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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR1D1
Z-value: 0.78
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Transcription factors associated with NR1D1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1D1 | hg38_v1_chr17_-_40100569_40100597 | 0.49 | 1.9e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1D1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 45.1 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 2.3 | 20.3 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 2.1 | 18.5 | GO:0098814 | spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814) |
| 0.1 | 18.4 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 1.4 | 16.9 | GO:1905098 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.1 | 12.2 | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178) |
| 0.7 | 10.3 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.2 | 9.5 | GO:0021762 | substantia nigra development(GO:0021762) |
| 2.4 | 9.4 | GO:0035054 | embryonic heart tube anterior/posterior pattern specification(GO:0035054) |
| 0.1 | 9.4 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.2 | GO:0045202 | synapse(GO:0045202) |
| 0.1 | 33.9 | GO:0005874 | microtubule(GO:0005874) |
| 0.3 | 18.5 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.9 | 14.2 | GO:0097433 | dense body(GO:0097433) |
| 0.3 | 11.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 9.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 9.2 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.3 | 6.2 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 1.2 | 6.1 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 5.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.5 | 45.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.1 | 23.4 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.5 | 20.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 18.4 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 15.7 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.4 | 14.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.3 | 9.4 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 9.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.2 | 8.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 2.3 | 7.0 | GO:0004421 | hydroxymethylglutaryl-CoA synthase activity(GO:0004421) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 18.4 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.8 | 16.9 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 9.4 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 7.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 6.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.2 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.0 | 6.1 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 3.5 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 3.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 3.3 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 45.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 11.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 9.4 | REACTOME SIGNALING BY PDGF | Genes involved in Signaling by PDGF |
| 0.3 | 8.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 7.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 6.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.2 | 6.1 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.1 | 5.7 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 5.1 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 4.1 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |