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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR4A3
Z-value: 0.79
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Transcription factors associated with NR4A3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR4A3 | hg38_v1_chr9_+_99821846_99821862 | -0.25 | 1.9e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR4A3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_+_144095054 Show fit | 15.82 |
ENST00000318911.5
|
cytochrome c1 |
|
| chr19_+_17305801 Show fit | 9.74 |
ENST00000602206.1
ENST00000252602.2 |
mitochondrial ribosomal protein L34 |
|
| chr16_+_56657999 Show fit | 6.88 |
ENST00000568475.1
|
metallothionein 1F |
|
| chr1_+_40988513 Show fit | 6.73 |
ENST00000649215.1
|
CTP synthase 1 |
|
| chr16_-_85799554 Show fit | 6.73 |
ENST00000435200.2
|
ER membrane protein complex subunit 8 |
|
| chrX_-_53434341 Show fit | 6.72 |
ENST00000375298.4
ENST00000375304.9 ENST00000684692.1 ENST00000168216.11 |
hydroxysteroid 17-beta dehydrogenase 10 |
|
| chr5_+_1801387 Show fit | 6.59 |
ENST00000274137.10
ENST00000469176.1 |
NADH:ubiquinone oxidoreductase subunit S6 |
|
| chr11_+_35176696 Show fit | 6.42 |
ENST00000528455.5
|
CD44 molecule (Indian blood group) |
|
| chr11_+_35176639 Show fit | 6.38 |
ENST00000527889.6
|
CD44 molecule (Indian blood group) |
|
| chr11_+_35176611 Show fit | 6.33 |
ENST00000279452.10
|
CD44 molecule (Indian blood group) |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.4 | 28.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 1.9 | 24.2 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 4.9 | 19.6 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.2 | 13.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 1.3 | 12.8 | GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716) |
| 1.1 | 11.9 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 0.2 | 11.4 | GO:0006487 | protein N-linked glycosylation(GO:0006487) |
| 0.5 | 11.3 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.7 | 10.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.0 | 26.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 2.2 | 24.2 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 0.5 | 20.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 17.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.4 | 17.3 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 17.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.3 | 16.1 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 1.7 | 14.9 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 1.0 | 11.5 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 28.0 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.7 | 24.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 23.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 14.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 12.4 | GO:0009055 | electron carrier activity(GO:0009055) |
| 1.2 | 11.9 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.7 | 11.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.4 | 11.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.1 | 11.0 | GO:0008565 | protein transporter activity(GO:0008565) |
| 1.3 | 10.5 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 24.2 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 13.0 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 6.8 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 6.7 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 6.2 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 5.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 5.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 5.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.7 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 70.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.1 | 25.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.3 | 18.2 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.2 | 15.6 | REACTOME ASPARAGINE N LINKED GLYCOSYLATION | Genes involved in Asparagine N-linked glycosylation |
| 0.5 | 15.3 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.3 | 10.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 8.1 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 7.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.2 | 6.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.2 | 6.4 | REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM | Genes involved in Branched-chain amino acid catabolism |