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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for OTX1
Z-value: 0.69
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Transcription factors associated with OTX1
Network of associatons between targets according to the STRING database.
First level regulatory network of OTX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.6 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.2 | 19.5 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 2.9 | 14.3 | GO:2000035 | regulation of stem cell division(GO:2000035) |
| 2.6 | 13.0 | GO:1902019 | regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019) |
| 0.1 | 12.0 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.6 | 11.4 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.5 | 11.2 | GO:0098779 | mitophagy in response to mitochondrial depolarization(GO:0098779) |
| 0.7 | 10.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 2.0 | 10.0 | GO:1902896 | terminal web assembly(GO:1902896) |
| 0.1 | 9.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.4 | 23.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 12.5 | GO:0005814 | centriole(GO:0005814) |
| 0.1 | 12.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.9 | 11.4 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 11.0 | GO:0005874 | microtubule(GO:0005874) |
| 0.1 | 10.2 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.7 | 10.0 | GO:1990357 | terminal web(GO:1990357) |
| 0.1 | 9.6 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 9.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 23.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 23.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 19.7 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.1 | 17.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.2 | 12.9 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.1 | 12.6 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 1.3 | 12.0 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.9 | 11.8 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.2 | 11.2 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.4 | 10.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 11.2 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 10.9 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 8.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 7.8 | PID ARF6 PATHWAY | Arf6 signaling events |
| 0.2 | 6.1 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.3 | 5.9 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.1 | 5.8 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.1 | 5.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 4.2 | PID AURORA B PATHWAY | Aurora B signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.2 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 14.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.4 | 11.2 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |
| 0.1 | 9.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.1 | 8.7 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 0.2 | 8.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.1 | 7.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.0 | 7.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 7.0 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 6.9 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |