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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PBX1

Z-value: 0.96

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Transcription factors associated with PBX1

Gene Symbol Gene ID Gene Info
PBX1
ENSG00000185630.19 PBX1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX1hg38_v1_chr1_+_164559766_164559823-0.392.3e-09Click!

Activity profile of PBX1 motif

Sorted Z-values of PBX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_83035159 24.38 ENST00000509317.5
ENST00000264389.7
ENST00000503682.5
ENST00000511653.1
COPS4
COP9 signalosome subunit 4
chr9_+_137241277 22.88 ENST00000340384.5
TUBB4B
tubulin beta 4B class IVb
chr21_-_29061351 22.41 ENST00000432178.5
CCT8
chaperonin containing TCP1 subunit 8
chr13_-_48037934 21.76 ENST00000646804.1
ENST00000643246.1
SUCLA2
succinate-CoA ligase ADP-forming subunit beta
chr17_+_8288637 20.75 ENST00000407006.8
ENST00000226105.11
ENST00000580434.5
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chrX_+_120604199 20.70 ENST00000371315.3
MCTS1
MCTS1 re-initiation and release factor
chr1_+_236394268 17.93 ENST00000334232.9
EDARADD
EDAR associated death domain
chrX_+_120604084 17.49 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr1_+_146949314 17.30 ENST00000617844.4
ENST00000611443.4
NBPF12
NBPF member 12
chr17_-_1229706 16.70 ENST00000574139.7
ABR
ABR activator of RhoGEF and GTPase
chr7_+_16661182 15.12 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
BZW2
basic leucine zipper and W2 domains 2
chr2_-_199457931 14.84 ENST00000417098.6
SATB2
SATB homeobox 2
chr2_+_201071984 14.56 ENST00000237889.9
ENST00000433898.5
ENST00000684175.1
ENST00000682325.1
ENST00000454214.1
ENST00000684420.1
NDUFB3
NADH:ubiquinone oxidoreductase subunit B3
chr8_+_97775775 13.71 ENST00000521545.7
LAPTM4B
lysosomal protein transmembrane 4 beta
chr14_-_54441325 13.04 ENST00000556113.1
ENST00000553660.5
ENST00000216416.9
ENST00000395573.8
ENST00000557690.5
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr2_-_199458689 12.10 ENST00000443023.5
SATB2
SATB homeobox 2
chr7_-_7640971 11.94 ENST00000396682.6
RPA3
replication protein A3
chrX_+_71254781 11.58 ENST00000677446.1
NONO
non-POU domain containing octamer binding
chr8_-_100953331 11.03 ENST00000353245.7
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chrX_+_56563569 11.03 ENST00000338222.7
UBQLN2
ubiquilin 2
chr12_-_54259531 10.90 ENST00000550411.5
ENST00000439541.6
CBX5
chromobox 5
chr5_+_66144288 10.49 ENST00000334121.11
SREK1
splicing regulatory glutamic acid and lysine rich protein 1
chr2_+_218245426 10.06 ENST00000456575.1
ARPC2
actin related protein 2/3 complex subunit 2
chr5_-_87412854 10.02 ENST00000504878.1
ENST00000256897.9
CCNH
cyclin H
chr6_-_27146841 9.84 ENST00000356950.2
H2BC12
H2B clustered histone 12
chr10_+_58269132 9.80 ENST00000333926.6
CISD1
CDGSH iron sulfur domain 1
chr3_+_159839847 9.70 ENST00000445224.6
SCHIP1
schwannomin interacting protein 1
chr5_+_163437569 9.69 ENST00000512163.5
ENST00000393929.5
ENST00000510097.5
ENST00000340828.7
ENST00000511490.4
ENST00000510664.5
CCNG1
cyclin G1
chr15_-_37101205 9.44 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr17_+_47522931 9.24 ENST00000525007.5
ENST00000530173.6
NPEPPS
aminopeptidase puromycin sensitive
chr9_-_2844058 9.09 ENST00000397885.3
PUM3
pumilio RNA binding family member 3
chr11_+_34916611 8.93 ENST00000227868.9
ENST00000430469.6
ENST00000533262.1
PDHX
pyruvate dehydrogenase complex component X
chr2_+_264913 8.61 ENST00000439645.6
ENST00000405233.5
ENST00000272065.10
ACP1
acid phosphatase 1
chr3_+_159852933 8.46 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr7_+_48924559 8.42 ENST00000650262.1
CDC14C
cell division cycle 14C
chr2_+_180980347 8.40 ENST00000602959.5
ENST00000602479.5
ENST00000392415.6
ENST00000602291.5
UBE2E3
ubiquitin conjugating enzyme E2 E3
chr1_-_27914513 8.26 ENST00000313433.11
ENST00000373912.8
ENST00000444045.1
RPA2
replication protein A2
chr2_+_201132769 8.17 ENST00000494258.5
CFLAR
CASP8 and FADD like apoptosis regulator
chr3_+_139344530 7.91 ENST00000478464.5
MRPS22
mitochondrial ribosomal protein S22
chr5_-_179617581 7.90 ENST00000523449.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr22_+_31399585 7.88 ENST00000331457.9
DRG1
developmentally regulated GTP binding protein 1
chr14_+_64504743 7.86 ENST00000683701.1
ZBTB1
zinc finger and BTB domain containing 1
chr3_-_15797930 7.83 ENST00000683139.1
ANKRD28
ankyrin repeat domain 28
chr1_-_3796478 7.72 ENST00000378251.3
LRRC47
leucine rich repeat containing 47
chr1_-_27914717 7.32 ENST00000373909.7
RPA2
replication protein A2
chr12_-_102061946 7.16 ENST00000240079.11
WASHC3
WASH complex subunit 3
chr3_-_129440007 7.07 ENST00000503197.5
ENST00000249910.5
ENST00000507208.1
ENST00000393278.6
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr12_-_102062079 7.03 ENST00000545679.5
WASHC3
WASH complex subunit 3
chr11_-_34916310 6.96 ENST00000395787.4
APIP
APAF1 interacting protein
chr2_+_264869 6.95 ENST00000272067.10
ENST00000407983.7
ACP1
acid phosphatase 1
chr3_-_15798184 6.78 ENST00000624145.3
ANKRD28
ankyrin repeat domain 28
chr15_-_64381431 6.67 ENST00000558008.3
ENST00000300035.9
ENST00000559519.5
ENST00000380258.6
PCLAF
PCNA clamp associated factor
chr1_-_100895132 6.65 ENST00000535414.5
EXTL2
exostosin like glycosyltransferase 2
chr2_+_190880834 6.64 ENST00000338435.8
GLS
glutaminase
chr17_+_47651061 6.63 ENST00000540627.5
KPNB1
karyopherin subunit beta 1
chr10_+_5446601 6.47 ENST00000449083.5
ENST00000380359.3
NET1
neuroepithelial cell transforming 1
chr11_-_18526885 6.37 ENST00000251968.4
ENST00000536719.5
TSG101
tumor susceptibility 101
chr8_-_100952918 6.37 ENST00000395957.6
ENST00000395948.6
ENST00000457309.2
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
chr21_-_33641721 6.34 ENST00000399442.1
ENST00000413017.2
ENST00000445393.5
ENST00000417979.5
ENST00000381554.8
ENST00000426935.5
ENST00000381540.7
ENST00000361534.6
CRYZL1
crystallin zeta like 1
chr3_-_33440343 6.32 ENST00000283629.8
UBP1
upstream binding protein 1
chr3_+_136862200 6.08 ENST00000288986.6
ENST00000481752.6
ENST00000491539.5
ENST00000485096.5
NCK1
NCK adaptor protein 1
chr9_+_104094557 6.05 ENST00000374787.7
SMC2
structural maintenance of chromosomes 2
chr2_+_27663880 5.89 ENST00000618046.4
ENST00000613517.4
SLC4A1AP
solute carrier family 4 member 1 adaptor protein
chr2_+_12716893 5.86 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr6_+_27147094 5.63 ENST00000377459.3
H2AC12
H2A clustered histone 12
chr3_-_160565433 5.40 ENST00000483437.2
ENST00000678765.1
KPNA4
karyopherin subunit alpha 4
chr16_-_70289480 5.32 ENST00000261772.13
ENST00000675953.1
ENST00000675691.1
ENST00000675133.1
ENST00000674512.1
ENST00000675045.1
ENST00000675853.1
ENST00000565361.3
ENST00000674963.1
ENST00000674691.1
AARS1
alanyl-tRNA synthetase 1
chr19_-_38847423 5.28 ENST00000647557.1
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr2_+_201132872 5.24 ENST00000470178.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr2_-_241686712 5.08 ENST00000445261.5
DTYMK
deoxythymidylate kinase
chr5_-_126595237 5.07 ENST00000637206.1
ENST00000553117.5
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr5_+_151771884 4.88 ENST00000627077.2
ENST00000678976.1
ENST00000677408.1
ENST00000678070.1
ENST00000678964.1
ENST00000678925.1
ENST00000394123.7
ENST00000522761.6
ENST00000676827.1
G3BP1
G3BP stress granule assembly factor 1
chr22_-_30246739 4.88 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr5_+_151771943 4.85 ENST00000520177.6
ENST00000678854.1
ENST00000520006.2
ENST00000677105.1
ENST00000678101.1
ENST00000678910.1
ENST00000356245.8
ENST00000678646.1
ENST00000677433.1
ENST00000677369.1
ENST00000677284.1
ENST00000678564.1
G3BP1
G3BP stress granule assembly factor 1
chr10_-_99430617 4.84 ENST00000370508.7
GOT1
glutamic-oxaloacetic transaminase 1
chr1_-_202808464 4.71 ENST00000648469.1
ENST00000648338.1
ENST00000367264.7
ENST00000648473.1
ENST00000648056.1
ENST00000650368.1
KDM5B
lysine demethylase 5B
chr19_-_39391137 4.68 ENST00000595564.5
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr2_+_27663441 4.67 ENST00000326019.10
ENST00000613058.4
SLC4A1AP
solute carrier family 4 member 1 adaptor protein
chr19_-_10587219 4.62 ENST00000591240.5
ENST00000589684.5
ENST00000591676.1
ENST00000250244.11
ENST00000590923.5
AP1M2
adaptor related protein complex 1 subunit mu 2
chr17_+_75667390 4.58 ENST00000583536.5
SAP30BP
SAP30 binding protein
chr11_+_66616606 4.58 ENST00000393979.3
ENST00000409372.1
ENST00000310137.5
ENST00000443702.1
ENST00000409738.4
ENST00000412278.2
ENST00000500635.2
RBM14
RBM14-RBM4
RNA binding motif protein 14
RBM14-RBM4 readthrough
chr19_+_41264345 4.57 ENST00000378215.8
ENST00000392006.8
ENST00000617774.1
ENST00000602130.5
ENST00000617305.4
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U like 1
chr17_+_81683963 4.52 ENST00000676462.1
ENST00000679336.1
ENST00000678196.1
ENST00000677243.1
ENST00000677044.1
ENST00000677109.1
ENST00000677484.1
ENST00000678105.1
ENST00000677209.1
ENST00000329138.9
ENST00000677225.1
ENST00000678866.1
ENST00000676729.1
ENST00000572392.2
ENST00000577012.1
HGS
hepatocyte growth factor-regulated tyrosine kinase substrate
chr3_-_129439925 4.52 ENST00000429544.7
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr11_+_844406 4.45 ENST00000397404.5
TSPAN4
tetraspanin 4
chr6_+_151240368 4.43 ENST00000253332.5
AKAP12
A-kinase anchoring protein 12
chr12_+_20815672 4.43 ENST00000261196.6
ENST00000381541.7
ENST00000540229.1
SLCO1B3
SLCO1B3-SLCO1B7
solute carrier organic anion transporter family member 1B3
SLCO1B3-SLCO1B7 readthrough
chr2_+_201132928 4.42 ENST00000462763.5
CFLAR
CASP8 and FADD like apoptosis regulator
chrX_-_71254106 4.28 ENST00000373984.7
ENST00000314425.9
ENST00000373982.5
ZMYM3
zinc finger MYM-type containing 3
chr2_+_44168866 4.21 ENST00000282412.9
ENST00000409432.7
ENST00000378551.6
ENST00000345249.8
PPM1B
protein phosphatase, Mg2+/Mn2+ dependent 1B
chr5_-_179618032 4.18 ENST00000519033.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr17_+_75667315 4.08 ENST00000584667.6
ENST00000355423.7
SAP30BP
SAP30 binding protein
chr1_-_202808406 4.02 ENST00000650569.1
ENST00000367265.9
ENST00000649770.1
KDM5B
lysine demethylase 5B
chr12_+_21372899 3.88 ENST00000240652.8
ENST00000542023.1
ENST00000537593.1
IAPP
islet amyloid polypeptide
chr17_+_74987581 3.74 ENST00000337231.5
CDR2L
cerebellar degeneration related protein 2 like
chr19_+_14529580 3.66 ENST00000215567.10
TECR
trans-2,3-enoyl-CoA reductase
chr3_+_120742637 3.61 ENST00000484715.1
ENST00000469772.5
ENST00000492959.1
ENST00000283875.6
GTF2E1
general transcription factor IIE subunit 1
chr11_+_86244745 3.58 ENST00000528180.5
ENST00000263360.11
ENST00000672825.1
EED
embryonic ectoderm development
chr17_-_48545077 3.55 ENST00000330070.6
HOXB2
homeobox B2
chr16_+_16390834 3.55 ENST00000344087.4
NPIPA7
nuclear pore complex interacting protein family member A7
chr3_-_150546403 3.49 ENST00000239944.7
ENST00000491660.1
ENST00000487153.1
SERP1
stress associated endoplasmic reticulum protein 1
chr19_-_14529193 3.48 ENST00000596853.6
ENST00000676515.1
ENST00000678338.1
ENST00000595992.6
ENST00000677848.1
ENST00000677762.1
ENST00000678009.1
ENST00000596075.2
ENST00000601533.6
ENST00000396969.8
ENST00000598692.2
ENST00000678098.1
DNAJB1
DnaJ heat shock protein family (Hsp40) member B1
chr4_-_71784046 3.47 ENST00000513476.5
ENST00000273951.13
GC
GC vitamin D binding protein
chr8_-_90082871 3.44 ENST00000265431.7
CALB1
calbindin 1
chr2_-_189179754 3.39 ENST00000374866.9
ENST00000618828.1
COL5A2
collagen type V alpha 2 chain
chr19_-_49451793 3.35 ENST00000262265.10
PIH1D1
PIH1 domain containing 1
chr12_+_21501780 3.33 ENST00000229314.10
ENST00000542038.5
ENST00000540141.5
ENST00000631252.2
GOLT1B
golgi transport 1B
chr11_-_119095456 3.31 ENST00000530167.1
H2AX
H2A.X variant histone
chr3_+_136862254 3.24 ENST00000476286.1
ENST00000488930.5
NCK1
NCK adaptor protein 1
chr7_-_80919017 3.21 ENST00000265361.8
SEMA3C
semaphorin 3C
chrX_-_63785510 3.17 ENST00000437457.6
ENST00000374878.5
ENST00000623517.3
ARHGEF9
Cdc42 guanine nucleotide exchange factor 9
chr3_-_160565560 3.15 ENST00000334256.9
ENST00000676866.1
ENST00000469804.1
KPNA4
karyopherin subunit alpha 4
chr19_-_39391029 3.12 ENST00000221265.8
PAF1
PAF1 homolog, Paf1/RNA polymerase II complex component
chr16_+_69187125 3.12 ENST00000336278.8
SNTB2
syntrophin beta 2
chr6_-_26123910 3.07 ENST00000314332.5
ENST00000396984.1
H2BC4
H2B clustered histone 4
chr1_+_117060309 3.07 ENST00000369466.9
TTF2
transcription termination factor 2
chr19_+_15082211 3.02 ENST00000641398.1
OR1I1
olfactory receptor family 1 subfamily I member 1
chr17_+_21126947 3.00 ENST00000579303.5
DHRS7B
dehydrogenase/reductase 7B
chr6_+_151239951 2.99 ENST00000402676.7
AKAP12
A-kinase anchoring protein 12
chrX_-_103502853 2.84 ENST00000372633.1
RAB40A
RAB40A, member RAS oncogene family
chr9_-_6015607 2.83 ENST00000485372.1
ENST00000259569.6
ENST00000623170.1
RANBP6
RAN binding protein 6
chr16_+_15502266 2.80 ENST00000452191.6
BMERB1
bMERB domain containing 1
chr5_+_43602648 2.77 ENST00000505678.6
ENST00000512422.5
ENST00000264663.9
ENST00000670904.1
ENST00000653251.1
NNT
nicotinamide nucleotide transhydrogenase
chr6_+_26199509 2.66 ENST00000356530.5
H2BC7
H2B clustered histone 7
chr10_+_93757857 2.63 ENST00000478763.2
ENST00000371418.9
ENST00000630184.2
ENST00000630047.2
ENST00000637689.1
LGI1
leucine rich glioma inactivated 1
chr2_-_2326378 2.49 ENST00000647618.1
MYT1L
myelin transcription factor 1 like
chr10_+_93757831 2.44 ENST00000629035.2
LGI1
leucine rich glioma inactivated 1
chr11_+_95790459 2.36 ENST00000325486.9
ENST00000325542.10
ENST00000544522.5
ENST00000541365.5
CEP57
centrosomal protein 57
chrX_-_149505274 2.23 ENST00000428056.6
ENST00000340855.11
ENST00000370441.8
IDS
iduronate 2-sulfatase
chr5_+_126423363 2.18 ENST00000285689.8
GRAMD2B
GRAM domain containing 2B
chr6_+_26124161 2.18 ENST00000377791.4
ENST00000602637.1
H2AC6
H2A clustered histone 6
chr5_+_43603163 2.12 ENST00000660752.1
ENST00000654405.1
ENST00000344920.9
ENST00000657172.1
ENST00000512996.6
ENST00000671668.1
NNT
nicotinamide nucleotide transhydrogenase
chr7_-_102543849 2.08 ENST00000644544.1
UPK3BL2
uroplakin 3B like 2
chr12_+_14365661 1.98 ENST00000261168.9
ENST00000538511.5
ENST00000545723.1
ENST00000543189.5
ATF7IP
activating transcription factor 7 interacting protein
chr2_-_264024 1.94 ENST00000403712.6
ENST00000356150.10
ENST00000626873.2
ENST00000405430.5
SH3YL1
SH3 and SYLF domain containing 1
chrX_-_93673558 1.92 ENST00000475430.2
ENST00000373079.4
NAP1L3
nucleosome assembly protein 1 like 3
chr22_-_28741783 1.90 ENST00000439200.5
ENST00000405598.5
ENST00000398017.3
ENST00000649563.1
ENST00000650281.1
ENST00000425190.7
ENST00000404276.6
ENST00000650233.1
ENST00000348295.7
ENST00000382580.6
CHEK2
checkpoint kinase 2
chr5_+_55102635 1.89 ENST00000274306.7
GZMA
granzyme A
chr15_+_77420880 1.87 ENST00000336216.9
ENST00000558176.1
HMG20A
high mobility group 20A
chr6_+_26365215 1.83 ENST00000527422.5
ENST00000356386.6
ENST00000396948.5
BTN3A2
butyrophilin subfamily 3 member A2
chr5_-_83673544 1.74 ENST00000503117.1
ENST00000510978.5
HAPLN1
hyaluronan and proteoglycan link protein 1
chr12_-_46372763 1.68 ENST00000256689.10
SLC38A2
solute carrier family 38 member 2
chr4_-_139084289 1.52 ENST00000510408.5
ENST00000379549.7
ENST00000358635.7
ELF2
E74 like ETS transcription factor 2
chr3_+_158110052 1.49 ENST00000295930.7
ENST00000471994.5
ENST00000482822.3
ENST00000476899.6
ENST00000683899.1
ENST00000684604.1
ENST00000682164.1
ENST00000464171.5
ENST00000611884.5
ENST00000312179.10
ENST00000475278.6
RSRC1
arginine and serine rich coiled-coil 1
chr6_+_26365176 1.49 ENST00000377708.7
BTN3A2
butyrophilin subfamily 3 member A2
chr15_+_43777078 1.49 ENST00000381359.5
SERF2
small EDRK-rich factor 2
chrX_+_96684638 1.47 ENST00000355827.8
ENST00000373061.7
DIAPH2
diaphanous related formin 2
chr14_+_23469681 1.43 ENST00000408901.8
ENST00000397154.7
ENST00000555128.5
NGDN
neuroguidin
chr6_+_167291329 1.39 ENST00000366829.2
UNC93A
unc-93 homolog A
chr3_-_11604452 1.39 ENST00000413604.5
VGLL4
vestigial like family member 4
chr12_+_14365729 1.33 ENST00000536444.5
ATF7IP
activating transcription factor 7 interacting protein
chr6_-_82247697 1.30 ENST00000306270.12
ENST00000610980.4
IBTK
inhibitor of Bruton tyrosine kinase
chr2_+_201132958 1.29 ENST00000479953.6
ENST00000340870.6
CFLAR
CASP8 and FADD like apoptosis regulator
chr13_-_77919459 1.28 ENST00000643890.1
EDNRB
endothelin receptor type B
chr11_+_44095655 1.26 ENST00000684533.1
ENST00000683000.1
ENST00000395673.8
ENST00000682359.1
ENST00000533608.7
EXT2
exostosin glycosyltransferase 2
chr2_+_190880809 1.25 ENST00000320717.8
GLS
glutaminase
chr2_-_2326210 1.25 ENST00000647755.1
MYT1L
myelin transcription factor 1 like
chr11_+_44095710 1.19 ENST00000358681.8
ENST00000343631.4
ENST00000682711.1
EXT2
exostosin glycosyltransferase 2
chr22_-_26565362 1.18 ENST00000398110.6
TPST2
tyrosylprotein sulfotransferase 2
chr16_+_7510102 1.16 ENST00000682918.1
ENST00000683326.1
ENST00000570626.2
RBFOX1
RNA binding fox-1 homolog 1
chr11_-_69819410 1.15 ENST00000334134.4
FGF3
fibroblast growth factor 3
chr2_+_27032938 1.11 ENST00000238788.14
ENST00000404032.7
TMEM214
transmembrane protein 214
chr9_-_120914549 1.11 ENST00000546084.5
TRAF1
TNF receptor associated factor 1
chr2_-_153478753 1.10 ENST00000325926.4
RPRM
reprimo, TP53 dependent G2 arrest mediator homolog
chr19_+_9250930 1.07 ENST00000456448.3
OR7E24
olfactory receptor family 7 subfamily E member 24
chr3_-_169869833 1.04 ENST00000523069.1
ENST00000264676.9
ENST00000316428.10
LRRC31
leucine rich repeat containing 31
chr5_-_43313473 0.92 ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
chr1_+_205504592 0.85 ENST00000506784.5
ENST00000360066.6
CDK18
cyclin dependent kinase 18
chr17_+_59940908 0.80 ENST00000591035.1
ENSG00000267318.1
novel protein
chr5_-_95081482 0.66 ENST00000312216.12
ENST00000512425.5
ENST00000505208.5
ENST00000429576.6
ENST00000508509.5
ENST00000510732.5
MCTP1
multiple C2 and transmembrane domain containing 1
chr4_+_68815991 0.62 ENST00000265403.12
ENST00000458688.2
UGT2B10
UDP glucuronosyltransferase family 2 member B10
chr5_-_126595185 0.60 ENST00000510111.6
ENST00000635851.1
ENST00000637964.1
ENST00000413020.6
ENST00000637782.1
ENST00000409134.8
ENST00000637272.1
ENST00000636879.1
ENST00000636743.1
ENST00000636886.1
ENST00000509270.2
ALDH7A1
aldehyde dehydrogenase 7 family member A1
chr15_+_88635626 0.57 ENST00000379224.10
ISG20
interferon stimulated exonuclease gene 20
chr9_-_6565462 0.56 ENST00000638661.1
ENST00000640208.1
GLDC
glycine decarboxylase
chr9_-_21187671 0.56 ENST00000421715.2
IFNA4
interferon alpha 4
chr12_-_56221701 0.54 ENST00000615206.4
ENST00000549038.5
ENST00000552244.5
RNF41
ring finger protein 41
chr7_-_27102669 0.52 ENST00000222718.7
HOXA2
homeobox A2
chr3_+_123067016 0.43 ENST00000316218.12
PDIA5
protein disulfide isomerase family A member 5
chr16_+_19067893 0.39 ENST00000544894.6
ENST00000561858.5
COQ7
coenzyme Q7, hydroxylase
chr2_+_79185231 0.39 ENST00000466387.5
CTNNA2
catenin alpha 2
chr9_+_110668854 0.38 ENST00000189978.10
ENST00000374440.7
MUSK
muscle associated receptor tyrosine kinase
chr17_+_47896150 0.33 ENST00000642065.1
ENST00000613139.1
ENST00000637314.1
ENST00000637943.1
ENST00000376741.5
ENST00000635868.1
SP2
Sp2 transcription factor
chr19_-_15898057 0.31 ENST00000011989.11
ENST00000221700.11
CYP4F2
cytochrome P450 family 4 subfamily F member 2
chrX_-_73214793 0.22 ENST00000373517.4
NAP1L2
nucleosome assembly protein 1 like 2
chr7_+_134646845 0.16 ENST00000344924.8
BPGM
bisphosphoglycerate mutase
chr19_+_10718047 0.13 ENST00000585892.5
ENST00000355667.11
ENST00000389253.9
ENST00000359692.10
DNM2
dynamin 2
chr12_-_21501551 0.12 ENST00000421138.6
ENST00000539672.1
ENST00000542432.5
ENST00000444129.7
ENST00000536964.5
ENST00000536240.5
ENST00000396093.7
ENST00000314748.10
RECQL
RecQ like helicase
chr17_+_77185210 0.11 ENST00000431431.6
SEC14L1
SEC14 like lipid binding 1
chr11_+_95790659 0.10 ENST00000538658.5
CEP57
centrosomal protein 57
chr12_-_56221909 0.08 ENST00000394013.6
ENST00000345093.9
ENST00000551711.5
ENST00000552656.5
RNF41
ring finger protein 41
chr22_-_38794111 0.04 ENST00000406622.5
ENST00000216068.9
ENST00000406199.3
SUN2
DNAL4
Sad1 and UNC84 domain containing 2
dynein axonemal light chain 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
9.5 38.2 GO:0002188 translation reinitiation(GO:0002188)
7.3 21.8 GO:0006781 succinyl-CoA pathway(GO:0006781)
6.9 20.7 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
4.2 16.7 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
3.1 9.3 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
2.8 11.0 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
2.6 7.9 GO:2000176 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
2.4 26.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
2.1 6.4 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086) positive regulation of viral budding via host ESCRT complex(GO:1903774) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
1.9 5.7 GO:0031455 glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456)
1.7 8.7 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
1.7 19.1 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.6 4.9 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
1.6 24.4 GO:0000338 protein deneddylation(GO:0000338)
1.6 4.8 GO:0006533 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
1.6 22.4 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
1.5 7.7 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
1.5 5.9 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.4 7.0 GO:0070269 pyroptosis(GO:0070269)
1.3 17.4 GO:0090168 Golgi reassembly(GO:0090168)
1.3 6.7 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
1.3 6.6 GO:0031291 Ran protein signal transduction(GO:0031291)
1.3 7.9 GO:0006543 glutamine catabolic process(GO:0006543)
1.3 5.1 GO:0009138 pyrimidine nucleoside diphosphate metabolic process(GO:0009138)
1.2 11.6 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
1.1 3.3 GO:1903939 negative regulation of histone H3-K9 dimethylation(GO:1900110) regulation of TORC2 signaling(GO:1903939)
1.1 7.8 GO:0016584 nucleosome positioning(GO:0016584)
1.0 4.1 GO:0021569 rhombomere 3 development(GO:0021569)
1.0 9.1 GO:0010835 regulation of protein ADP-ribosylation(GO:0010835)
1.0 6.1 GO:0010032 meiotic chromosome condensation(GO:0010032)
1.0 10.0 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
1.0 4.9 GO:0006740 NADPH regeneration(GO:0006740)
0.9 11.3 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.9 8.9 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.9 11.6 GO:0045008 depyrimidination(GO:0045008)
0.9 27.5 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.7 3.4 GO:2000542 negative regulation of gastrulation(GO:2000542)
0.6 1.9 GO:0072428 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
0.6 4.2 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.5 6.5 GO:0051451 myoblast migration(GO:0051451)
0.5 3.2 GO:0003350 pulmonary myocardium development(GO:0003350)
0.5 8.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.5 3.6 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.4 3.4 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.4 2.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.4 10.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.4 1.2 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.4 4.6 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.4 11.4 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 9.8 GO:0043457 regulation of cellular respiration(GO:0043457)
0.3 6.7 GO:0019985 translesion synthesis(GO:0019985)
0.3 4.5 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
0.3 22.5 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 1.7 GO:0032328 alanine transport(GO:0032328)
0.2 3.5 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.2 16.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 3.7 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
0.2 1.9 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.2 3.5 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389) negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.2 0.6 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 8.4 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 9.2 GO:0043171 peptide catabolic process(GO:0043171)
0.2 20.3 GO:0006903 vesicle targeting(GO:0006903)
0.1 3.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 3.3 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 9.4 GO:0008542 visual learning(GO:0008542)
0.1 3.5 GO:0042359 vitamin D metabolic process(GO:0042359)
0.1 4.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 0.6 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 7.9 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.1 0.3 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.1 13.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 12.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 1.5 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 9.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 9.9 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.2 GO:2000617 positive regulation of histone H3-K9 acetylation(GO:2000617)
0.1 0.9 GO:0071372 cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.1 1.9 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 14.7 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 0.4 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.1 2.0 GO:0048665 neuron fate specification(GO:0048665)
0.1 0.6 GO:1901525 negative regulation of macromitophagy(GO:1901525)
0.1 1.9 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.1 1.5 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 1.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 2.1 GO:1901661 quinone metabolic process(GO:1901661)
0.0 2.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 3.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 4.1 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.6 GO:0002323 natural killer cell activation involved in immune response(GO:0002323)
0.0 6.3 GO:0019079 viral genome replication(GO:0019079)
0.0 1.2 GO:0055026 negative regulation of cardiac muscle tissue development(GO:0055026)
0.0 1.4 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.2 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.0 5.1 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 4.6 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 1.7 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 3.3 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.1 GO:0039536 choline transport(GO:0015871) negative regulation of RIG-I signaling pathway(GO:0039536)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
2.6 7.7 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
1.5 27.5 GO:0005662 DNA replication factor A complex(GO:0005662)
1.5 4.5 GO:0033565 ESCRT-0 complex(GO:0033565)
1.3 11.6 GO:0042382 paraspeckles(GO:0042382)
1.3 16.5 GO:0002199 zona pellucida receptor complex(GO:0002199)
1.2 14.2 GO:0071203 WASH complex(GO:0071203)
1.1 3.4 GO:0005588 collagen type V trimer(GO:0005588)
1.1 10.0 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
1.0 3.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.9 19.1 GO:0097342 ripoptosome(GO:0097342)
0.9 6.1 GO:0000796 condensin complex(GO:0000796)
0.8 10.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.7 8.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.7 7.8 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.7 6.4 GO:0000813 ESCRT I complex(GO:0000813)
0.6 2.5 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.5 9.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 24.4 GO:0008180 COP9 signalosome(GO:0008180)
0.4 3.3 GO:0070761 pre-snoRNP complex(GO:0070761)
0.4 3.6 GO:0001739 sex chromatin(GO:0001739)
0.4 3.6 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 22.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 7.9 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 7.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.3 26.9 GO:0000118 histone deacetylase complex(GO:0000118)
0.2 20.7 GO:0014704 intercalated disc(GO:0014704)
0.2 13.0 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.2 9.7 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 7.9 GO:0005844 polysome(GO:0005844)
0.1 36.1 GO:0043209 myelin sheath(GO:0043209)
0.1 0.6 GO:0005960 glycine cleavage complex(GO:0005960)
0.1 4.6 GO:0016592 mediator complex(GO:0016592)
0.1 25.6 GO:0005681 spliceosomal complex(GO:0005681)
0.1 8.6 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.1 17.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 10.4 GO:0005776 autophagosome(GO:0005776)
0.1 16.9 GO:0042383 sarcolemma(GO:0042383)
0.1 8.4 GO:0072686 mitotic spindle(GO:0072686)
0.1 4.6 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 4.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.3 GO:0043679 axon terminus(GO:0043679)
0.0 5.1 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 9.8 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.4 GO:0032040 small-subunit processome(GO:0032040)
0.0 1.9 GO:0001772 immunological synapse(GO:0001772)
0.0 6.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.0 5.3 GO:0035770 ribonucleoprotein granule(GO:0035770)
0.0 14.4 GO:0016607 nuclear speck(GO:0016607)
0.0 10.4 GO:0031965 nuclear membrane(GO:0031965)
0.0 7.4 GO:0005938 cell cortex(GO:0005938)
0.0 2.8 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.5 GO:0016605 PML body(GO:0016605)
0.0 2.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 10.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 11.2 GO:0005694 chromosome(GO:0005694)
0.0 4.6 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 3.3 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 21.8 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
2.6 23.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
2.6 20.7 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
2.3 11.6 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
2.2 6.7 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
1.7 8.7 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
1.7 5.1 GO:0009041 uridylate kinase activity(GO:0009041)
1.6 4.8 GO:0080130 L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.6 9.3 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
1.5 7.7 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
1.3 7.9 GO:0004359 glutaminase activity(GO:0004359)
1.2 15.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.2 3.5 GO:1902271 D3 vitamins binding(GO:1902271)
1.1 8.9 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
1.1 6.3 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
1.0 15.6 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.9 3.7 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.9 3.4 GO:0005499 vitamin D binding(GO:0005499)
0.8 2.5 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.7 22.9 GO:0042288 MHC class I protein binding(GO:0042288)
0.6 19.1 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.5 5.3 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 18.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.5 3.3 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
0.5 9.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.5 6.4 GO:0046790 virion binding(GO:0046790)
0.5 10.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.4 4.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.4 28.7 GO:0003743 translation initiation factor activity(GO:0003743)
0.4 7.4 GO:0008179 adenylate cyclase binding(GO:0008179)
0.4 1.2 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.4 18.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.4 12.1 GO:0008266 poly(U) RNA binding(GO:0008266)
0.4 9.2 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 5.9 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.3 7.9 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 0.9 GO:0004421 hydroxymethylglutaryl-CoA synthase activity(GO:0004421)
0.3 6.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 4.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 3.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.2 7.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 5.7 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 9.9 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 0.6 GO:0005128 erythropoietin receptor binding(GO:0005128) interleukin-3 receptor binding(GO:0005135)
0.2 3.2 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 0.6 GO:0008859 exoribonuclease II activity(GO:0008859)
0.2 8.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.2 19.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 10.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 8.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 1.3 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 11.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 2.2 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.1 0.3 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.1 3.5 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 7.0 GO:0016836 hydro-lyase activity(GO:0016836)
0.1 9.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 4.2 GO:0030145 manganese ion binding(GO:0030145)
0.1 20.8 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 19.1 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 4.9 GO:0051287 NAD binding(GO:0051287)
0.1 32.9 GO:0045296 cadherin binding(GO:0045296)
0.1 4.6 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.1 GO:0031996 thioesterase binding(GO:0031996)
0.1 10.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.9 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 4.1 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 15.9 GO:0003682 chromatin binding(GO:0003682)
0.0 1.2 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 3.4 GO:0046332 SMAD binding(GO:0046332)
0.0 0.6 GO:0016594 glycine binding(GO:0016594)
0.0 0.2 GO:0004082 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0 0.4 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037)
0.0 0.1 GO:0039552 RIG-I binding(GO:0039552)
0.0 3.6 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.1 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0 4.2 GO:0008134 transcription factor binding(GO:0008134)
0.0 8.8 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.6 19.1 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.6 33.0 PID ATR PATHWAY ATR signaling pathway
0.4 15.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.3 17.0 PID AURORA B PATHWAY Aurora B signaling
0.2 16.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 9.3 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 10.9 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 10.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.2 6.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.2 11.6 PID P53 REGULATION PATHWAY p53 pathway
0.1 10.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 3.2 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.4 NABA COLLAGENS Genes encoding collagen proteins
0.0 2.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.1 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0 4.9 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.9 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 3.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 0.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 27.5 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.4 45.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
1.0 26.6 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.7 17.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.6 19.1 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.6 11.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.6 6.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.6 11.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.6 8.9 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.4 6.6 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 26.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.4 9.3 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 10.0 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.3 4.6 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.3 7.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.3 4.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 4.3 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.2 5.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.6 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 21.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 12.8 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.7 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 1.9 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.1 3.5 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 2.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 3.9 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 11.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 18.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 3.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.1 3.4 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 3.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway