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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR2E3
Z-value: 1.33
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Transcription factors associated with NR2E3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2E3 | hg38_v1_chr15_+_71810539_71810592 | 0.04 | 5.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2E3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 119.5 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 9.2 | 82.5 | GO:0070315 | G1 to G0 transition involved in cell differentiation(GO:0070315) |
| 21.8 | 65.4 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.3 | 48.4 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 41.3 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 2.8 | 33.3 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 10.1 | 30.3 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 1.1 | 28.4 | GO:0002091 | negative regulation of receptor internalization(GO:0002091) |
| 8.2 | 24.7 | GO:2000863 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 4.9 | 24.5 | GO:0035900 | response to isolation stress(GO:0035900) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 117.3 | GO:0030315 | T-tubule(GO:0030315) |
| 0.1 | 96.7 | GO:0043005 | neuron projection(GO:0043005) |
| 13.1 | 65.4 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 4.2 | 58.7 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.2 | 53.8 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.2 | 41.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.3 | 33.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.4 | 28.8 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 26.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 2.2 | 21.6 | GO:0045180 | basal cortex(GO:0045180) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 82.5 | GO:0031432 | titin binding(GO:0031432) |
| 1.7 | 81.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 13.1 | 65.4 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 1.7 | 46.8 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 1.9 | 33.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 1.2 | 33.0 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 1.7 | 28.4 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.5 | 28.4 | GO:0015485 | cholesterol binding(GO:0015485) |
| 1.0 | 24.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 6.1 | 24.5 | GO:0051538 | 3 iron, 4 sulfur cluster binding(GO:0051538) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 78.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.1 | 75.8 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.4 | 39.4 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.8 | 34.3 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.4 | 32.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.8 | 23.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.2 | 12.0 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
| 0.4 | 11.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 9.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.6 | PID RHOA PATHWAY | RhoA signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 100.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 3.0 | 65.4 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 1.4 | 37.1 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.7 | 24.2 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.6 | 23.2 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 1.2 | 20.9 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.2 | 19.3 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.6 | 15.5 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.3 | 13.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.2 | 13.2 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |