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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR1H2
Z-value: 0.61
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Transcription factors associated with NR1H2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H2 | hg38_v1_chr19_+_50376447_50376518 | -0.18 | 8.7e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 13.9 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 2.6 | 10.3 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.6 | 8.6 | GO:2000680 | rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680) |
| 0.1 | 8.6 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 7.1 | GO:0021915 | neural tube development(GO:0021915) |
| 2.3 | 7.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.4 | 6.0 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.9 | 5.7 | GO:1901523 | leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569) |
| 0.7 | 5.6 | GO:0006729 | tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146) |
| 0.1 | 5.1 | GO:0005980 | glycogen catabolic process(GO:0005980) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 19.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.7 | 8.6 | GO:0097487 | multivesicular body, internal vesicle(GO:0097487) |
| 0.0 | 8.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.2 | 7.1 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.1 | 6.0 | GO:0030673 | axolemma(GO:0030673) |
| 0.5 | 5.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.1 | 4.3 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 4.2 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 3.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 3.1 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.9 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.3 | 10.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 9.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.4 | 6.0 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 6.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 1.4 | 5.6 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.5 | 5.1 | GO:0004689 | phosphorylase kinase activity(GO:0004689) |
| 0.0 | 4.3 | GO:0005518 | collagen binding(GO:0005518) |
| 1.4 | 4.2 | GO:0097258 | tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259) |
| 0.8 | 4.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 8.6 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 4.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 4.0 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 3.0 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.0 | 3.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.7 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.0 | 2.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 2.0 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 2.0 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 18.1 | REACTOME FATTY ACYL COA BIOSYNTHESIS | Genes involved in Fatty Acyl-CoA Biosynthesis |
| 0.1 | 11.1 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 9.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 8.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 8.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 7.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.0 | 5.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 5.1 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.0 | 4.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 2.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |