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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NKX6-3
Z-value: 0.30
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Transcription factors associated with NKX6-3
Network of associatons between targets according to the STRING database.
First level regulatory network of NKX6-3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr9_+_122370523 Show fit | 5.19 |
ENST00000643810.1
ENST00000540753.6 |
prostaglandin-endoperoxide synthase 1 |
|
| chr9_+_122371036 Show fit | 4.33 |
ENST00000619306.5
ENST00000426608.6 ENST00000223423.8 |
prostaglandin-endoperoxide synthase 1 |
|
| chr9_+_122371014 Show fit | 2.85 |
ENST00000362012.7
|
prostaglandin-endoperoxide synthase 1 |
|
| chr19_+_49513353 Show fit | 2.64 |
ENST00000596975.5
|
Fc fragment of IgG receptor and transporter |
|
| chr3_-_142029108 Show fit | 2.61 |
ENST00000497579.5
|
transcription factor Dp-2 |
|
| chr7_-_25228485 Show fit | 2.24 |
ENST00000222674.2
|
neuropeptide VF precursor |
|
| chr11_-_13495984 Show fit | 2.22 |
ENST00000282091.6
|
parathyroid hormone |
|
| chr20_-_35147285 Show fit | 2.00 |
ENST00000374491.3
ENST00000374492.8 |
ER degradation enhancing alpha-mannosidase like protein 2 |
|
| chr11_-_13496018 Show fit | 1.96 |
ENST00000529816.1
|
parathyroid hormone |
|
| chr20_+_45416551 Show fit | 1.73 |
ENST00000639292.1
|
phosphatidylinositol glycan anchor biosynthesis class T |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 12.4 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 1.0 | 4.2 | GO:1900158 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.1 | 3.4 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.9 | 2.6 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 0.2 | 2.2 | GO:0032277 | negative regulation of gonadotropin secretion(GO:0032277) |
| 0.7 | 2.0 | GO:0036510 | trimming of terminal mannose on C branch(GO:0036510) |
| 0.2 | 1.7 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.2 | 1.5 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.1 | 1.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 1.0 | GO:2000389 | regulation of neutrophil extravasation(GO:2000389) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 3.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.0 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.4 | 1.7 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 1.0 | GO:0035580 | specific granule lumen(GO:0035580) |
| 0.0 | 0.9 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.7 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.0 | 0.5 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.1 | 0.4 | GO:0033186 | CAF-1 complex(GO:0033186) |
| 0.0 | 0.4 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 12.4 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.2 | 4.2 | GO:0048018 | receptor agonist activity(GO:0048018) |
| 0.7 | 2.6 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.2 | 2.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.4 | 1.7 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.3 | 1.5 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051) |
| 0.1 | 1.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.0 | 0.9 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.8 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 0.2 | 0.7 | GO:0008511 | sodium:potassium:chloride symporter activity(GO:0008511) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.7 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 1.5 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 0.7 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.4 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.0 | 4.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.0 | REACTOME CALNEXIN CALRETICULIN CYCLE | Genes involved in Calnexin/calreticulin cycle |
| 0.1 | 1.7 | REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS | Genes involved in Post-translational modification: synthesis of GPI-anchored proteins |
| 0.0 | 1.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.0 | 0.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.7 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.0 | 0.5 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.4 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |