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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR2F1
Z-value: 0.90
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Transcription factors associated with NR2F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2F1 | hg38_v1_chr5_+_93584916_93585040 | 0.07 | 2.7e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2F1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 25.3 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 3.3 | 22.8 | GO:1990822 | basic amino acid transmembrane transport(GO:1990822) |
| 5.3 | 21.2 | GO:2000325 | regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327) |
| 1.1 | 20.3 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 2.9 | 17.2 | GO:0071105 | response to interleukin-11(GO:0071105) |
| 4.1 | 16.5 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 1.5 | 16.4 | GO:0035585 | calcium-mediated signaling using extracellular calcium source(GO:0035585) |
| 0.1 | 16.2 | GO:2000257 | regulation of protein activation cascade(GO:2000257) |
| 1.0 | 16.1 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.9 | 15.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 33.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.1 | 29.1 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.8 | 21.2 | GO:0030015 | CCR4-NOT core complex(GO:0030015) |
| 0.7 | 20.3 | GO:0031304 | intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305) |
| 0.2 | 17.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.6 | 16.5 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 1.0 | 15.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 15.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.4 | 14.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 14.3 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 25.3 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 1.9 | 22.8 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.4 | 22.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.6 | 21.8 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.2 | 19.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 2.8 | 19.5 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 18.4 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 18.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.5 | 15.6 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 2.4 | 14.1 | GO:0031708 | endothelin B receptor binding(GO:0031708) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 26.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 17.4 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 14.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 12.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 11.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.3 | 11.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 10.6 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.0 | 10.6 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.1 | 10.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 8.7 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 22.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.4 | 19.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 19.6 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 15.4 | REACTOME XENOBIOTICS | Genes involved in Xenobiotics |
| 0.1 | 13.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.8 | 12.9 | REACTOME SYNTHESIS OF PE | Genes involved in Synthesis of PE |
| 0.4 | 10.5 | REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 | Genes involved in Regulation of AMPK activity via LKB1 |
| 0.9 | 10.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.5 | 9.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.2 | 8.8 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |