ISMARA results: PAX5

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PAX5

Z-value: 1.66

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Transcription factors associated with PAX5

Gene Symbol	Gene ID	Gene Info
PAX5 Ensembl NCBI GeneCards UniProt	ENSG00000196092.14	PAX5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PAX5	hg38_v1_chr9_-_37025733_37025753	0.56	2.5e-19	Click!

Activity profile of PAX5 motif

Sorted Z-values of PAX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX5

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Promoter	Score	Transcript	Gene	Gene Info
chr9_+_136980211 Show fit	31.30	ENST00000444903.2	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase
chr9_+_136977496 Show fit	18.32	ENST00000371625.8 ENST00000457950.5	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase
chr12_-_91146195 Show fit	17.09	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt Show fit	decorin
chr22_+_22822658 Show fit	16.56	ENST00000620395.2	IGLV2-8 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda variable 2-8
chr22_+_22922594 Show fit	16.49	ENST00000390331.3	IGLC7 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin lambda constant 7
chr2_+_90159840 Show fit	16.40	ENST00000377032.5	IGKV1D-12 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1D-12
chr17_-_57850010 Show fit	16.20	ENST00000313608.13 ENST00000578444.1 ENST00000579380.1	MRPS23 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein S23
chr16_+_85908988 Show fit	16.12	ENST00000566369.1	IRF8 Ensembl NCBI GeneCards UniProt Show fit	interferon regulatory factor 8
chr14_-_105856183 Show fit	16.07	ENST00000637539.2 ENST00000390559.6	IGHM Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin heavy constant mu
chr4_+_127965429 Show fit	15.28	ENST00000513371.1 ENST00000611882.1	ABHD18 Ensembl NCBI GeneCards UniProt Show fit	abhydrolase domain containing 18

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	447.2	GO:0006958	complement activation, classical pathway(GO:0006958)
0.7	95.8	GO:0002377	immunoglobulin production(GO:0002377)
2.1	76.4	GO:0045187	regulation of circadian sleep/wake cycle, sleep(GO:0045187)
1.5	42.7	GO:1904659	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.4	36.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
1.2	34.1	GO:0032011	ARF protein signal transduction(GO:0032011)
0.1	34.0	GO:0043547	positive regulation of GTPase activity(GO:0043547)
2.4	31.8	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
4.3	30.3	GO:0070560	protein secretion by platelet(GO:0070560)
0.6	29.7	GO:0086010	membrane depolarization during action potential(GO:0086010)

Showing 1 to 10 of 928 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	181.6	GO:0016021	integral component of membrane(GO:0016021)
1.0	159.5	GO:0072562	blood microparticle(GO:0072562)
0.1	159.2	GO:0005615	extracellular space(GO:0005615)
2.9	138.8	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	65.2	GO:0009897	external side of plasma membrane(GO:0009897)
3.0	56.4	GO:0042613	MHC class II protein complex(GO:0042613)
0.5	50.7	GO:0005796	Golgi lumen(GO:0005796)
2.0	49.9	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.4	44.7	GO:0043204	perikaryon(GO:0043204)
0.5	44.4	GO:0005923	bicellular tight junction(GO:0005923) occluding junction(GO:0070160)

Showing 1 to 10 of 290 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	285.0	GO:0003823	antigen binding(GO:0003823)
2.9	173.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	103.1	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.3	67.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	50.2	GO:0017137	Rab GTPase binding(GO:0017137)
0.2	50.2	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
12.4	49.6	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.5	48.8	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	48.7	GO:0005096	GTPase activator activity(GO:0005096)
0.8	44.7	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 636 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	100.4	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.1	54.2	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	38.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.6	34.7	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.9	30.0	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.5	29.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.4	27.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.4	26.0	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.5	25.8	PID IL12 2PATHWAY	IL12-mediated signaling events
0.6	24.4	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	97.1	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
0.9	79.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	70.8	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.0	63.0	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.4	55.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4	47.1	REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	Genes involved in Class A/1 (Rhodopsin-like receptors)
0.9	40.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.3	40.0	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
1.5	35.5	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.5	33.8	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions

Showing 1 to 10 of 141 entries

Results for PAX5

Z-value: 1.66

Motif logo

Transcription factors associated with PAX5

Activity-expression correlation:

Activity profile of PAX5 motif

Sorted Z-values of PAX5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX5

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: