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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR3C1
Z-value: 1.93
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Transcription factors associated with NR3C1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR3C1 | hg38_v1_chr5_-_143404129_143404277, hg38_v1_chr5_-_143434677_143434713 | -0.12 | 8.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR3C1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr22_+_22906342 Show fit | 80.20 |
ENST00000390325.2
|
immunoglobulin lambda constant 3 (Kern-Oz+ marker) |
|
| chr22_+_22895368 Show fit | 77.49 |
ENST00000390321.2
|
immunoglobulin lambda constant 1 |
|
| chr22_+_22900976 Show fit | 74.05 |
ENST00000390323.2
|
immunoglobulin lambda constant 2 |
|
| chr2_-_89040745 Show fit | 44.12 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr22_+_22899481 Show fit | 34.04 |
ENST00000390322.2
|
immunoglobulin lambda joining 2 |
|
| chr2_-_89010515 Show fit | 33.47 |
ENST00000493819.1
|
immunoglobulin kappa variable 1-9 |
|
| chr2_-_136118142 Show fit | 32.70 |
ENST00000241393.4
|
C-X-C motif chemokine receptor 4 |
|
| chr2_-_89213917 Show fit | 32.15 |
ENST00000498435.1
|
immunoglobulin kappa variable 1-27 |
|
| chr14_-_105588322 Show fit | 31.71 |
ENST00000497872.4
ENST00000390539.2 |
immunoglobulin heavy constant alpha 2 (A2m marker) |
|
| chr5_-_150412743 Show fit | 31.10 |
ENST00000353334.11
ENST00000009530.12 ENST00000377795.7 |
CD74 molecule |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 723.9 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.5 | 184.0 | GO:0002250 | adaptive immune response(GO:0002250) |
| 0.7 | 103.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 6.5 | 58.5 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 4.2 | 41.6 | GO:0044800 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 10.4 | 31.1 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 6.8 | 27.1 | GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434) |
| 0.9 | 26.3 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 1.3 | 25.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 3.0 | 23.7 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.2 | 357.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 1.8 | 306.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.2 | 220.2 | GO:0005615 | extracellular space(GO:0005615) |
| 19.5 | 58.5 | GO:0071752 | dimeric IgA immunoglobulin complex(GO:0071750) secretory dimeric IgA immunoglobulin complex(GO:0071752) |
| 0.3 | 40.7 | GO:0035579 | specific granule membrane(GO:0035579) |
| 8.5 | 34.1 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 2.8 | 31.1 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.4 | 27.1 | GO:0015030 | Cajal body(GO:0015030) |
| 0.6 | 26.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 1.5 | 26.1 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 562.6 | GO:0003823 | antigen binding(GO:0003823) |
| 6.9 | 416.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.4 | 82.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 52.9 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 3.7 | 36.7 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 4.4 | 31.1 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 28.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 4.5 | 27.1 | GO:0055131 | C3HC4-type RING finger domain binding(GO:0055131) |
| 1.7 | 25.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 2.0 | 23.7 | GO:0008430 | selenium binding(GO:0008430) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 87.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 51.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.2 | 37.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.7 | 35.3 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.2 | 25.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 21.1 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 19.7 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 17.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 16.8 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.3 | 14.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 43.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 6.3 | 38.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 2.8 | 30.8 | REACTOME CREATION OF C4 AND C2 ACTIVATORS | Genes involved in Creation of C4 and C2 activators |
| 0.4 | 26.4 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 1.1 | 26.0 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.1 | 23.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.9 | 21.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.5 | 20.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.2 | 20.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 1.9 | 19.1 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |