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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PAX6
Z-value: 0.72
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Transcription factors associated with PAX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX6 | hg38_v1_chr11_-_31810657_31810679, hg38_v1_chr11_-_31811140_31811149, hg38_v1_chr11_-_31817904_31817924, hg38_v1_chr11_-_31805795_31805857, hg38_v1_chr11_-_31811034_31811057, hg38_v1_chr11_-_31812171_31812342 | 0.19 | 4.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 28.6 | GO:0070650 | endoplasmic reticulum polarization(GO:0061163) actin filament bundle retrograde transport(GO:0061573) actin filament bundle distribution(GO:0070650) |
| 3.8 | 15.2 | GO:0070981 | L-asparagine biosynthetic process(GO:0070981) L-asparagine metabolic process(GO:0070982) |
| 1.0 | 15.2 | GO:1903760 | regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760) |
| 1.0 | 13.4 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.2 | 13.3 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.0 | 12.6 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 1.2 | 12.2 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.3 | 11.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.1 | 10.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.5 | 10.3 | GO:0031914 | negative regulation of synaptic plasticity(GO:0031914) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 28.6 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.9 | 19.0 | GO:0035748 | myelin sheath abaxonal region(GO:0035748) |
| 0.0 | 16.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.2 | 12.2 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 11.8 | GO:0044306 | neuron projection terminus(GO:0044306) |
| 0.9 | 11.7 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.3 | 10.6 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 2.1 | 10.3 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.1 | 8.5 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.2 | 5.1 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.2 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.2 | 16.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 15.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 3.0 | 15.2 | GO:0004066 | asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066) |
| 0.8 | 15.2 | GO:0097016 | L27 domain binding(GO:0097016) |
| 0.3 | 14.5 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.4 | 11.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.0 | 10.6 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 3.4 | 10.3 | GO:0030549 | acetylcholine receptor activator activity(GO:0030549) |
| 0.0 | 9.7 | GO:0019787 | ubiquitin-like protein transferase activity(GO:0019787) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.2 | 15.2 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 11.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 10.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 6.1 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 4.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 2.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 2.3 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 19.9 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.5 | 15.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |
| 0.4 | 10.3 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 6.7 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.3 | 6.1 | REACTOME FGFR4 LIGAND BINDING AND ACTIVATION | Genes involved in FGFR4 ligand binding and activation |
| 0.2 | 5.1 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 4.4 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.1 | 4.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 3.7 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 3.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |