Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PBX1
Z-value: 0.96
Motif logo
Transcription factors associated with PBX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX1 | hg38_v1_chr1_+_164559766_164559823 | -0.39 | 2.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.5 | 38.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.9 | 27.5 | GO:0042276 | error-prone translesion synthesis(GO:0042276) |
| 2.4 | 26.9 | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 1.6 | 24.4 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.3 | 22.5 | GO:0042267 | natural killer cell mediated cytotoxicity(GO:0042267) |
| 1.6 | 22.4 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 7.3 | 21.8 | GO:0006781 | succinyl-CoA pathway(GO:0006781) |
| 6.9 | 20.7 | GO:0098905 | regulation of bundle of His cell action potential(GO:0098905) |
| 0.2 | 20.3 | GO:0006903 | vesicle targeting(GO:0006903) |
| 1.7 | 19.1 | GO:1903944 | regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 36.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.5 | 27.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 26.9 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.1 | 25.6 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 0.5 | 24.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.3 | 22.7 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 20.7 | GO:0014704 | intercalated disc(GO:0014704) |
| 0.9 | 19.1 | GO:0097342 | ripoptosome(GO:0097342) |
| 0.1 | 17.4 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 16.9 | GO:0042383 | sarcolemma(GO:0042383) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 32.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.4 | 28.7 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.6 | 23.3 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.7 | 22.9 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 5.4 | 21.8 | GO:0004775 | succinate-CoA ligase (ADP-forming) activity(GO:0004775) |
| 0.1 | 20.8 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 2.6 | 20.7 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.2 | 19.9 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.6 | 19.1 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
| 0.1 | 19.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 33.0 | PID ATR PATHWAY | ATR signaling pathway |
| 0.6 | 19.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.3 | 17.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 16.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.4 | 15.6 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.6 | 11.6 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 11.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 10.9 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 10.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.2 | 10.0 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 45.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 1.8 | 27.5 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 1.0 | 26.6 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.4 | 26.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 21.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.6 | 19.1 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.1 | 18.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 17.4 | REACTOME DESTABILIZATION OF MRNA BY KSRP | Genes involved in Destabilization of mRNA by KSRP |
| 0.1 | 12.8 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.6 | 11.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |