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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PAX4
Z-value: 1.07
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Transcription factors associated with PAX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX4 | hg38_v1_chr7_-_127618137_127618145 | 0.16 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX4
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_32439866 Show fit | 35.73 |
ENST00000374982.5
ENST00000395388.7 |
major histocompatibility complex, class II, DR alpha |
|
| chr4_-_83109843 Show fit | 29.69 |
ENST00000411416.6
|
placenta associated 8 |
|
| chr1_+_26317950 Show fit | 27.46 |
ENST00000374213.3
|
CD52 molecule |
|
| chr6_+_32637419 Show fit | 27.35 |
ENST00000374949.2
|
major histocompatibility complex, class II, DQ alpha 1 |
|
| chr2_-_136118142 Show fit | 26.29 |
ENST00000241393.4
|
C-X-C motif chemokine receptor 4 |
|
| chr22_-_17219571 Show fit | 25.43 |
ENST00000610390.4
|
adenosine deaminase 2 |
|
| chr22_-_17219424 Show fit | 24.86 |
ENST00000649540.1
ENST00000399837.8 ENST00000543038.1 |
adenosine deaminase 2 |
|
| chr2_-_136116165 Show fit | 24.81 |
ENST00000409817.1
|
C-X-C motif chemokine receptor 4 |
|
| chr6_+_31586269 Show fit | 22.63 |
ENST00000438075.7
|
leukocyte specific transcript 1 |
|
| chr6_+_31586124 Show fit | 20.66 |
ENST00000418507.6
ENST00000376096.5 ENST00000376099.5 ENST00000376110.7 |
leukocyte specific transcript 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 67.1 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 5.1 | 51.1 | GO:0039663 | fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800) |
| 10.1 | 50.3 | GO:0046103 | adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103) |
| 0.4 | 46.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 5.1 | 45.6 | GO:0072564 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 11.9 | 35.7 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 1.6 | 29.7 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.7 | 27.5 | GO:0045730 | respiratory burst(GO:0045730) |
| 1.2 | 27.1 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 27.0 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 80.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.6 | 73.8 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.2 | 55.4 | GO:0005770 | late endosome(GO:0005770) |
| 1.2 | 45.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 41.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 32.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 27.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 20.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.8 | 20.2 | GO:0060171 | stereocilium membrane(GO:0060171) |
| 0.4 | 18.6 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 80.4 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 5.1 | 51.1 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 5.6 | 50.3 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 5.7 | 45.6 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 1.4 | 28.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 4.5 | 27.1 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 5.9 | 23.7 | GO:0030107 | HLA-A specific inhibitory MHC class I receptor activity(GO:0030107) |
| 0.0 | 23.3 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.5 | 20.8 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.3 | 18.6 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 59.4 | PID S1P S1P3 PATHWAY | S1P3 pathway |
| 0.7 | 39.1 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.2 | 32.2 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 26.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.5 | 19.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 12.3 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.3 | 9.6 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.3 | 8.6 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.2 | 7.7 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 7.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.5 | 51.1 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.5 | 47.2 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.4 | 44.9 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 2.2 | 44.7 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.4 | 28.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.2 | 27.1 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.6 | 18.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.7 | 17.3 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.2 | 16.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.3 | 9.6 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |