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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PAX3
Z-value: 0.92
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Transcription factors associated with PAX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX3 | hg38_v1_chr2_-_222298808_222298895 | 0.35 | 8.7e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.0 | GO:0007602 | phototransduction(GO:0007602) |
| 0.4 | 19.8 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.4 | 19.3 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.6 | 19.1 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
| 1.1 | 13.8 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 4.1 | 12.2 | GO:0097476 | spinal cord motor neuron migration(GO:0097476) lateral motor column neuron migration(GO:0097477) |
| 3.0 | 12.1 | GO:0019355 | nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628) |
| 2.6 | 10.2 | GO:1903070 | negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070) |
| 0.7 | 9.9 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 9.8 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 70.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 57.4 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 19.3 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 14.4 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 13.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.8 | 8.1 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 0.2 | 7.7 | GO:0080008 | Cul4-RING E3 ubiquitin ligase complex(GO:0080008) |
| 0.4 | 7.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.2 | 6.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.1 | 5.6 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 26.4 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.7 | 19.8 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 1.4 | 19.3 | GO:0001075 | transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) |
| 1.1 | 19.1 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.4 | 15.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.3 | 13.8 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 3.1 | 12.2 | GO:0070326 | very-low-density lipoprotein particle receptor binding(GO:0070326) |
| 3.0 | 12.1 | GO:0000309 | nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) |
| 1.5 | 10.2 | GO:1904288 | BAT3 complex binding(GO:1904288) |
| 0.8 | 9.9 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.3 | 12.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 10.4 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 9.9 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.1 | 7.5 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 6.1 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 6.1 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.1 | 4.6 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 4.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 3.1 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 19.3 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.8 | 19.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.2 | 12.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 10.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.4 | 9.9 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.4 | 9.6 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.4 | 8.5 | REACTOME SIGNAL ATTENUATION | Genes involved in Signal attenuation |
| 0.1 | 7.6 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 7.5 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 6.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |