ISMARA results: NR1I2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR1I2

Z-value: 1.21

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Transcription factors associated with NR1I2

Gene Symbol	Gene ID	Gene Info
NR1I2 Ensembl NCBI GeneCards UniProt	ENSG00000144852.20	NR1I2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR1I2	hg38_v1_chr3_+_119782094_119782114	0.25	1.4e-04	Click!

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_91182652 Show fit	49.20	ENST00000552145.5 ENST00000546745.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr12_-_91182784 Show fit	18.67	ENST00000547568.6 ENST00000052754.10 ENST00000552962.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr19_+_42313374 Show fit	18.52	ENST00000598766.1 ENST00000673187.1	TMEM145 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 145
chrX_-_19965142 Show fit	18.22	ENST00000340625.3	BCLAF3 Ensembl NCBI GeneCards UniProt Show fit	BCLAF1 and THRAP3 family member 3
chr11_+_62671664 Show fit	14.35	ENST00000377953.4	UQCC3 Ensembl NCBI GeneCards UniProt Show fit	ubiquinol-cytochrome c reductase complex assembly factor 3
chr1_-_173824107 Show fit	13.81	ENST00000345664.10 ENST00000367710.7	CENPL Ensembl NCBI GeneCards UniProt Show fit	centromere protein L
chr16_-_4242068 Show fit	13.79	ENST00000399609.7	SRL Ensembl NCBI GeneCards UniProt Show fit	sarcalumenin
chr9_-_4741176 Show fit	13.23	ENST00000381809.8	AK3 Ensembl NCBI GeneCards UniProt Show fit	adenylate kinase 3
chr16_-_15856994 Show fit	12.64	ENST00000576790.7 ENST00000396324.7 ENST00000300036.6 ENST00000452625.7	MYH11 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 11
chr8_-_81483226 Show fit	12.40	ENST00000256104.5	FABP4 Ensembl NCBI GeneCards UniProt Show fit	fatty acid binding protein 4

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	78.4	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.9	31.5	GO:0061641	chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3	28.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4	27.7	GO:0003254	regulation of membrane depolarization(GO:0003254)
0.9	26.1	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
1.5	25.3	GO:0007021	tubulin complex assembly(GO:0007021)
0.1	18.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.5	17.4	GO:0071711	basement membrane organization(GO:0071711)
3.0	14.9	GO:1901202	negative regulation of extracellular matrix assembly(GO:1901202)
0.3	14.3	GO:0032728	positive regulation of interferon-beta production(GO:0032728)

Showing 1 to 10 of 212 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.2	67.9	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0	50.3	GO:0005615	extracellular space(GO:0005615)
0.1	36.9	GO:0005925	cell-substrate adherens junction(GO:0005924) focal adhesion(GO:0005925)
1.8	28.7	GO:0097512	cardiac myofibril(GO:0097512)
0.1	22.8	GO:0000775	chromosome, centromeric region(GO:0000775)
0.2	21.6	GO:0005811	lipid particle(GO:0005811)
0.0	19.7	GO:0005667	transcription factor complex(GO:0005667)
0.1	16.3	GO:0072562	blood microparticle(GO:0072562)
0.5	16.1	GO:0031527	filopodium membrane(GO:0031527)
0.3	13.9	GO:0016592	mediator complex(GO:0016592)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	69.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	29.5	GO:0046982	protein heterodimerization activity(GO:0046982)
0.1	29.1	GO:0001159	core promoter proximal region DNA binding(GO:0001159)
0.4	28.4	GO:0005518	collagen binding(GO:0005518)
0.8	24.5	GO:0005212	structural constituent of eye lens(GO:0005212)
0.1	20.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.7	17.3	GO:0005549	odorant binding(GO:0005549)
0.1	17.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	16.7	GO:0003714	transcription corepressor activity(GO:0003714)
0.4	14.4	GO:0001972	retinoic acid binding(GO:0001972)

Showing 1 to 10 of 151 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	64.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	37.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	27.7	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	26.1	PID INTEGRIN1 PATHWAY	Beta1 integrin cell surface interactions
0.2	23.8	PID AP1 PATHWAY	AP-1 transcription factor network
0.2	16.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.5	14.9	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.3	13.5	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.1	13.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.1	9.9	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	67.9	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.3	28.3	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.2	26.2	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.2	23.1	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.2	21.8	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.2	20.5	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	20.3	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	19.5	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.5	13.8	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	13.6	REACTOME POTASSIUM CHANNELS	Genes involved in Potassium Channels

Showing 1 to 10 of 66 entries

Results for NR1I2

Z-value: 1.21

Motif logo

Transcription factors associated with NR1I2

Activity-expression correlation:

Activity profile of NR1I2 motif

Sorted Z-values of NR1I2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1I2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: