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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NRF1
Z-value: 5.80
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Transcription factors associated with NRF1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NRF1 | hg38_v1_chr7_+_129611680_129611760 | -0.37 | 1.5e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of NRF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.9 | 711.6 | GO:0050434 | positive regulation of viral transcription(GO:0050434) |
| 5.1 | 547.8 | GO:0051439 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 1.6 | 448.5 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 5.0 | 404.6 | GO:0048208 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 5.8 | 370.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 38.8 | 310.5 | GO:0045905 | translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905) |
| 8.1 | 297.9 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 3.7 | 280.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 59.8 | 239.2 | GO:1904045 | cellular response to aldosterone(GO:1904045) |
| 17.0 | 238.5 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 640.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 22.2 | 598.2 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 1.1 | 560.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.2 | 455.7 | GO:0070062 | extracellular exosome(GO:0070062) |
| 28.2 | 450.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.5 | 371.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 6.3 | 346.8 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 2.4 | 298.1 | GO:0005840 | ribosome(GO:0005840) |
| 10.3 | 297.9 | GO:0070971 | endoplasmic reticulum exit site(GO:0070971) |
| 23.6 | 283.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.2 | 561.3 | GO:0001055 | RNA polymerase II activity(GO:0001055) |
| 2.7 | 543.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 26.8 | 535.0 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 12.0 | 372.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 6.7 | 360.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.1 | 316.3 | GO:0044389 | ubiquitin-like protein ligase binding(GO:0044389) |
| 52.2 | 313.1 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 1.3 | 310.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 5.9 | 279.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 34.5 | 275.9 | GO:0015288 | porin activity(GO:0015288) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 592.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 10.4 | 531.4 | PID BARD1 PATHWAY | BARD1 signaling events |
| 2.7 | 345.0 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 3.3 | 263.9 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 3.2 | 261.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 4.5 | 248.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 8.0 | 222.8 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 6.3 | 221.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 2.0 | 213.5 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 5.3 | 189.6 | PID ATM PATHWAY | ATM pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.6 | 639.3 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 7.1 | 604.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.3 | 520.4 | REACTOME TRANSLATION | Genes involved in Translation |
| 19.9 | 457.2 | REACTOME VIRAL MESSENGER RNA SYNTHESIS | Genes involved in Viral Messenger RNA Synthesis |
| 10.0 | 360.7 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 4.8 | 352.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 9.7 | 328.2 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 5.3 | 309.6 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 11.9 | 274.5 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 3.4 | 270.0 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |