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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX6-2
Z-value: 0.90
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Transcription factors associated with NKX6-2
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 45.8 | GO:0030050 | vesicle transport along actin filament(GO:0030050) |
| 1.1 | 39.8 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 5.9 | 29.3 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.9 | 24.4 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 7.8 | 23.5 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 1.4 | 21.2 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 0.3 | 14.6 | GO:0061718 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 4.7 | 14.0 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 4.5 | 13.6 | GO:1904397 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.3 | 13.6 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 48.7 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.4 | 46.3 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.5 | 29.3 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.6 | 24.4 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 17.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 17.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 3.9 | 15.7 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 1.8 | 14.6 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.1 | 13.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.4 | 13.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.8 | 45.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.8 | 40.5 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.4 | 31.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.9 | 29.3 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.1 | 21.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 19.5 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.0 | 16.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.2 | 15.7 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.6 | 15.6 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.7 | 14.9 | GO:1904315 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 48.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.7 | 42.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.6 | 23.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 20.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.5 | 12.4 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 11.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 9.8 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 9.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.2 | 7.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 7.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 25.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.6 | 24.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 21.2 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 16.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.3 | 15.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.3 | 14.6 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 12.4 | REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE | Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| 0.1 | 9.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.3 | 9.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |