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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PBX2
Z-value: 0.32
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Transcription factors associated with PBX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX2 | hg38_v1_chr6_-_32190170_32190214 | -0.12 | 7.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 8.3 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.4 | 4.2 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.3 | 3.9 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.1 | 3.3 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.7 | 2.7 | GO:1900186 | negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021) |
| 0.0 | 2.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.4 | 2.5 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) |
| 0.2 | 2.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.6 | 1.9 | GO:0003245 | cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) |
| 0.5 | 1.9 | GO:0009256 | 10-formyltetrahydrofolate metabolic process(GO:0009256) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 2.7 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 2.7 | GO:0005776 | autophagosome(GO:0005776) |
| 0.1 | 2.5 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 2.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 1.9 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 1.1 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 1.0 | GO:1990726 | Lsm1-7-Pat1 complex(GO:1990726) |
| 0.0 | 1.0 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.8 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.1 | 4.2 | GO:0015020 | retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020) |
| 0.8 | 3.9 | GO:0008263 | pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263) |
| 0.1 | 3.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 2.7 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.7 | 2.1 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.5 | 1.9 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488) |
| 0.2 | 1.9 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.0 | 1.9 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.8 | GO:0055106 | ubiquitin-protein transferase regulator activity(GO:0055106) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 2.5 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 1.9 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 1.4 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 1.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 0.5 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.2 | 3.9 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.0 | 3.3 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.9 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 1.4 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 1.1 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 1.0 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.0 | 0.8 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 0.6 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.0 | 0.5 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |