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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PBX2

Z-value: 0.32

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Transcription factors associated with PBX2

Gene Symbol Gene ID Gene Info
PBX2
ENSG00000204304.12 PBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PBX2hg38_v1_chr6_-_32190170_32190214-0.127.4e-02Click!

Activity profile of PBX2 motif

Sorted Z-values of PBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PBX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_+_120604199 4.33 ENST00000371315.3
MCTS1
MCTS1 re-initiation and release factor
chrX_+_120604084 4.01 ENST00000371317.10
MCTS1
MCTS1 re-initiation and release factor
chr12_+_53441724 2.93 ENST00000551003.5
ENST00000429243.7
ENST00000549068.5
ENST00000549740.5
ENST00000546581.5
ENST00000549581.5
ENST00000547368.5
ENST00000379786.8
ENST00000551945.5
ENST00000547717.1
PRR13
ENSG00000257379.1
proline rich 13
novel transcript
chr7_+_142791635 2.73 ENST00000633705.1
TRBC1
T cell receptor beta constant 1
chrX_+_56563569 2.69 ENST00000338222.7
UBQLN2
ubiquilin 2
chr14_-_55191534 2.48 ENST00000395425.6
ENST00000247191.7
DLGAP5
DLG associated protein 5
chr2_+_233693659 2.28 ENST00000406651.1
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr3_-_129440007 2.00 ENST00000503197.5
ENST00000249910.5
ENST00000507208.1
ENST00000393278.6
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr2_+_233692881 1.95 ENST00000305139.11
UGT1A6
UDP glucuronosyltransferase family 1 member A6
chr14_+_64388296 1.92 ENST00000554739.5
ENST00000554768.6
ENST00000652179.1
ENST00000652337.1
ENST00000557370.3
MTHFD1
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
chr3_-_129439925 1.91 ENST00000429544.7
MBD4
methyl-CpG binding domain 4, DNA glycosylase
chr1_+_101237009 1.90 ENST00000305352.7
S1PR1
sphingosine-1-phosphate receptor 1
chr2_-_264024 1.86 ENST00000403712.6
ENST00000356150.10
ENST00000626873.2
ENST00000405430.5
SH3YL1
SH3 and SYLF domain containing 1
chr2_+_12716893 1.84 ENST00000381465.2
ENST00000155926.9
TRIB2
tribbles pseudokinase 2
chr12_-_27972725 1.70 ENST00000545234.6
PTHLH
parathyroid hormone like hormone
chr12_-_27971970 1.60 ENST00000395872.5
ENST00000201015.8
PTHLH
parathyroid hormone like hormone
chr22_-_30246739 1.49 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr17_-_30824665 1.45 ENST00000324238.7
CRLF3
cytokine receptor like factor 3
chr3_+_190615308 1.40 ENST00000412080.1
IL1RAP
interleukin 1 receptor accessory protein
chr11_-_62665169 1.38 ENST00000528405.1
ENST00000525675.1
ENST00000524958.6
ENSG00000255432.1
C11orf98
novel protein
chromosome 11 open reading frame 98
chr2_+_20447065 1.15 ENST00000272233.6
RHOB
ras homolog family member B
chrM_+_12329 1.00 ENST00000361567.2
MT-ND5
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
chr7_-_32490361 0.95 ENST00000410044.5
ENST00000450169.7
ENST00000409987.5
ENST00000409782.5
LSM5
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
chr7_-_151520080 0.80 ENST00000496004.5
RHEB
Ras homolog, mTORC1 binding
chr6_+_159790448 0.78 ENST00000367034.5
MRPL18
mitochondrial ribosomal protein L18
chr2_+_44168866 0.78 ENST00000282412.9
ENST00000409432.7
ENST00000378551.6
ENST00000345249.8
PPM1B
protein phosphatase, Mg2+/Mn2+ dependent 1B
chr10_+_122560751 0.74 ENST00000338354.10
ENST00000664692.1
ENST00000653442.1
ENST00000664974.1
DMBT1
deleted in malignant brain tumors 1
chr10_+_122560639 0.69 ENST00000344338.7
ENST00000330163.8
ENST00000652446.2
ENST00000666315.1
ENST00000368955.7
ENST00000368909.7
ENST00000368956.6
ENST00000619379.1
DMBT1
deleted in malignant brain tumors 1
chr10_+_122560679 0.68 ENST00000657942.1
DMBT1
deleted in malignant brain tumors 1
chr14_-_23155302 0.60 ENST00000529705.6
SLC7A8
solute carrier family 7 member 8
chr17_+_8288637 0.56 ENST00000407006.8
ENST00000226105.11
ENST00000580434.5
ENST00000439238.3
RANGRF
RAN guanine nucleotide release factor
chr15_+_67125707 0.48 ENST00000540846.6
SMAD3
SMAD family member 3
chr5_+_55024250 0.42 ENST00000231009.3
GZMK
granzyme K
chr14_+_22516273 0.41 ENST00000390510.1
TRAJ27
T cell receptor alpha joining 27
chr8_-_6563409 0.37 ENST00000325203.9
ANGPT2
angiopoietin 2
chr2_+_203867943 0.33 ENST00000295854.10
ENST00000487393.1
ENST00000472206.1
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr11_-_55936400 0.28 ENST00000301532.3
OR5I1
olfactory receptor family 5 subfamily I member 1
chr4_+_37960397 0.26 ENST00000504686.2
PTTG2
pituitary tumor-transforming 2
chrX_+_46837034 0.25 ENST00000218340.4
RP2
RP2 activator of ARL3 GTPase
chr7_-_113087720 0.25 ENST00000297146.7
GPR85
G protein-coupled receptor 85
chr17_-_1229706 0.23 ENST00000574139.7
ABR
ABR activator of RhoGEF and GTPase
chr8_+_109086585 0.21 ENST00000518632.2
TRHR
thyrotropin releasing hormone receptor
chr2_+_203867764 0.20 ENST00000648405.2
CTLA4
cytotoxic T-lymphocyte associated protein 4
chr16_+_1078781 0.12 ENST00000293897.5
SSTR5
somatostatin receptor 5
chr12_+_41437680 0.10 ENST00000649474.1
ENST00000539469.6
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr14_+_58298497 0.09 ENST00000348476.7
ENST00000355431.8
ENST00000395168.7
ARID4A
AT-rich interaction domain 4A
chrX_+_1615049 0.09 ENST00000381241.9
ASMT
acetylserotonin O-methyltransferase
chr3_-_52830664 0.06 ENST00000266041.9
ENST00000406595.5
ENST00000485816.5
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.3 GO:0002188 translation reinitiation(GO:0002188)
0.7 2.7 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.6 1.9 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245)
0.5 1.5 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.5 1.9 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.5 1.8 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.4 2.5 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.4 4.2 GO:0052697 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.3 3.9 GO:0045008 depyrimidination(GO:0045008)
0.3 0.8 GO:0035928 rRNA import into mitochondrion(GO:0035928)
0.2 1.4 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.2 2.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.6 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
0.1 0.4 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.1 0.8 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.1 3.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.5 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 0.5 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.1 0.8 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 0.2 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.0 1.9 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 1.1 GO:0061154 endothelial tube morphogenesis(GO:0061154)
0.0 2.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.1 GO:0097368 histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.0 1.0 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0 0.6 GO:0015695 organic cation transport(GO:0015695)
0.0 1.4 GO:0046427 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.0 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 2.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 8.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 2.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 0.3 GO:1990075 periciliary membrane compartment(GO:1990075)
0.1 0.5 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.1 2.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.7 GO:0005776 autophagosome(GO:0005776)
0.0 0.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 1.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 1.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0098636 protein complex involved in cell adhesion(GO:0098636)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.9 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
0.7 2.1 GO:0035375 zymogen binding(GO:0035375)
0.5 1.9 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.2 1.4 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.2 1.9 GO:0046625 sphingolipid binding(GO:0046625)
0.1 1.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 8.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.8 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 4.2 GO:0015020 retinoic acid binding(GO:0001972) glucuronosyltransferase activity(GO:0015020)
0.1 0.5 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.1 3.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 0.8 GO:0008097 5S rRNA binding(GO:0008097)
0.0 2.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.6 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.3 GO:0005549 odorant binding(GO:0005549)
0.0 0.1 GO:0004994 somatostatin receptor activity(GO:0004994)
0.0 1.9 GO:0019003 GDP binding(GO:0019003)
0.0 1.0 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.1 GO:0008172 S-methyltransferase activity(GO:0008172)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 1.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 2.5 PID AURORA A PATHWAY Aurora A signaling
0.0 1.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.5 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 0.5 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 4.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.8 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 3.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 1.9 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.5 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.0 0.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.0 0.4 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling