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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PAX7_NOBOX
Z-value: 0.90
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Transcription factors associated with PAX7_NOBOX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX7 | hg38_v1_chr1_+_18631513_18631529 | 0.48 | 5.8e-14 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX7_NOBOX
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_91153149 Show fit | 25.52 |
ENST00000550758.1
|
decorin |
|
| chr17_+_1771688 Show fit | 20.20 |
ENST00000572048.1
ENST00000573763.1 |
serpin family F member 1 |
|
| chr19_+_49513353 Show fit | 17.55 |
ENST00000596975.5
|
Fc fragment of IgG receptor and transporter |
|
| chr10_-_97445850 Show fit | 13.64 |
ENST00000477692.6
ENST00000485122.6 ENST00000370886.9 ENST00000370885.8 ENST00000370902.8 ENST00000370884.5 |
exosome component 1 |
|
| chr11_+_95789965 Show fit | 12.96 |
ENST00000537677.5
|
centrosomal protein 57 |
|
| chr2_+_90209873 Show fit | 12.89 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr9_-_95317671 Show fit | 12.87 |
ENST00000490972.7
ENST00000647778.1 ENST00000649611.1 ENST00000289081.8 |
FA complementation group C |
|
| chr18_+_31591869 Show fit | 12.79 |
ENST00000237014.8
|
transthyretin |
|
| chr2_+_68734861 Show fit | 12.27 |
ENST00000467265.5
|
Rho GTPase activating protein 25 |
|
| chr2_+_68734773 Show fit | 11.29 |
ENST00000409202.8
|
Rho GTPase activating protein 25 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 60.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 33.2 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 4.6 | 27.5 | GO:0046092 | deoxycytidine metabolic process(GO:0046092) |
| 2.0 | 25.5 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.7 | 23.5 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 7.4 | 22.1 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 2.9 | 20.2 | GO:0060770 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) |
| 0.6 | 19.1 | GO:0071711 | basement membrane organization(GO:0071711) |
| 0.5 | 14.3 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 0.3 | 13.6 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 83.5 | GO:0005615 | extracellular space(GO:0005615) |
| 2.0 | 25.5 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 22.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.0 | 20.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.4 | 16.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 15.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.1 | 14.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 14.0 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 1.0 | 13.6 | GO:0000176 | nuclear exosome (RNase complex)(GO:0000176) |
| 1.1 | 11.9 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 49.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 45.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 37.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.3 | 33.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.9 | 27.5 | GO:0004137 | deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797) |
| 0.4 | 23.5 | GO:0015485 | cholesterol binding(GO:0015485) |
| 5.5 | 22.1 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 20.3 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.0 | 18.3 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 14.0 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 60.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 23.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.5 | 21.7 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.2 | 16.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 16.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 15.6 | PID CXCR4 PATHWAY | CXCR4-mediated signaling events |
| 0.2 | 12.7 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.1 | 10.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.8 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
| 0.1 | 9.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.9 | 25.5 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 22.8 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 1.1 | 13.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |
| 0.3 | 12.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.5 | 11.7 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.5 | 11.5 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.2 | 11.4 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.5 | 9.9 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.4 | 9.5 | REACTOME HDL MEDIATED LIPID TRANSPORT | Genes involved in HDL-mediated lipid transport |