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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PBX3
Z-value: 1.60
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Transcription factors associated with PBX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PBX3 | hg38_v1_chr9_+_125748175_125748199, hg38_v1_chr9_+_125747345_125747380 | -0.29 | 9.8e-06 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PBX3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_12551426 Show fit | 46.33 |
ENST00000416136.1
ENST00000339282.12 ENST00000596193.1 ENST00000428311.1 |
zinc finger protein 564 novel zinc finger protein |
|
| chr16_-_30021288 Show fit | 38.15 |
ENST00000574405.5
|
double C2 domain alpha |
|
| chr19_+_21020675 Show fit | 37.65 |
ENST00000595401.1
|
zinc finger protein 430 |
|
| chr3_+_111998915 Show fit | 34.40 |
ENST00000478951.6
|
transgelin 3 |
|
| chr19_-_12484773 Show fit | 32.60 |
ENST00000397732.8
|
zinc finger protein 709 |
|
| chr3_+_111998739 Show fit | 32.58 |
ENST00000393917.6
ENST00000273368.8 |
transgelin 3 |
|
| chrX_+_103776493 Show fit | 32.43 |
ENST00000433491.5
ENST00000612423.4 ENST00000443502.5 |
proteolipid protein 1 |
|
| chrX_+_103776831 Show fit | 32.38 |
ENST00000621218.5
ENST00000619236.1 |
proteolipid protein 1 |
|
| chr16_-_53503192 Show fit | 29.83 |
ENST00000568596.5
ENST00000394657.12 ENST00000570004.5 ENST00000564497.1 ENST00000300245.8 |
AKT interacting protein |
|
| chr3_+_111999189 Show fit | 28.86 |
ENST00000455401.6
|
transgelin 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 64.8 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.8 | 49.8 | GO:0042417 | dopamine metabolic process(GO:0042417) |
| 0.1 | 44.4 | GO:0007417 | central nervous system development(GO:0007417) |
| 3.1 | 40.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.9 | 38.2 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 0.4 | 37.6 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 4.0 | 35.9 | GO:0060075 | regulation of resting membrane potential(GO:0060075) |
| 1.4 | 33.1 | GO:0006895 | Golgi to endosome transport(GO:0006895) |
| 0.7 | 32.4 | GO:0045022 | early endosome to late endosome transport(GO:0045022) |
| 0.5 | 30.5 | GO:0021762 | substantia nigra development(GO:0021762) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 125.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 3.1 | 40.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 5.1 | 35.9 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 4.0 | 32.2 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 7.5 | 29.8 | GO:0070695 | FHF complex(GO:0070695) |
| 0.2 | 29.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 28.1 | GO:0016234 | inclusion body(GO:0016234) |
| 0.1 | 27.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 25.8 | GO:0005604 | basement membrane(GO:0005604) |
| 2.3 | 25.0 | GO:0070775 | H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 319.8 | GO:0046872 | metal ion binding(GO:0046872) |
| 0.4 | 90.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 71.0 | GO:0008270 | zinc ion binding(GO:0008270) |
| 5.4 | 64.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.5 | 45.7 | GO:0030276 | clathrin binding(GO:0030276) |
| 3.0 | 45.6 | GO:1903136 | cuprous ion binding(GO:1903136) |
| 0.3 | 40.1 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.4 | 37.7 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 2.8 | 35.9 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) steroid hormone binding(GO:1990239) |
| 0.6 | 35.6 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 40.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.7 | 36.7 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.4 | 36.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 1.0 | 24.6 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.1 | 21.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 20.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 19.2 | PID FGF PATHWAY | FGF signaling pathway |
| 0.3 | 17.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 17.5 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.5 | 15.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 242.6 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.8 | 42.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 1.5 | 40.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 1.2 | 31.1 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.4 | 28.6 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.5 | 27.7 | REACTOME SIGNAL TRANSDUCTION BY L1 | Genes involved in Signal transduction by L1 |
| 0.5 | 25.6 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 1.1 | 25.2 | REACTOME ACYL CHAIN REMODELLING OF PE | Genes involved in Acyl chain remodelling of PE |
| 2.4 | 21.8 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.3 | 17.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |