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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR4A2
Z-value: 0.84
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Transcription factors associated with NR4A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A2 | hg38_v1_chr2_-_156342348_156342466 | -0.28 | 2.0e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_144095054 Show fit | 30.34 |
ENST00000318911.5
|
cytochrome c1 |
|
| chr2_-_175181663 Show fit | 18.41 |
ENST00000392541.3
ENST00000284727.9 ENST00000409194.5 |
ATP synthase membrane subunit c locus 3 |
|
| chr10_+_79347491 Show fit | 17.43 |
ENST00000448165.1
|
peptidylprolyl isomerase F |
|
| chr11_-_64246907 Show fit | 13.83 |
ENST00000309318.8
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr11_-_64246190 Show fit | 13.04 |
ENST00000392210.6
|
protein phosphatase 1 regulatory inhibitor subunit 14B |
|
| chr20_+_3796288 Show fit | 13.01 |
ENST00000439880.6
ENST00000245960.10 |
cell division cycle 25B |
|
| chr7_+_128758947 Show fit | 12.59 |
ENST00000493278.1
|
calumenin |
|
| chr10_+_79347460 Show fit | 12.44 |
ENST00000225174.8
|
peptidylprolyl isomerase F |
|
| chr5_-_134004635 Show fit | 12.31 |
ENST00000425992.2
ENST00000395044.7 ENST00000395047.6 |
voltage dependent anion channel 1 |
|
| chr1_-_17054015 Show fit | 11.51 |
ENST00000375499.8
|
succinate dehydrogenase complex iron sulfur subunit B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 35.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 7.6 | 30.3 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 10.0 | 29.9 | GO:1902445 | regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445) negative regulation of oxidative phosphorylation uncoupler activity(GO:2000276) |
| 1.7 | 27.0 | GO:0030150 | protein import into mitochondrial matrix(GO:0030150) |
| 2.0 | 21.8 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.1 | 20.2 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 3.6 | 17.9 | GO:1903588 | negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588) |
| 2.9 | 17.2 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 5.5 | 16.4 | GO:0002368 | B cell cytokine production(GO:0002368) |
| 1.3 | 15.3 | GO:0051665 | membrane raft localization(GO:0051665) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 35.2 | GO:0045275 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.6 | 32.4 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.9 | 30.0 | GO:0016469 | proton-transporting two-sector ATPase complex(GO:0016469) |
| 5.6 | 27.9 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 1.5 | 19.0 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
| 0.0 | 17.9 | GO:0005783 | endoplasmic reticulum(GO:0005783) |
| 1.3 | 17.2 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 1.8 | 16.4 | GO:0046696 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) lipopolysaccharide receptor complex(GO:0046696) |
| 2.0 | 13.8 | GO:0031415 | NatA complex(GO:0031415) |
| 0.0 | 13.6 | GO:0005635 | nuclear envelope(GO:0005635) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 31.5 | GO:0009055 | electron carrier activity(GO:0009055) |
| 1.7 | 29.9 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 1.5 | 27.9 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.5 | 24.6 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 20.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 2.4 | 19.0 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.7 | 17.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 2.7 | 16.4 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
| 3.7 | 14.8 | GO:0008177 | succinate dehydrogenase (ubiquinone) activity(GO:0008177) |
| 1.8 | 14.3 | GO:0015288 | porin activity(GO:0015288) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 29.9 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 21.4 | PID FOXO PATHWAY | FoxO family signaling |
| 0.2 | 19.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.5 | 16.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.9 | 13.0 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.2 | 9.9 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.4 | 9.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 8.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 7.4 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.1 | 6.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 87.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.5 | 36.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.2 | 25.8 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 14.4 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |
| 0.1 | 14.0 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.1 | 13.5 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.9 | 13.2 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.4 | 13.0 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.2 | 10.3 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.4 | 10.1 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |