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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for OLIG1
Z-value: 0.62
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Transcription factors associated with OLIG1
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_111793871 Show fit | 8.51 |
ENST00000368667.6
|
FYN proto-oncogene, Src family tyrosine kinase |
|
| chr19_+_18097763 Show fit | 8.42 |
ENST00000262811.10
|
microtubule associated serine/threonine kinase 3 |
|
| chr3_-_39280432 Show fit | 7.99 |
ENST00000542107.5
ENST00000435290.1 |
C-X3-C motif chemokine receptor 1 |
|
| chr3_-_18438767 Show fit | 7.91 |
ENST00000454909.6
|
SATB homeobox 1 |
|
| chr1_+_158930778 Show fit | 7.30 |
ENST00000458222.5
|
pyrin and HIN domain family member 1 |
|
| chr1_+_244051275 Show fit | 7.14 |
ENST00000358704.4
|
zinc finger and BTB domain containing 18 |
|
| chr3_-_39281261 Show fit | 6.49 |
ENST00000541347.5
ENST00000412814.1 |
C-X3-C motif chemokine receptor 1 |
|
| chr5_-_11588842 Show fit | 6.44 |
ENST00000503622.5
|
catenin delta 2 |
|
| chr3_-_121660892 Show fit | 6.35 |
ENST00000428394.6
ENST00000314583.8 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr6_-_69699124 Show fit | 6.10 |
ENST00000651675.1
|
LMBR1 domain containing 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.5 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
| 0.1 | 10.5 | GO:0060997 | dendritic spine morphogenesis(GO:0060997) |
| 1.6 | 9.7 | GO:1903690 | negative regulation of wound healing, spreading of epidermal cells(GO:1903690) |
| 0.6 | 9.5 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.9 | 8.5 | GO:1902951 | negative regulation of dendritic spine maintenance(GO:1902951) |
| 0.6 | 6.6 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
| 0.4 | 6.4 | GO:0030854 | positive regulation of granulocyte differentiation(GO:0030854) |
| 0.3 | 6.2 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.0 | 6.1 | GO:0038016 | insulin receptor internalization(GO:0038016) |
| 0.2 | 6.1 | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation(GO:1904707) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.4 | GO:0070821 | tertiary granule membrane(GO:0070821) |
| 0.4 | 14.5 | GO:0032809 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 0.1 | 14.1 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 13.0 | GO:0043204 | perikaryon(GO:0043204) |
| 0.1 | 10.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 1.0 | 9.7 | GO:0045180 | basal cortex(GO:0045180) |
| 0.0 | 8.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 7.9 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.6 | 6.6 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.3 | 6.6 | GO:0097342 | ripoptosome(GO:0097342) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 14.5 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 0.0 | 12.9 | GO:0004672 | protein kinase activity(GO:0004672) |
| 0.0 | 12.1 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 10.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.4 | 9.8 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 1.7 | 8.5 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.5 | 8.2 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.1 | 7.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 7.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 6.6 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.0 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.3 | 8.5 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 7.9 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 7.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.2 | 6.6 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 5.3 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 4.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 4.5 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.1 | 4.5 | ST JNK MAPK PATHWAY | JNK MAPK Pathway |
| 0.2 | 4.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.5 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 11.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 8.9 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.5 | 8.5 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 8.3 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.1 | 7.9 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 6.6 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 6.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 5.7 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.2 | 5.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |