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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR2C1

Z-value: 0.61

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Transcription factors associated with NR2C1

Gene Symbol Gene ID Gene Info
NR2C1
ENSG00000120798.17 NR2C1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2C1hg38_v1_chr12_-_95073490_950735740.243.4e-04Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_38561530 13.62 ENST00000378482.7
ENST00000286824.6
TSPAN7
tetraspanin 7
chr1_+_160127672 9.26 ENST00000447527.1
ATP1A2
ATPase Na+/K+ transporting subunit alpha 2
chr17_-_15999689 8.12 ENST00000399277.6
ZSWIM7
zinc finger SWIM-type containing 7
chr3_-_58627596 7.76 ENST00000474531.5
ENST00000465970.1
FAM107A
family with sequence similarity 107 member A
chr12_+_48106094 6.97 ENST00000546755.5
ENST00000549366.5
ENST00000642730.1
ENST00000552792.5
PFKM
phosphofructokinase, muscle
chr3_-_58627567 6.63 ENST00000649301.1
FAM107A
family with sequence similarity 107 member A
chr22_+_39349925 5.86 ENST00000318801.8
ENST00000216155.11
ENST00000406293.7
ENST00000328933.10
SYNGR1
synaptogyrin 1
chr9_+_137618986 4.84 ENST00000462484.5
ENST00000630754.2
ENST00000460843.6
ENST00000626216.2
ENST00000629335.2
EHMT1
euchromatic histone lysine methyltransferase 1
chr3_-_50567646 4.71 ENST00000426034.5
ENST00000441239.5
C3orf18
chromosome 3 open reading frame 18
chr18_+_56651335 4.52 ENST00000589935.1
ENST00000254442.8
ENST00000357574.7
WDR7
WD repeat domain 7
chr14_-_21024092 4.48 ENST00000554398.5
NDRG2
NDRG family member 2
chr7_+_121873152 4.44 ENST00000650826.1
ENST00000650728.1
ENST00000393386.7
ENST00000651390.1
ENST00000651842.1
ENST00000650681.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr18_+_56651385 4.38 ENST00000615645.4
WDR7
WD repeat domain 7
chr14_-_21023954 4.33 ENST00000554094.5
NDRG2
NDRG family member 2
chr11_-_134411854 4.31 ENST00000392580.5
B3GAT1
beta-1,3-glucuronyltransferase 1
chr3_+_42856021 4.07 ENST00000493193.1
ACKR2
atypical chemokine receptor 2
chr7_+_121873089 4.05 ENST00000651065.1
PTPRZ1
protein tyrosine phosphatase receptor type Z1
chr16_-_4242068 3.93 ENST00000399609.7
SRL
sarcalumenin
chr6_+_30626842 3.72 ENST00000318999.11
ENST00000376485.8
ENST00000330083.6
ENST00000319027.9
ENST00000376483.8
ENST00000329992.12
ATAT1
alpha tubulin acetyltransferase 1
chr17_-_41586887 3.54 ENST00000167586.7
KRT14
keratin 14
chr3_-_50567711 3.45 ENST00000357203.8
C3orf18
chromosome 3 open reading frame 18
chr13_+_21140514 3.27 ENST00000382533.8
ENST00000621421.4
SAP18
Sin3A associated protein 18
chr2_-_201451446 3.24 ENST00000332624.8
ENST00000430254.1
TRAK2
trafficking kinesin protein 2
chr3_+_101827982 3.10 ENST00000461724.5
ENST00000483180.5
ENST00000394054.6
NFKBIZ
NFKB inhibitor zeta
chr19_-_45639104 2.91 ENST00000586770.5
ENST00000591721.5
ENST00000245925.8
ENST00000590043.5
ENST00000589876.5
EML2
EMAP like 2
chr19_-_38315919 2.89 ENST00000591755.5
ENST00000337679.12
ENST00000339413.11
YIF1B
Yip1 interacting factor homolog B, membrane trafficking protein
chr5_-_42811884 2.73 ENST00000514985.6
ENST00000511224.5
ENST00000507920.5
ENST00000510965.1
SELENOP
selenoprotein P
chr3_+_184337591 2.70 ENST00000383847.7
FAM131A
family with sequence similarity 131 member A
chr12_-_42237727 2.67 ENST00000548917.1
YAF2
YY1 associated factor 2
chr3_+_159839847 2.64 ENST00000445224.6
SCHIP1
schwannomin interacting protein 1
chr3_-_33659097 2.61 ENST00000461133.8
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr22_+_41381923 2.60 ENST00000266304.9
TEF
TEF transcription factor, PAR bZIP family member
chr13_+_21140572 2.59 ENST00000607003.5
ENST00000492245.5
SAP18
Sin3A associated protein 18
chr4_+_158672266 2.57 ENST00000684622.1
ENST00000683483.1
ENST00000684641.1
ENST00000682456.1
ENST00000684627.1
ENST00000511912.6
ENST00000684505.1
ENST00000683305.1
ENST00000684036.1
ENST00000683751.1
ENST00000684129.1
ENST00000307738.5
ETFDH
electron transfer flavoprotein dehydrogenase
chr1_+_43946905 2.56 ENST00000372343.8
IPO13
importin 13
chr16_+_30699155 2.55 ENST00000262518.9
SRCAP
Snf2 related CREBBP activator protein
chr3_-_33659441 2.53 ENST00000650653.1
ENST00000480013.6
CLASP2
cytoplasmic linker associated protein 2
chr3_+_155083523 2.47 ENST00000680057.1
MME
membrane metalloendopeptidase
chr6_+_31547560 2.44 ENST00000376148.9
ENST00000376145.8
NFKBIL1
NFKB inhibitor like 1
chr11_+_10450627 2.35 ENST00000396554.7
ENST00000524866.5
AMPD3
adenosine monophosphate deaminase 3
chr22_-_50582785 2.30 ENST00000406938.3
CHKB
choline kinase beta
chr4_+_158672237 2.29 ENST00000682734.1
ETFDH
electron transfer flavoprotein dehydrogenase
chr14_-_72894091 2.29 ENST00000556509.6
DPF3
double PHD fingers 3
chr11_+_60924452 2.23 ENST00000453848.7
ENST00000544065.5
ENST00000005286.8
TMEM132A
transmembrane protein 132A
chr21_-_31558977 2.17 ENST00000286827.7
ENST00000541036.5
TIAM1
TIAM Rac1 associated GEF 1
chr3_+_155083889 2.17 ENST00000680282.1
MME
membrane metalloendopeptidase
chr10_-_121596117 2.13 ENST00000351936.11
FGFR2
fibroblast growth factor receptor 2
chr1_-_30908681 2.12 ENST00000339394.7
SDC3
syndecan 3
chr19_+_39125769 1.99 ENST00000602004.1
ENST00000599470.5
ENST00000321944.8
ENST00000593480.5
ENST00000358301.7
ENST00000593690.5
ENST00000599386.5
PAK4
p21 (RAC1) activated kinase 4
chrX_-_43882411 1.96 ENST00000378069.5
MAOB
monoamine oxidase B
chr11_+_10450289 1.96 ENST00000444303.6
AMPD3
adenosine monophosphate deaminase 3
chr7_+_39623886 1.94 ENST00000436179.1
RALA
RAS like proto-oncogene A
chr1_+_110210272 1.88 ENST00000438661.3
KCNC4
potassium voltage-gated channel subfamily C member 4
chr3_+_150546765 1.88 ENST00000406576.7
ENST00000460851.6
ENST00000482093.5
ENST00000273435.9
EIF2A
eukaryotic translation initiation factor 2A
chr3_+_37243333 1.87 ENST00000431105.1
GOLGA4
golgin A4
chr14_-_77320855 1.84 ENST00000556394.2
ENST00000261534.9
POMT2
protein O-mannosyltransferase 2
chr20_-_45857196 1.83 ENST00000457981.5
ENST00000426915.1
ENST00000217455.9
ACOT8
acyl-CoA thioesterase 8
chr19_-_35812838 1.82 ENST00000653904.2
PRODH2
proline dehydrogenase 2
chr22_-_29388530 1.81 ENST00000357586.7
ENST00000432560.6
ENST00000405198.6
ENST00000317368.11
AP1B1
adaptor related protein complex 1 subunit beta 1
chr6_-_159727324 1.79 ENST00000401980.3
ENST00000545162.5
SOD2
superoxide dismutase 2
chr1_-_229434086 1.77 ENST00000366684.7
ENST00000684723.1
ENST00000366683.4
ACTA1
actin alpha 1, skeletal muscle
chr19_-_40750302 1.75 ENST00000598485.6
ENST00000378313.7
ENST00000470681.5
C19orf54
chromosome 19 open reading frame 54
chr13_-_33185994 1.68 ENST00000255486.8
STARD13
StAR related lipid transfer domain containing 13
chr2_-_201071579 1.65 ENST00000453765.5
ENST00000452799.5
ENST00000446678.5
ENST00000418596.7
ENST00000681958.1
FAM126B
family with sequence similarity 126 member B
chr19_-_48868590 1.63 ENST00000263265.11
PLEKHA4
pleckstrin homology domain containing A4
chr17_+_39665340 1.63 ENST00000578283.1
ENST00000309889.3
TCAP
titin-cap
chr19_-_48868454 1.60 ENST00000355496.9
PLEKHA4
pleckstrin homology domain containing A4
chr14_-_77320813 1.58 ENST00000682467.1
POMT2
protein O-mannosyltransferase 2
chr17_-_37745018 1.56 ENST00000613727.4
ENST00000614313.4
ENST00000617811.5
ENST00000621123.4
HNF1B
HNF1 homeobox B
chr3_+_184186023 1.55 ENST00000429586.6
ENST00000292808.5
ABCF3
ATP binding cassette subfamily F member 3
chr19_-_50968775 1.54 ENST00000391808.5
KLK6
kallikrein related peptidase 6
chr12_-_89656093 1.47 ENST00000359142.7
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr12_-_89656051 1.44 ENST00000261173.6
ATP2B1
ATPase plasma membrane Ca2+ transporting 1
chr22_-_38455199 1.43 ENST00000303592.3
KCNJ4
potassium inwardly rectifying channel subfamily J member 4
chr14_-_77320741 1.42 ENST00000682795.1
ENST00000682247.1
POMT2
protein O-mannosyltransferase 2
chr2_+_218568809 1.42 ENST00000273064.11
CNOT9
CCR4-NOT transcription complex subunit 9
chr15_+_45129933 1.40 ENST00000321429.8
ENST00000389037.7
ENST00000558322.5
DUOX1
dual oxidase 1
chr10_-_102056116 1.39 ENST00000370033.9
ENST00000311122.5
ARMH3
armadillo like helical domain containing 3
chr16_+_83899079 1.37 ENST00000262430.6
MLYCD
malonyl-CoA decarboxylase
chr12_-_42238203 1.31 ENST00000327791.8
ENST00000534854.7
YAF2
YY1 associated factor 2
chr1_+_22052627 1.27 ENST00000400259.5
ENST00000344548.7
ENST00000315554.13
ENST00000656825.1
ENST00000651171.1
ENST00000652582.1
ENST00000667384.1
CDC42
cell division cycle 42
chr12_+_6385119 1.27 ENST00000541102.1
LTBR
lymphotoxin beta receptor
chr22_+_24423597 1.25 ENST00000424232.5
ENST00000611543.4
ENST00000486108.1
ADORA2A
adenosine A2a receptor
chr22_+_46762617 1.24 ENST00000380995.5
ENST00000337137.9
ENST00000407381.7
TBC1D22A
TBC1 domain family member 22A
chr3_+_113747022 1.17 ENST00000273398.8
ENST00000496747.5
ENST00000475322.1
ATP6V1A
ATPase H+ transporting V1 subunit A
chr11_+_22668101 1.12 ENST00000630668.2
ENST00000278187.7
GAS2
growth arrest specific 2
chr2_+_33476640 1.08 ENST00000425210.5
ENST00000444784.5
ENST00000423159.5
ENST00000403687.8
RASGRP3
RAS guanyl releasing protein 3
chr7_-_38909174 1.07 ENST00000395969.6
ENST00000310301.9
ENST00000414632.5
VPS41
VPS41 subunit of HOPS complex
chr9_-_33402449 1.03 ENST00000377425.8
AQP7
aquaporin 7
chr2_+_74530018 1.00 ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr11_-_45917867 1.00 ENST00000378750.10
PEX16
peroxisomal biogenesis factor 16
chr2_-_162242998 0.98 ENST00000627638.2
ENST00000447386.5
FAP
fibroblast activation protein alpha
chr6_-_142147122 0.97 ENST00000258042.2
NMBR
neuromedin B receptor
chr19_-_4066892 0.93 ENST00000322357.9
ZBTB7A
zinc finger and BTB domain containing 7A
chr12_+_51907478 0.93 ENST00000388922.9
ACVRL1
activin A receptor like type 1
chr2_-_162243375 0.91 ENST00000188790.9
ENST00000443424.5
FAP
fibroblast activation protein alpha
chr22_-_31140494 0.90 ENST00000215885.4
PLA2G3
phospholipase A2 group III
chr12_-_63151192 0.85 ENST00000299178.4
AVPR1A
arginine vasopressin receptor 1A
chr4_-_84499281 0.84 ENST00000295886.5
NKX6-1
NK6 homeobox 1
chr17_+_76000906 0.82 ENST00000448471.2
CDK3
cyclin dependent kinase 3
chr21_+_44012296 0.81 ENST00000291574.9
ENST00000380221.7
TRAPPC10
trafficking protein particle complex 10
chr12_+_109139397 0.80 ENST00000377854.9
ENST00000377848.7
ACACB
acetyl-CoA carboxylase beta
chr22_+_46762677 0.80 ENST00000355704.7
TBC1D22A
TBC1 domain family member 22A
chrX_-_112840815 0.78 ENST00000304758.5
ENST00000371959.9
AMOT
angiomotin
chr2_+_218568558 0.74 ENST00000627282.2
ENST00000542068.5
CNOT9
CCR4-NOT transcription complex subunit 9
chr12_-_22334683 0.72 ENST00000404299.3
ENST00000396037.9
ST8SIA1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
chr19_+_10086305 0.61 ENST00000253110.16
ENST00000591813.5
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chrX_-_153944621 0.61 ENST00000393700.8
RENBP
renin binding protein
chr15_-_82806054 0.59 ENST00000541889.1
ENST00000334574.12
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr12_-_6556034 0.57 ENST00000619571.5
ENST00000336604.8
ENST00000396840.6
ENST00000356896.8
IFFO1
intermediate filament family orphan 1
chr2_-_38076076 0.54 ENST00000614273.1
ENST00000610745.5
ENST00000490576.1
CYP1B1
cytochrome P450 family 1 subfamily B member 1
chr6_-_159726871 0.54 ENST00000535561.5
SOD2
superoxide dismutase 2
chr9_-_33402551 0.54 ENST00000297988.6
ENST00000624075.3
ENST00000625032.1
ENST00000625109.3
AQP7
aquaporin 7
chr1_-_19923617 0.53 ENST00000375116.3
PLA2G2E
phospholipase A2 group IIE
chr4_-_110623051 0.52 ENST00000557119.2
ENST00000644743.1
PITX2
paired like homeodomain 2
chr20_+_38962299 0.52 ENST00000373325.6
ENST00000373323.8
ENST00000252011.8
ENST00000615559.1
DHX35
ENSG00000277581.1
DEAH-box helicase 35
novel transcript, sense intronic to DHX35
chr17_+_14069489 0.44 ENST00000429152.6
ENST00000261643.8
COX10
cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
chr11_-_26722051 0.43 ENST00000396005.8
SLC5A12
solute carrier family 5 member 12
chr1_-_145707387 0.39 ENST00000451928.6
PDZK1
PDZ domain containing 1
chr3_-_116444983 0.39 ENST00000333617.8
LSAMP
limbic system associated membrane protein
chr11_+_64306227 0.36 ENST00000405666.5
ENST00000468670.2
ESRRA
estrogen related receptor alpha
chr13_+_100089015 0.35 ENST00000376286.8
ENST00000376279.7
ENST00000376285.6
PCCA
propionyl-CoA carboxylase subunit alpha
chr12_-_118372883 0.34 ENST00000542532.5
ENST00000392533.8
TAOK3
TAO kinase 3
chr1_-_145707345 0.32 ENST00000417171.6
PDZK1
PDZ domain containing 1
chr17_+_76001338 0.30 ENST00000425876.6
CDK3
cyclin dependent kinase 3
chr21_-_14546351 0.29 ENST00000619120.4
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr8_-_92103217 0.28 ENST00000615601.4
ENST00000523629.5
RUNX1T1
RUNX1 partner transcriptional co-repressor 1
chr3_+_179347686 0.25 ENST00000471841.6
MFN1
mitofusin 1
chr19_+_10086787 0.23 ENST00000590378.5
ENST00000397881.7
SHFL
shiftless antiviral inhibitor of ribosomal frameshifting
chr7_+_121328991 0.23 ENST00000222462.3
WNT16
Wnt family member 16
chr14_+_77320996 0.23 ENST00000361389.8
ENST00000554279.5
ENST00000557639.5
ENST00000349555.7
ENST00000216465.10
ENST00000556627.5
ENST00000557053.5
GSTZ1
glutathione S-transferase zeta 1
chr1_-_119896489 0.22 ENST00000369400.2
ADAM30
ADAM metallopeptidase domain 30
chr6_-_31170620 0.20 ENST00000638788.1
ENST00000259915.13
POU5F1
POU class 5 homeobox 1
chr2_+_74529923 0.19 ENST00000258080.8
ENST00000352222.7
HTRA2
HtrA serine peptidase 2
chr10_+_26697653 0.19 ENST00000376215.10
PDSS1
decaprenyl diphosphate synthase subunit 1
chr3_-_116445458 0.19 ENST00000490035.7
LSAMP
limbic system associated membrane protein
chr1_-_27366917 0.19 ENST00000357582.3
MAP3K6
mitogen-activated protein kinase kinase kinase 6
chr5_+_171419635 0.18 ENST00000274625.6
FGF18
fibroblast growth factor 18
chr17_+_15999815 0.15 ENST00000261647.10
TTC19
tetratricopeptide repeat domain 19
chr11_-_45918014 0.13 ENST00000525192.5
PEX16
peroxisomal biogenesis factor 16
chr21_-_14546297 0.13 ENST00000400566.6
ENST00000400564.5
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_43596388 0.11 ENST00000391965.6
ENST00000525771.1
ZNF576
zinc finger protein 576
chrX_+_22136552 0.10 ENST00000682888.1
ENST00000684356.1
PHEX
phosphate regulating endopeptidase homolog X-linked
chr2_+_119366924 0.10 ENST00000535757.5
ENST00000535617.5
ENST00000627093.2
ENST00000355857.8
ENST00000409094.5
ENST00000542275.5
ENST00000311521.8
DBI
diazepam binding inhibitor, acyl-CoA binding protein
chr19_+_11239602 0.09 ENST00000252453.12
ANGPTL8
angiopoietin like 8
chr1_-_101025763 0.07 ENST00000342173.11
ENST00000488176.1
ENST00000370109.8
DPH5
diphthamide biosynthesis 5
chrX_+_16786421 0.05 ENST00000398155.4
ENST00000380122.10
TXLNG
taxilin gamma
chr11_-_45917823 0.00 ENST00000533151.5
ENST00000241041.7
PEX16
peroxisomal biogenesis factor 16

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.3 GO:0051946 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
1.4 7.0 GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
1.1 3.2 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.9 5.1 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 4.3 GO:0006196 AMP catabolic process(GO:0006196)
0.7 4.8 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
0.6 1.8 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.5 2.2 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.5 1.6 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241) sarcomerogenesis(GO:0048769)
0.5 2.2 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
0.5 8.5 GO:0070445 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.5 1.6 GO:0035565 regulation of pronephros size(GO:0035565)
0.5 8.8 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.5 4.6 GO:0071492 cellular response to UV-A(GO:0071492)
0.5 3.5 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.5 2.9 GO:1990034 calcium ion export from cell(GO:1990034)
0.5 1.9 GO:0097325 melanocyte proliferation(GO:0097325)
0.5 1.9 GO:1990928 response to amino acid starvation(GO:1990928)
0.5 2.3 GO:0001306 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.4 1.3 GO:0071336 submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.4 4.8 GO:0060992 response to fungicide(GO:0060992)
0.4 2.2 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.4 2.1 GO:0035603 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915)
0.4 1.8 GO:0090131 skeletal muscle thin filament assembly(GO:0030240) mesenchyme migration(GO:0090131)
0.3 5.9 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.3 2.7 GO:0001887 selenium compound metabolic process(GO:0001887)
0.3 1.7 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 3.7 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.3 1.2 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.3 0.8 GO:2001280 maternal aggressive behavior(GO:0002125) positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.3 1.1 GO:0032581 ER-dependent peroxisome organization(GO:0032581)
0.3 2.0 GO:0010044 response to aluminum ion(GO:0010044) negative regulation of serotonin secretion(GO:0014063)
0.3 0.8 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.3 2.9 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.3 1.6 GO:0015793 glycerol transport(GO:0015793)
0.3 4.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.2 1.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.2 2.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.2 1.2 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.2 0.5 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.2 0.5 GO:0060577 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.1 2.4 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 1.8 GO:0016559 peroxisome fission(GO:0016559)
0.1 1.4 GO:0050665 hydrogen peroxide biosynthetic process(GO:0050665)
0.1 1.1 GO:0045023 G0 to G1 transition(GO:0045023)
0.1 1.4 GO:0051665 membrane raft localization(GO:0051665)
0.1 4.3 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.1 0.9 GO:0045602 negative regulation of endothelial cell differentiation(GO:0045602)
0.1 0.6 GO:0006051 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
0.1 0.9 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 1.5 GO:0016540 protein autoprocessing(GO:0016540)
0.1 3.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 0.2 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.1 0.2 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.1 0.8 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.1 0.8 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.1 6.1 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 1.2 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 1.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.4 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.0 0.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 4.1 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.4 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 0.7 GO:0015879 carnitine transport(GO:0015879)
0.0 0.5 GO:0036149 phosphatidylglycerol acyl-chain remodeling(GO:0036148) phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.0 0.2 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 2.1 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 1.3 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 1.9 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 7.7 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:1904383 response to sodium phosphate(GO:1904383)
0.0 2.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.7 GO:0097503 glycosphingolipid biosynthetic process(GO:0006688) sialylation(GO:0097503)
0.0 0.6 GO:0035641 locomotory exploration behavior(GO:0035641)
0.0 12.6 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.4 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 2.0 GO:0060996 dendritic spine development(GO:0060996)
0.0 0.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.0 0.4 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 2.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.5 GO:0072534 perineuronal net(GO:0072534)
1.2 7.0 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.5 9.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.5 5.1 GO:0045180 basal cortex(GO:0045180)
0.5 1.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.4 4.2 GO:0061574 ASAP complex(GO:0061574)
0.4 3.9 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.3 3.7 GO:0097427 microtubule bundle(GO:0097427)
0.3 1.1 GO:0033263 CORVET complex(GO:0033263)
0.2 2.2 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.2 4.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.2 1.3 GO:0000322 storage vacuole(GO:0000322)
0.1 2.9 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 2.7 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 8.1 GO:1990391 DNA repair complex(GO:1990391)
0.1 1.9 GO:0071438 invadopodium membrane(GO:0071438)
0.1 1.2 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 3.2 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 19.4 GO:0008021 synaptic vesicle(GO:0008021)
0.1 2.2 GO:0044295 axonal growth cone(GO:0044295)
0.1 1.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.1 3.5 GO:0045095 keratin filament(GO:0045095)
0.1 2.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.8 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.1 2.3 GO:0071565 nBAF complex(GO:0071565)
0.0 2.7 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.1 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 6.1 GO:0005884 actin filament(GO:0005884)
0.0 1.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 5.8 GO:0030426 growth cone(GO:0030426)
0.0 2.9 GO:0072686 mitotic spindle(GO:0072686)
0.0 1.2 GO:0030673 axolemma(GO:0030673)
0.0 1.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 3.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0042629 mast cell granule(GO:0042629)
0.0 1.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.7 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.1 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.6 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 8.1 GO:0016607 nuclear speck(GO:0016607)
0.0 1.7 GO:0005811 lipid particle(GO:0005811)
0.0 2.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796) lysosomal lumen(GO:0043202)
0.0 2.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 5.2 GO:0016604 nuclear body(GO:0016604)
0.0 22.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.6 GO:0005882 intermediate filament(GO:0005882)
0.0 1.6 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.3 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.9 7.0 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.7 9.3 GO:1990239 steroid hormone binding(GO:1990239)
0.7 3.5 GO:1990254 keratin filament binding(GO:1990254)
0.7 4.9 GO:0048039 ubiquinone binding(GO:0048039)
0.7 4.8 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.6 3.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.6 1.8 GO:0052815 medium-chain acyl-CoA hydrolase activity(GO:0052815) long-chain acyl-CoA hydrolase activity(GO:0052816)
0.5 4.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.5 4.3 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.5 1.4 GO:0031753 endothelial differentiation G-protein coupled receptor binding(GO:0031753) Edg-2 lysophosphatidic acid receptor binding(GO:0031755)
0.4 1.3 GO:0032427 GBD domain binding(GO:0032427)
0.4 1.6 GO:0015254 glycerol channel activity(GO:0015254)
0.4 2.3 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.3 4.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 1.6 GO:0051373 FATZ binding(GO:0051373)
0.3 8.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 2.3 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.2 2.7 GO:0008430 selenium binding(GO:0008430)
0.2 5.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.2 2.0 GO:0008131 primary amine oxidase activity(GO:0008131)
0.2 0.7 GO:0005124 scavenger receptor binding(GO:0005124)
0.2 2.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 0.8 GO:0031893 vasopressin receptor binding(GO:0031893)
0.2 0.8 GO:0003989 acetyl-CoA carboxylase activity(GO:0003989)
0.2 0.9 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 1.2 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.1 1.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.7 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 2.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 3.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 1.8 GO:0071949 FAD binding(GO:0071949)
0.1 1.7 GO:0050811 GABA receptor binding(GO:0050811)
0.1 1.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 2.2 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 4.2 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 2.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 2.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 1.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.4 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 1.2 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.9 GO:0000049 tRNA binding(GO:0000049)
0.0 1.3 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 0.4 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 4.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.4 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 2.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.8 GO:0043531 ADP binding(GO:0043531)
0.0 1.1 GO:0030332 cyclin binding(GO:0030332)
0.0 0.5 GO:0070330 aromatase activity(GO:0070330)
0.0 1.0 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.0 0.5 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 5.1 GO:0008017 microtubule binding(GO:0008017)
0.0 1.9 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 3.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 1.8 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 9.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 2.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 3.2 GO:0003713 transcription coactivator activity(GO:0003713)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.7 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 2.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.5 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 3.5 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.2 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 8.8 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 7.0 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 3.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.3 PID FOXO PATHWAY FoxO family signaling
0.0 1.8 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 2.3 PID FGF PATHWAY FGF signaling pathway
0.0 2.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.5 ST GAQ PATHWAY G alpha q Pathway
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.2 9.1 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 6.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.1 2.3 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.1 1.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 7.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.6 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 2.3 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
0.1 2.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 1.3 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 1.4 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.2 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
0.0 1.2 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.4 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 2.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 2.5 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 0.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells