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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR1H4
Z-value: 1.20
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Transcription factors associated with NR1H4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR1H4 | hg38_v1_chr12_+_100473951_100473972, hg38_v1_chr12_+_100473708_100473874 | 0.35 | 1.7e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR1H4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 86.5 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 2.7 | 56.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 3.3 | 35.8 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 4.3 | 34.4 | GO:0061709 | reticulophagy(GO:0061709) |
| 1.3 | 25.5 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 2.5 | 22.8 | GO:0060125 | negative regulation of growth hormone secretion(GO:0060125) |
| 0.6 | 20.8 | GO:0015695 | organic cation transport(GO:0015695) |
| 0.8 | 19.5 | GO:1900037 | regulation of cellular response to hypoxia(GO:1900037) |
| 3.7 | 18.5 | GO:0032792 | negative regulation of CREB transcription factor activity(GO:0032792) |
| 0.2 | 16.3 | GO:0051865 | protein autoubiquitination(GO:0051865) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 72.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 57.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.0 | 47.6 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.5 | 34.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 1.8 | 25.5 | GO:0035859 | Seh1-associated complex(GO:0035859) |
| 0.4 | 25.5 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 24.9 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 21.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 1.0 | 19.2 | GO:0010369 | chromocenter(GO:0010369) |
| 6.2 | 18.5 | GO:1990622 | CHOP-ATF3 complex(GO:1990622) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 56.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.2 | 35.3 | GO:0071949 | FAD binding(GO:0071949) |
| 2.0 | 25.5 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.3 | 24.7 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 23.4 | GO:0030695 | GTPase regulator activity(GO:0030695) |
| 0.7 | 22.8 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.6 | 20.8 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 1.1 | 19.5 | GO:1990380 | Lys48-specific deubiquitinase activity(GO:1990380) |
| 1.2 | 18.5 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 17.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 105.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.6 | 25.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.3 | 22.8 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.2 | 17.5 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.8 | 15.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.3 | 13.7 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.3 | 13.1 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.3 | 12.6 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.2 | 12.2 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.2 | 11.9 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 47.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 1.3 | 18.5 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.4 | 15.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 15.4 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.6 | 13.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 13.0 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 11.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 10.5 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.4 | 10.3 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.1 | 9.8 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |