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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PDX1
Z-value: 0.82
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Transcription factors associated with PDX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PDX1 | hg38_v1_chr13_+_27919993_27920031 | -0.51 | 1.1e-15 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PDX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr15_+_74788542 Show fit | 38.10 |
ENST00000567571.5
|
C-terminal Src kinase |
|
| chr13_+_30427950 Show fit | 23.45 |
ENST00000436446.1
|
ubiquitin conjugating enzyme E2 L5 |
|
| chr13_-_46142834 Show fit | 22.28 |
ENST00000674665.1
|
lymphocyte cytosolic protein 1 |
|
| chr15_-_55270874 Show fit | 21.20 |
ENST00000567380.5
ENST00000565972.5 ENST00000569493.5 |
RAB27A, member RAS oncogene family |
|
| chr15_-_55270280 Show fit | 19.90 |
ENST00000564609.5
|
RAB27A, member RAS oncogene family |
|
| chr6_+_106360668 Show fit | 19.65 |
ENST00000633556.3
|
crystallin beta-gamma domain containing 1 |
|
| chr12_+_28257195 Show fit | 19.39 |
ENST00000381259.5
|
coiled-coil domain containing 91 |
|
| chr7_+_117020191 Show fit | 16.73 |
ENST00000434836.5
ENST00000393443.5 ENST00000465133.5 ENST00000477742.5 ENST00000393444.7 ENST00000393447.8 |
suppression of tumorigenicity 7 |
|
| chr15_-_55270383 Show fit | 16.54 |
ENST00000396307.6
|
RAB27A, member RAS oncogene family |
|
| chr4_-_102828022 Show fit | 16.20 |
ENST00000502690.5
|
ubiquitin conjugating enzyme E2 D3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 57.6 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 1.1 | 51.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 6.3 | 38.1 | GO:0010989 | negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997) |
| 1.1 | 22.3 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.2 | 21.1 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 1.6 | 19.4 | GO:0090160 | Golgi to lysosome transport(GO:0090160) |
| 0.6 | 17.5 | GO:0072663 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.5 | 14.4 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 4.3 | 12.9 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.4 | 12.9 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 63.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 3.4 | 44.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 43.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.1 | 35.2 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.9 | 22.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.1 | 18.5 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 16.8 | GO:0005819 | spindle(GO:0005819) |
| 0.9 | 16.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 15.7 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.8 | 12.1 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 57.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.1 | 51.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.4 | 38.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 20.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 18.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 17.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.3 | 17.5 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.3 | 14.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.4 | 14.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 14.3 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 52.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.0 | 51.9 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.4 | 20.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.5 | 16.9 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 14.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 14.3 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 14.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 10.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.1 | 9.7 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
| 0.2 | 9.0 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 55.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 1.4 | 51.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 2.1 | 51.0 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.4 | 18.5 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.1 | 12.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 11.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.4 | 10.4 | REACTOME INTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Intrinsic Pathway for Apoptosis |
| 0.2 | 9.7 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.4 | 8.8 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.1 | 8.6 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |