ISMARA results: NR6A1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR6A1

Z-value: 0.98

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Transcription factors associated with NR6A1

Gene Symbol	Gene ID	Gene Info
NR6A1 Ensembl NCBI GeneCards UniProt	ENSG00000148200.17	NR6A1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR6A1	hg38_v1_chr9_-_124771304_124771337	0.51	8.0e-16	Click!

Activity profile of NR6A1 motif

Sorted Z-values of NR6A1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR6A1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr14_-_106507476 Show fit	19.87	ENST00000390621.3	IGHV1-45 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-45
chr14_-_105626066 Show fit	18.76	ENST00000641978.1 ENST00000390543.3	IGHG4 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant gamma 4 (G4m marker)
chr14_-_105771405 Show fit	17.29	ENST00000641136.1 ENST00000390551.6	IGHG3 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant gamma 3 (G3m marker)
chr21_-_10649835 Show fit	12.97	ENST00000622028.1	IGHV1OR21-1 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1/OR21-1 (non-functional)
chr19_-_6720641 Show fit	12.77	ENST00000245907.11	C3 Ensembl NCBI GeneCards UniProt Show fit	complement C3
chr14_-_106185387 Show fit	12.43	ENST00000390605.2	IGHV1-18 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-18
chr12_-_91180365 Show fit	12.04	ENST00000547937.5	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr14_-_106715166 Show fit	10.58	ENST00000390633.2	IGHV1-69 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-69
chr14_-_106762576 Show fit	10.39	ENST00000624687.1	IGHV1-69D Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-69D
chr14_-_106737547 Show fit	10.13	ENST00000632209.1	IGHV1-69-2 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy variable 1-69-2

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	107.8	GO:0006910	phagocytosis, recognition(GO:0006910)
4.9	19.5	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.2	19.3	GO:0006958	complement activation, classical pathway(GO:0006958)
1.1	16.8	GO:0010918	positive regulation of mitochondrial membrane potential(GO:0010918)
0.0	12.9	GO:0007283	spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.1	12.7	GO:0070268	cornification(GO:0070268)
0.9	12.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.3	11.5	GO:1902847	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.6	11.5	GO:0071786	endoplasmic reticulum tubular network organization(GO:0071786)
0.4	11.1	GO:0009435	NAD biosynthetic process(GO:0009435)

Showing 1 to 10 of 177 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	108.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.2	26.7	GO:0072562	blood microparticle(GO:0072562)
0.0	23.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	12.7	GO:0005882	intermediate filament(GO:0005882)
0.9	12.0	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.3	11.6	GO:0001520	outer dense fiber(GO:0001520)
0.9	11.5	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.5	7.9	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.4	7.6	GO:0031089	platelet dense granule lumen(GO:0031089)
0.1	6.9	GO:0035580	specific granule lumen(GO:0035580)

Showing 1 to 10 of 86 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.8	108.9	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	37.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.2	19.6	GO:0005518	collagen binding(GO:0005518)
0.5	16.8	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.6	14.8	GO:0051787	misfolded protein binding(GO:0051787)
0.0	12.8	GO:0005198	structural molecule activity(GO:0005198)
2.8	11.1	GO:0061769	ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.0	7.8	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.2	7.6	GO:0030742	GTP-dependent protein binding(GO:0030742)
0.0	7.6	GO:0003714	transcription corepressor activity(GO:0003714)

Showing 1 to 10 of 124 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	21.2	PID IL4 2PATHWAY	IL4-mediated signaling events
0.5	12.8	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	12.0	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	11.8	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.1	6.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.2	6.7	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.1	6.7	PID BCR 5PATHWAY	BCR signaling pathway
0.1	6.5	PID RAS PATHWAY	Regulation of Ras family activation
0.1	5.7	PID PLK1 PATHWAY	PLK1 signaling events
0.2	5.5	PID IL27 PATHWAY	IL27-mediated signaling events

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	16.9	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.4	12.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	11.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	8.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.3	7.5	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	7.0	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.1	6.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	6.8	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	6.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	5.4	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 57 entries

Results for NR6A1

Z-value: 0.98

Motif logo

Transcription factors associated with NR6A1

Activity-expression correlation:

Activity profile of NR6A1 motif

Sorted Z-values of NR6A1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of NR6A1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: