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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for OLIG2_NEUROD1_ATOH1
Z-value: 1.10
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Transcription factors associated with OLIG2_NEUROD1_ATOH1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATOH1 | hg38_v1_chr4_+_93828746_93828758 | -0.19 | 5.5e-03 | Click! |
| OLIG2 | hg38_v1_chr21_+_33025927_33025942 | 0.10 | 1.3e-01 | Click! |
| NEUROD1 | hg38_v1_chr2_-_181680490_181680525 | 0.06 | 3.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of OLIG2_NEUROD1_ATOH1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 14.9 | 178.8 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.4 | 80.0 | GO:0006261 | DNA-dependent DNA replication(GO:0006261) |
| 4.2 | 41.8 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 7.2 | 28.8 | GO:0001519 | peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179) |
| 3.1 | 27.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.2 | 23.1 | GO:0032392 | DNA geometric change(GO:0032392) |
| 1.3 | 19.6 | GO:0000338 | protein deneddylation(GO:0000338) |
| 4.7 | 18.9 | GO:0099640 | axo-dendritic protein transport(GO:0099640) |
| 1.5 | 18.2 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 4.1 | 16.3 | GO:0072660 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 178.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 96.4 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.0 | 62.3 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 48.8 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.2 | 43.8 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 23.6 | GO:0005694 | chromosome(GO:0005694) |
| 0.4 | 21.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.4 | 18.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.2 | 15.9 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 14.5 | GO:0005770 | late endosome(GO:0005770) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 184.0 | GO:0005178 | integrin binding(GO:0005178) |
| 2.0 | 78.6 | GO:0070182 | DNA polymerase binding(GO:0070182) |
| 2.5 | 54.9 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.9 | 52.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.1 | 29.6 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 7.2 | 28.8 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.1 | 25.9 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 4.1 | 24.3 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.9 | 20.6 | GO:0000400 | four-way junction DNA binding(GO:0000400) |
| 1.1 | 19.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 202.5 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 0.8 | 90.9 | ST FAS SIGNALING PATHWAY | Fas Signaling Pathway |
| 0.2 | 20.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 11.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 11.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 11.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.2 | 10.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 9.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 5.3 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 4.5 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 169.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 18.9 | REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 | Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0) |
| 1.1 | 14.9 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.4 | 14.7 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.4 | 14.6 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.5 | 11.7 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 10.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.3 | 9.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 9.3 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.3 | 9.1 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |