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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR2F2
Z-value: 0.73
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Transcription factors associated with NR2F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR2F2 | hg38_v1_chr15_+_96332432_96332565 | 0.23 | 5.5e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR2F2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.9 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 3.8 | 18.8 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 1.7 | 17.2 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.1 | 11.8 | GO:0006635 | fatty acid beta-oxidation(GO:0006635) |
| 1.7 | 10.0 | GO:0006226 | dUMP biosynthetic process(GO:0006226) |
| 0.1 | 9.6 | GO:0006911 | phagocytosis, engulfment(GO:0006911) |
| 1.0 | 9.4 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 3.0 | 8.9 | GO:0002086 | diaphragm contraction(GO:0002086) |
| 0.1 | 8.8 | GO:0071470 | cellular response to osmotic stress(GO:0071470) |
| 0.5 | 8.7 | GO:0070208 | protein heterotrimerization(GO:0070208) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.4 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 21.9 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 1.6 | 17.2 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 16.9 | GO:0005743 | mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866) |
| 0.1 | 15.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 15.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 14.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 12.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.5 | 11.3 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.1 | 10.3 | GO:0005902 | microvillus(GO:0005902) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.3 | 14.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 12.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 12.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.2 | 11.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.1 | 10.2 | GO:0019003 | GDP binding(GO:0019003) |
| 3.3 | 10.0 | GO:0004132 | dCMP deaminase activity(GO:0004132) |
| 0.3 | 8.8 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.5 | 8.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 7.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 13.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 11.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 8.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 8.2 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 8.0 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 7.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.5 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.6 | 6.1 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 5.6 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 17.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 13.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 12.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 0.2 | 9.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 9.2 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |
| 0.5 | 9.1 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.4 | 8.3 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.2 | 8.1 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.1 | 7.9 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 6.2 | REACTOME TRANSLATION | Genes involved in Translation |