
chr8_+_78516329 4.60 ENST00000396418.7
ENST00000352966.9
PKIA
cAMP-dependent protein kinase inhibitor alpha
chr2_+_68734861 4.59 ENST00000467265.5
ARHGAP25
Rho GTPase activating protein 25
chrX_+_10156960 4.47 ENST00000380833.9
CLCN4
chloride voltage-gated channel 4
chr16_+_14748066 4.44 ENST00000530328.5
ENST00000529166.5
NPIPA2
nuclear pore complex interacting protein family member A2
chr1_-_158554405 4.42 ENST00000641282.1
ENST00000641622.1
OR6Y1
olfactory receptor family 6 subfamily Y member 1
chr3_-_79767987 4.27 ENST00000464233.6
ROBO1
roundabout guidance receptor 1
chr19_+_54137740 4.15 ENST00000644245.1
ENST00000646002.1
ENST00000221232.11
ENST00000440571.6
ENST00000617930.2
CNOT3
CCR4-NOT transcription complex subunit 3
chr2_+_172928165 4.11 ENST00000535187.5
RAPGEF4
Rap guanine nucleotide exchange factor 4
chrX_+_136148440 4.09 ENST00000627383.2
ENST00000630084.2
FHL1
four and a half LIM domains 1
chr4_+_187995764 4.06 ENST00000509524.5
ENST00000326866.5
ZFP42
ZFP42 zinc finger protein
chr7_+_77696423 3.99 ENST00000334955.13
RSBN1L
round spermatid basic protein 1 like
chr19_+_52269579 3.97 ENST00000593703.1
ENST00000439461.6
ENST00000601711.5
ENST00000599581.5
ZNF766
zinc finger protein 766
chr2_+_209579399 3.95 ENST00000360351.8
MAP2
microtubule associated protein 2
chr1_-_226739271 3.95 ENST00000429204.6
ENST00000366784.1
ITPKB
inositol-trisphosphate 3-kinase B
chr5_+_162067990 3.92 ENST00000641017.1
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr1_+_180632001 3.85 ENST00000367590.9
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr21_-_35049327 3.74 ENST00000300305.7
RUNX1
RUNX family transcription factor 1
chr14_-_26597430 3.74 ENST00000344429.9
ENST00000574031.1
ENST00000465357.6
ENST00000547619.5
NOVA1
NOVA alternative splicing regulator 1
chr12_+_101594849 3.68 ENST00000547405.5
ENST00000452455.6
ENST00000392934.7
ENST00000547509.5
ENST00000361685.6
ENST00000549145.5
ENST00000361466.7
ENST00000553190.5
ENST00000545503.6
ENST00000536007.5
ENST00000541119.5
ENST00000551300.5
ENST00000550270.1
MYBPC1
myosin binding protein C1
chrX_-_49043345 3.66 ENST00000315869.8
TFE3
transcription factor binding to IGHM enhancer 3
chr18_+_44680093 3.65 ENST00000426838.8
ENST00000677068.1
SETBP1
SET binding protein 1
chr9_+_79571956 3.61 ENST00000376552.8
TLE4
TLE family member 4, transcriptional corepressor
chr7_-_22193824 3.61 ENST00000401957.6
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr2_-_216694794 3.60 ENST00000449583.1
IGFBP5
insulin like growth factor binding protein 5
chr21_-_35049238 3.56 ENST00000416754.1
ENST00000437180.5
ENST00000455571.5
ENST00000675419.1
RUNX1
RUNX family transcription factor 1
chr5_+_68290637 3.44 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr12_+_104986292 3.42 ENST00000552951.7
ENST00000637147.1
ENST00000622317.5
ENST00000280749.5
C12orf45
chromosome 12 open reading frame 45
chr17_-_75667165 3.41 ENST00000584999.1
ENST00000420326.6
ENST00000340830.9
RECQL5
RecQ like helicase 5
chr5_+_162068031 3.37 ENST00000356592.8
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr9_-_23826299 3.33 ENST00000380117.5
ELAVL2
ELAV like RNA binding protein 2
chr1_+_114854858 3.32 ENST00000369522.8
ENST00000455987.5
ENST00000618516.4
ENST00000613524.4
SYCP1
synaptonemal complex protein 1
chr8_-_90082871 3.32 ENST00000265431.7
CALB1
calbindin 1
chr2_+_209579429 3.26 ENST00000361559.8
MAP2
microtubule associated protein 2
chr3_-_138329839 3.25 ENST00000333911.9
ENST00000383180.6
NME9
NME/NM23 family member 9
chr11_-_62754141 3.24 ENST00000527994.1
ENST00000394807.5
ENST00000673933.1
ZBTB3
zinc finger and BTB domain containing 3
chr1_-_149886652 3.23 ENST00000369155.3
H2BC21
H2B clustered histone 21
chr9_-_23826231 3.16 ENST00000397312.7
ELAVL2
ELAV like RNA binding protein 2
chr18_+_79069385 3.06 ENST00000426216.6
ENST00000307671.12
ENST00000586672.5
ENST00000586722.5
ATP9B
ATPase phospholipid transporting 9B (putative)
chr5_+_95731300 2.98 ENST00000379982.8
RHOBTB3
Rho related BTB domain containing 3
chrX_-_31178220 2.92 ENST00000681026.1
DMD
dystrophin
chr2_-_216695540 2.89 ENST00000233813.5
IGFBP5
insulin like growth factor binding protein 5
chrX_-_31178149 2.89 ENST00000679437.1
DMD
dystrophin
chr14_+_88385643 2.83 ENST00000393545.9
ENST00000356583.9
ENST00000555401.5
ENST00000553885.5
SPATA7
spermatogenesis associated 7
chr2_+_209579598 2.62 ENST00000445941.5
ENST00000673860.1
MAP2
microtubule associated protein 2
chr12_-_109021015 2.54 ENST00000546618.2
ENST00000610966.5
SVOP
SV2 related protein
chr13_-_33185994 2.49 ENST00000255486.8
STARD13
StAR related lipid transfer domain containing 13
chr15_-_48811038 2.47 ENST00000380950.7
CEP152
centrosomal protein 152
chr2_+_201183120 2.39 ENST00000272879.9
ENST00000286186.11
ENST00000374650.7
ENST00000346817.9
ENST00000313728.11
ENST00000448480.1
CASP10
caspase 10
chr12_-_54984667 2.33 ENST00000524668.5
ENST00000533607.1
ENST00000449076.6
TESPA1
thymocyte expressed, positive selection associated 1
chr3_+_130931893 2.32 ENST00000504612.5
ATP2C1
ATPase secretory pathway Ca2+ transporting 1
chr12_-_55296569 2.26 ENST00000358433.3
OR6C6
olfactory receptor family 6 subfamily C member 6
chr5_+_162067858 2.20 ENST00000361925.9
GABRG2
gamma-aminobutyric acid type A receptor subunit gamma2
chr2_+_210477708 2.17 ENST00000673711.1
CPS1
carbamoyl-phosphate synthase 1
chr18_-_500692 2.11 ENST00000400256.5
COLEC12
collectin subfamily member 12
chr5_-_146878595 2.02 ENST00000394409.7
PPP2R2B
protein phosphatase 2 regulatory subunit Bbeta
chr15_-_48810987 2.01 ENST00000399334.7
ENST00000325747.9
CEP152
centrosomal protein 152
chr7_-_108240049 1.99 ENST00000379022.8
NRCAM
neuronal cell adhesion molecule
chr21_-_26090035 1.90 ENST00000448850.5
APP
amyloid beta precursor protein
chr2_+_210477676 1.90 ENST00000673510.1
ENST00000673630.1
ENST00000430249.7
CPS1
carbamoyl-phosphate synthase 1
chr1_-_48776811 1.77 ENST00000371833.4
BEND5
BEN domain containing 5
chr17_-_42676980 1.74 ENST00000587627.1
ENST00000591022.6
ENST00000293349.10
PLEKHH3
pleckstrin homology, MyTH4 and FERM domain containing H3
chrX_+_55717733 1.73 ENST00000414239.5
ENST00000374941.9
RRAGB
Ras related GTP binding B
chr2_-_227379297 1.64 ENST00000304568.4
TM4SF20
transmembrane 4 L six family member 20
chr18_-_48950960 1.61 ENST00000262158.8
SMAD7
SMAD family member 7
chr3_-_45796467 1.61 ENST00000353278.8
ENST00000456124.6
SLC6A20
solute carrier family 6 member 20
chr11_+_122882683 1.56 ENST00000307257.10
ENST00000227349.7
JHY
junctional cadherin complex regulator
chr1_+_209704836 1.50 ENST00000367027.5
HSD11B1
hydroxysteroid 11-beta dehydrogenase 1
chr5_+_102808057 1.45 ENST00000684043.1
ENST00000682407.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr7_-_78771265 1.42 ENST00000630991.2
ENST00000629359.2
MAGI2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr2_-_74343397 1.39 ENST00000394019.6
ENST00000377634.8
ENST00000436454.1
SLC4A5
solute carrier family 4 member 5
chr5_-_111756245 1.32 ENST00000447165.6
NREP
neuronal regeneration related protein
chr8_+_24440930 1.27 ENST00000441335.6
ENST00000175238.10
ENST00000380789.5
ADAM7
ADAM metallopeptidase domain 7
chr2_-_178108339 1.22 ENST00000358450.8
PDE11A
phosphodiesterase 11A
chr3_-_45796518 1.22 ENST00000413781.1
ENST00000358525.9
SLC6A20
solute carrier family 6 member 20
chrX_+_55717796 1.21 ENST00000262850.7
RRAGB
Ras related GTP binding B
chr1_-_7940825 1.19 ENST00000377507.8
TNFRSF9
TNF receptor superfamily member 9
chr1_-_190477854 1.18 ENST00000367462.5
BRINP3
BMP/retinoic acid inducible neural specific 3
chr22_-_33572227 1.16 ENST00000674780.1
LARGE1
LARGE xylosyl- and glucuronyltransferase 1
chr17_+_59155726 1.14 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chrX_-_111410420 1.04 ENST00000371993.7
ENST00000680476.1
DCX
doublecortin
chr2_-_207165923 0.97 ENST00000309446.11
KLF7
Kruppel like factor 7
chr1_+_86547070 0.96 ENST00000370563.3
CLCA4
chloride channel accessory 4
chr8_+_103819244 0.96 ENST00000262231.14
ENST00000507740.5
ENST00000408894.6
RIMS2
regulating synaptic membrane exocytosis 2
chrX_-_81201886 0.95 ENST00000451455.1
ENST00000358130.7
ENST00000436386.5
HMGN5
high mobility group nucleosome binding domain 5
chrX_+_83508284 0.94 ENST00000644024.2
POU3F4
POU class 3 homeobox 4
chr3_-_115071333 0.93 ENST00000462705.5
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_143959927 0.86 ENST00000624504.1
OR2F1
olfactory receptor family 2 subfamily F member 1
chr9_-_21385395 0.71 ENST00000380206.4
IFNA2
interferon alpha 2
chr13_+_53028806 0.68 ENST00000219022.3
OLFM4
olfactomedin 4
chr18_+_34710249 0.67 ENST00000680346.1
ENST00000348997.9
ENST00000681274.1
ENST00000680822.1
ENST00000680767.2
ENST00000597599.5
ENST00000444659.6
DTNA
dystrobrevin alpha
chr18_-_55351977 0.64 ENST00000643689.1
TCF4
transcription factor 4
chr10_-_99235783 0.63 ENST00000370546.5
ENST00000614306.1
HPSE2
heparanase 2 (inactive)
chr20_+_43507668 0.63 ENST00000434666.5
ENST00000649084.1
ENST00000418998.7
ENST00000427442.8
ENST00000649917.1
L3MBTL1
L3MBTL histone methyl-lysine binding protein 1
chr9_+_35341830 0.56 ENST00000636694.1
UNC13B
unc-13 homolog B
chr15_-_89221558 0.54 ENST00000268125.10
RLBP1
retinaldehyde binding protein 1
chr16_+_19410723 0.53 ENST00000381414.8
ENST00000396229.6
TMC5
transmembrane channel like 5
chr6_-_130956371 0.53 ENST00000639623.1
ENST00000525193.5
ENST00000527659.5
EPB41L2
erythrocyte membrane protein band 4.1 like 2
chr1_-_150876697 0.50 ENST00000515192.5
ARNT
aryl hydrocarbon receptor nuclear translocator
chr15_+_92900189 0.48 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chrX_+_154304923 0.44 ENST00000426989.5
ENST00000426203.5
ENST00000369912.2
TKTL1
transketolase like 1
chr5_+_31193678 0.44 ENST00000265071.3
CDH6
cadherin 6
chr10_-_99235846 0.42 ENST00000370552.8
ENST00000370549.5
ENST00000628193.2
HPSE2
heparanase 2 (inactive)
chr3_+_178558700 0.39 ENST00000432997.5
ENST00000455865.5
KCNMB2
potassium calcium-activated channel subfamily M regulatory beta subunit 2
chr6_-_26043704 0.38 ENST00000615966.2
H2BC3
H2B clustered histone 3
chr4_-_109801978 0.35 ENST00000510800.1
ENST00000512148.5
ENST00000394634.7
ENST00000394635.8
ENST00000645635.1
CFI
ENSG00000285330.1
complement factor I
novel protein
chr20_-_18497218 0.33 ENST00000337227.9
RBBP9
RB binding protein 9, serine hydrolase
chr11_-_13496018 0.27 ENST00000529816.1
PTH
parathyroid hormone
chr22_-_40533808 0.26 ENST00000422851.1
ENST00000651694.1
ENST00000652095.2
MRTFA
myocardin related transcription factor A
chr12_-_52652207 0.23 ENST00000309680.4
KRT2
keratin 2
chr10_-_114144599 0.18 ENST00000428953.1
CCDC186
coiled-coil domain containing 186
chr5_+_31193739 0.12 ENST00000514738.5
CDH6
cadherin 6
chr10_-_62236112 0.11 ENST00000315289.6
RTKN2
rhotekin 2
chr1_-_109613070 0.09 ENST00000351050.8
GNAT2
G protein subunit alpha transducin 2
chr6_-_46735693 0.07 ENST00000537365.1
PLA2G7
phospholipase A2 group VII

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.5 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
5.9 29.3 GO:0007412 axon target recognition(GO:0007412)
4.7 14.0 GO:0030185 nitric oxide transport(GO:0030185)
4.5 13.6 GO:1904397 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
3.3 45.8 GO:0030050 vesicle transport along actin filament(GO:0030050)
2.2 13.5 GO:1903285 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
2.2 6.5 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
2.1 8.3 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
1.8 5.3 GO:0072275 metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.4 21.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
1.4 8.2 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
1.4 4.1 GO:0070408 carbamoyl phosphate metabolic process(GO:0070408) carbamoyl phosphate biosynthetic process(GO:0070409) cellular response to oleic acid(GO:0071400) response to ammonia(GO:1903717) cellular response to ammonia(GO:1903718)
1.1 5.6 GO:0035106 operant conditioning(GO:0035106)
1.1 39.8 GO:0008045 motor neuron axon guidance(GO:0008045)
1.1 4.3 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.9 24.4 GO:0071420 cellular response to histamine(GO:0071420)
0.7 1.4 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.6 9.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.6 3.9 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
0.5 3.8 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.5 6.1 GO:0008090 retrograde axonal transport(GO:0008090)
0.5 4.5 GO:0098535 de novo centriole assembly(GO:0098535)
0.5 2.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.5 2.9 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.5 7.7 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.4 5.8 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.4 7.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.4 3.3 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.4 2.3 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.4 1.9 GO:0016199 axon midline choice point recognition(GO:0016199)
0.4 3.3 GO:0051026 chiasma assembly(GO:0051026)
0.4 1.4 GO:0018032 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
0.3 1.6 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.3 2.8 GO:0015816 glycine transport(GO:0015816)
0.3 13.6 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 12.2 GO:0035640 exploration behavior(GO:0035640)
0.3 4.6 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 2.8 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.3 14.6 GO:0061718 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.2 2.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.2 1.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180)
0.2 0.7 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.2 2.1 GO:0060355 positive regulation of cell adhesion molecule production(GO:0060355)
0.2 2.3 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.2 3.4 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.2 4.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.2 12.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.2 8.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 0.6 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
0.2 3.2 GO:0006228 UTP biosynthetic process(GO:0006228)
0.1 9.8 GO:0021954 central nervous system neuron development(GO:0021954)
0.1 1.0 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.1 3.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 4.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.1 3.4 GO:0061512 protein localization to cilium(GO:0061512)
0.1 1.2 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.1 0.4 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 0.7 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 1.5 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)
0.1 6.3 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 1.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 4.1 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.1 0.9 GO:2001054 negative regulation of mesenchymal cell apoptotic process(GO:2001054)
0.1 10.8 GO:0007626 locomotory behavior(GO:0007626)
0.1 3.7 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 3.7 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.0 7.0 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 6.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.5 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.5 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.0 4.1 GO:0017156 calcium ion regulated exocytosis(GO:0017156)
0.0 0.5 GO:1904778 regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0 0.4 GO:0005513 detection of calcium ion(GO:0005513)
0.0 6.5 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.6 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 1.0 GO:0001764 neuron migration(GO:0001764)
0.0 0.9 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 4.9 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 1.0 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 0.2 GO:0045109 intermediate filament organization(GO:0045109)
0.0 0.1 GO:0046469 plasma lipoprotein particle oxidation(GO:0034441) platelet activating factor metabolic process(GO:0046469)
0.0 0.9 GO:0048813 dendrite morphogenesis(GO:0048813)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 15.7 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
1.8 14.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
1.5 4.5 GO:0098536 deuterosome(GO:0098536)
1.2 9.8 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.2 6.1 GO:0031673 H zone(GO:0031673)
0.9 3.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.8 3.3 GO:0000801 central element(GO:0000801)
0.6 6.5 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.6 24.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.6 8.2 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.5 29.3 GO:1904115 axon cytoplasm(GO:1904115)
0.5 2.9 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.5 5.8 GO:0016013 syntrophin complex(GO:0016013)
0.4 46.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.4 13.5 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 4.1 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.3 1.9 GO:1990761 growth cone lamellipodium(GO:1990761)
0.3 48.7 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 12.4 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.6 GO:0016342 catenin complex(GO:0016342)
0.1 2.4 GO:0097342 ripoptosome(GO:0097342)
0.1 0.6 GO:0044305 calyx of Held(GO:0044305)
0.1 2.0 GO:0043194 axon initial segment(GO:0043194)
0.1 10.6 GO:0031594 neuromuscular junction(GO:0031594)
0.1 13.8 GO:0005882 intermediate filament(GO:0005882)
0.1 2.8 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 4.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 17.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 5.3 GO:0005902 microvillus(GO:0005902)
0.1 2.3 GO:0008180 COP9 signalosome(GO:0008180)
0.1 1.4 GO:0005581 collagen trimer(GO:0005581)
0.0 17.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 3.3 GO:0043195 terminal bouton(GO:0043195)
0.0 3.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 2.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.5 GO:0031902 late endosome membrane(GO:0031902)
0.0 1.0 GO:0048786 presynaptic active zone(GO:0048786)
0.0 9.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 4.1 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.7 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.9 29.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
3.8 45.8 GO:0019911 structural constituent of myelin sheath(GO:0019911)
3.4 13.6 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
2.2 15.7 GO:0030492 hemoglobin binding(GO:0030492)
2.2 13.5 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
1.9 5.6 GO:0016497 substance K receptor activity(GO:0016497)
1.8 14.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
1.8 5.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.7 14.9 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.4 8.3 GO:0009378 four-way junction helicase activity(GO:0009378)
1.0 4.1 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
1.0 3.8 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.8 40.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.8 12.4 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.7 9.1 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.6 4.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.6 15.6 GO:0002162 dystroglycan binding(GO:0002162)
0.6 9.5 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.6 3.4 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.6 3.9 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.5 6.5 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.5 1.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.5 3.3 GO:0005499 vitamin D binding(GO:0005499)
0.5 9.6 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.4 2.4 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.4 31.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 1.4 GO:0004598 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.4 1.1 GO:0030305 heparanase activity(GO:0030305)
0.3 6.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 2.1 GO:0005534 galactose binding(GO:0005534)
0.3 3.6 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 3.7 GO:0031432 titin binding(GO:0031432)
0.2 8.2 GO:0001671 ATPase activator activity(GO:0001671)
0.2 4.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 1.9 GO:0051425 PTB domain binding(GO:0051425)
0.2 4.6 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.2 0.6 GO:0032093 SAM domain binding(GO:0032093)
0.2 9.1 GO:0050699 WW domain binding(GO:0050699)
0.2 1.2 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.2 0.5 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 0.5 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.1 1.6 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.1 2.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 21.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 3.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 3.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 0.4 GO:0004802 transketolase activity(GO:0004802)
0.1 4.2 GO:0030552 cAMP binding(GO:0030552)
0.1 2.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 2.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.0 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 6.3 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 19.5 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 8.8 GO:0002020 protease binding(GO:0002020)
0.0 0.7 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 10.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 7.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.2 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.9 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 16.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 2.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 42.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.6 48.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.6 23.5 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.5 12.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.5 11.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.3 3.9 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.3 20.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 5.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.2 7.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 9.8 PID LKB1 PATHWAY LKB1 signaling events
0.1 6.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 7.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 9.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.4 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 1.9 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.6 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.1 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 6.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.9 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 2.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 2.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 24.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 9.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 15.4 REACTOME AMYLOIDS Genes involved in Amyloids
0.3 12.4 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.3 21.2 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 6.5 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 14.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 44.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.4 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.2 4.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 25.6 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 8.2 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 3.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 9.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 7.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 2.4 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1 7.9 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 4.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 16.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 5.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 2.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 5.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 2.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 4.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.9 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.0 1.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.9 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 0.5 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0 0.6 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 1.0 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 2.1 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides