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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR2E1
Z-value: 0.89
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Transcription factors associated with NR2E1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2E1 | hg38_v1_chr6_+_108166015_108166034 | 0.31 | 3.2e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 39.5 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.9 | 26.9 | GO:1902548 | negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548) |
| 2.1 | 23.4 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 1.2 | 23.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 1.1 | 22.6 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.4 | 19.5 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 1.0 | 16.3 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 1.2 | 16.1 | GO:0060992 | response to fungicide(GO:0060992) |
| 0.5 | 12.5 | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) |
| 0.1 | 11.8 | GO:0007286 | spermatid development(GO:0007286) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 41.7 | GO:0005615 | extracellular space(GO:0005615) |
| 2.5 | 39.5 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.2 | 23.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 1.6 | 23.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 1.7 | 21.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.9 | 10.5 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.1 | 10.3 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 9.8 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 9.4 | GO:0030426 | growth cone(GO:0030426) |
| 0.5 | 9.0 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 41.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 32.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 7.8 | 23.4 | GO:0035375 | zymogen binding(GO:0035375) |
| 1.6 | 23.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 1.8 | 16.1 | GO:0046974 | histone methyltransferase activity (H3-K9 specific)(GO:0046974) |
| 0.2 | 13.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.4 | 12.0 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.4 | 10.5 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.9 | 10.4 | GO:0008559 | xenobiotic-transporting ATPase activity(GO:0008559) |
| 0.6 | 10.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 30.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 29.1 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 24.0 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.4 | 22.7 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 17.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 12.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 11.6 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 0.2 | 6.8 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.3 | 5.8 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.1 | 5.6 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 21.7 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.3 | 15.2 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.2 | 13.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 11.4 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 10.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 10.4 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.6 | 10.2 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.3 | 9.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.2 | 9.4 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.5 | 8.7 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |