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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NR5A2
Z-value: 1.95
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Transcription factors associated with NR5A2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NR5A2 | hg38_v1_chr1_+_200027702_200027716 | 0.42 | 1.0e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NR5A2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_-_21023318 Show fit | 93.79 |
ENST00000298684.9
ENST00000557169.5 ENST00000553563.5 |
NDRG family member 2 |
|
| chr14_-_21024092 Show fit | 80.66 |
ENST00000554398.5
|
NDRG family member 2 |
|
| chr14_-_21023954 Show fit | 79.06 |
ENST00000554094.5
|
NDRG family member 2 |
|
| chr16_+_176659 Show fit | 56.39 |
ENST00000320868.9
ENST00000397797.1 |
hemoglobin subunit alpha 1 |
|
| chr8_-_109691766 Show fit | 49.97 |
ENST00000529190.5
ENST00000422135.5 |
syntabulin |
|
| chrX_-_47574738 Show fit | 48.11 |
ENST00000640721.1
|
synapsin I |
|
| chr2_+_219627394 Show fit | 39.00 |
ENST00000373760.6
|
solute carrier family 4 member 3 |
|
| chr14_-_21022817 Show fit | 38.99 |
ENST00000554104.5
|
NDRG family member 2 |
|
| chr16_+_56589521 Show fit | 37.29 |
ENST00000200691.5
ENST00000570176.1 |
metallothionein 3 |
|
| chr8_+_22053543 Show fit | 34.79 |
ENST00000519850.5
ENST00000381470.7 |
dematin actin binding protein |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.8 | 320.3 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.2 | 163.6 | GO:0043547 | positive regulation of GTPase activity(GO:0043547) |
| 1.6 | 93.1 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 3.0 | 63.2 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 3.3 | 62.3 | GO:0015671 | oxygen transport(GO:0015671) |
| 9.2 | 55.0 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 3.1 | 53.2 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 2.5 | 53.0 | GO:1904714 | regulation of chaperone-mediated autophagy(GO:1904714) |
| 2.7 | 50.6 | GO:0097091 | synaptic vesicle clustering(GO:0097091) |
| 2.6 | 49.8 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 313.1 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 160.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 3.4 | 84.4 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 5.2 | 83.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.2 | 81.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.6 | 76.5 | GO:0043679 | axon terminus(GO:0043679) |
| 1.4 | 72.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 4.7 | 71.1 | GO:0097433 | dense body(GO:0097433) |
| 1.0 | 67.9 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 61.4 | GO:0016021 | integral component of membrane(GO:0016021) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 107.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 4.4 | 88.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 10.0 | 79.7 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 5.5 | 65.6 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.7 | 62.6 | GO:0043621 | protein self-association(GO:0043621) |
| 4.2 | 62.3 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 4.7 | 61.7 | GO:0031681 | G-protein beta-subunit binding(GO:0031681) |
| 2.0 | 58.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.7 | 55.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 3.8 | 49.8 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 241.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 2.7 | 111.6 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.6 | 43.7 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.8 | 35.1 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 32.3 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.6 | 25.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.3 | 25.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.4 | 23.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.5 | 20.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.4 | 20.5 | PID LKB1 PATHWAY | LKB1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 84.4 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.6 | 80.1 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 64.5 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 49.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.7 | 48.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 1.0 | 44.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.6 | 44.8 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 1.6 | 44.1 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.9 | 34.1 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 1.4 | 33.7 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |