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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NKX6-3

Z-value: 0.30

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Transcription factors associated with NKX6-3

Gene Symbol Gene ID Gene Info
NKX6-3
ENSG00000165066.13 NKX6-3

Activity profile of NKX6-3 motif

Sorted Z-values of NKX6-3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NKX6-3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr9_+_122370523 5.19 ENST00000643810.1
ENST00000540753.6
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371036 4.33 ENST00000619306.5
ENST00000426608.6
ENST00000223423.8
PTGS1
prostaglandin-endoperoxide synthase 1
chr9_+_122371014 2.85 ENST00000362012.7
PTGS1
prostaglandin-endoperoxide synthase 1
chr19_+_49513353 2.64 ENST00000596975.5
FCGRT
Fc fragment of IgG receptor and transporter
chr3_-_142029108 2.61 ENST00000497579.5
TFDP2
transcription factor Dp-2
chr7_-_25228485 2.24 ENST00000222674.2
NPVF
neuropeptide VF precursor
chr11_-_13495984 2.22 ENST00000282091.6
PTH
parathyroid hormone
chr20_-_35147285 2.00 ENST00000374491.3
ENST00000374492.8
EDEM2
ER degradation enhancing alpha-mannosidase like protein 2
chr11_-_13496018 1.96 ENST00000529816.1
PTH
parathyroid hormone
chr20_+_45416551 1.73 ENST00000639292.1
PIGT
phosphatidylinositol glycan anchor biosynthesis class T
chr5_-_143400716 1.55 ENST00000424646.6
ENST00000652686.1
NR3C1
nuclear receptor subfamily 3 group C member 1
chr14_-_50561119 1.50 ENST00000555216.5
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr3_+_138621225 1.34 ENST00000479848.1
FAIM
Fas apoptotic inhibitory molecule
chr13_+_53028806 1.01 ENST00000219022.3
OLFM4
olfactomedin 4
chr17_-_10469558 0.94 ENST00000255381.2
MYH4
myosin heavy chain 4
chr3_-_142000353 0.82 ENST00000499676.5
TFDP2
transcription factor Dp-2
chr5_-_58999885 0.82 ENST00000317118.12
PDE4D
phosphodiesterase 4D
chr3_+_138621207 0.82 ENST00000464668.5
FAIM
Fas apoptotic inhibitory molecule
chr1_-_113871665 0.77 ENST00000528414.5
ENST00000460620.5
ENST00000359785.10
ENST00000420377.6
ENST00000525799.1
ENST00000538253.5
PTPN22
protein tyrosine phosphatase non-receptor type 22
chr5_-_140346596 0.74 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr15_+_48191648 0.70 ENST00000646012.1
ENST00000561127.5
ENST00000647546.1
ENST00000559641.5
ENST00000417307.3
SLC12A1
CTXN2
solute carrier family 12 member 1
cortexin 2
chr6_+_113857333 0.54 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr19_+_4402615 0.42 ENST00000301280.10
CHAF1A
chromatin assembly factor 1 subunit A
chr3_+_136930469 0.42 ENST00000469404.1
ENST00000467911.1
NCK1
NCK adaptor protein 1
chr15_+_92900189 0.40 ENST00000626874.2
ENST00000627622.1
ENST00000629346.2
ENST00000628375.2
ENST00000420239.7
ENST00000394196.9
CHD2
chromodomain helicase DNA binding protein 2
chr12_-_52367478 0.35 ENST00000257901.7
KRT85
keratin 85
chrX_+_108045050 0.32 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr4_-_122621011 0.32 ENST00000611104.2
ENST00000648588.1
IL21
interleukin 21
chr17_-_66229380 0.29 ENST00000205948.11
APOH
apolipoprotein H
chrX_+_108044967 0.26 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr3_-_165078480 0.21 ENST00000264382.8
SI
sucrase-isomaltase
chr20_-_7940444 0.18 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr16_+_86566821 0.17 ENST00000649859.1
FOXC2
forkhead box C2
chr7_+_138460238 0.17 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr16_-_67483541 0.12 ENST00000290953.3
AGRP
agouti related neuropeptide
chrX_+_43656289 0.06 ENST00000338702.4
MAOA
monoamine oxidase A
chr8_+_76681208 0.03 ENST00000651372.2
ZFHX4
zinc finger homeobox 4
chr2_+_233917371 0.01 ENST00000324695.9
ENST00000433712.6
TRPM8
transient receptor potential cation channel subfamily M member 8
chrX_+_47836877 0.01 ENST00000338637.13
ENST00000376954.6
ZNF81
zinc finger protein 81

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.2 GO:1900158 positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.9 2.6 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.7 2.0 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.6 12.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 1.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 2.2 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.2 1.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.2 0.8 GO:1902523 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.1 0.4 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
0.1 0.7 GO:0051541 elastin metabolic process(GO:0051541)
0.1 0.8 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1 1.0 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 3.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.1 1.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.3 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 0.2 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0 0.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.5 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 0.9 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.1 12.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 0.4 GO:0033186 CAF-1 complex(GO:0033186)
0.1 2.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 0.5 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.9 GO:0032982 myosin filament(GO:0032982)
0.0 0.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 3.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 1.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 12.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.7 2.6 GO:0019770 IgG receptor activity(GO:0019770)
0.4 1.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.3 1.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.2 2.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.2 0.7 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)
0.2 4.2 GO:0048018 receptor agonist activity(GO:0048018)
0.1 1.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.4 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
0.1 0.2 GO:0052852 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.0 0.3 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.0 0.2 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.0 0.4 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.8 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.9 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.2 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.4 PID E2F PATHWAY E2F transcription factor network
0.0 1.7 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 1.5 PID TNF PATHWAY TNF receptor signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 12.4 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.1 2.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 1.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 4.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events