ISMARA results: PDX1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PDX1

Z-value: 0.82

Motif logo

Transcription factors associated with PDX1

Gene Symbol	Gene ID	Gene Info
PDX1 Ensembl NCBI GeneCards UniProt	ENSG00000139515.6	PDX1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PDX1	hg38_v1_chr13_+_27919993_27920031	-0.51	1.1e-15	Click!

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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View png image

Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr15_+_74788542 Show fit	38.10	ENST00000567571.5	CSK Ensembl NCBI GeneCards UniProt Show fit	C-terminal Src kinase
chr13_+_30427950 Show fit	23.45	ENST00000436446.1	UBE2L5 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 L5
chr13_-_46142834 Show fit	22.28	ENST00000674665.1	LCP1 Ensembl NCBI GeneCards UniProt Show fit	lymphocyte cytosolic protein 1
chr15_-_55270874 Show fit	21.20	ENST00000567380.5 ENST00000565972.5 ENST00000569493.5	RAB27A Ensembl NCBI GeneCards UniProt Show fit	RAB27A, member RAS oncogene family
chr15_-_55270280 Show fit	19.90	ENST00000564609.5	RAB27A Ensembl NCBI GeneCards UniProt Show fit	RAB27A, member RAS oncogene family
chr6_+_106360668 Show fit	19.65	ENST00000633556.3	CRYBG1 Ensembl NCBI GeneCards UniProt Show fit	crystallin beta-gamma domain containing 1
chr12_+_28257195 Show fit	19.39	ENST00000381259.5	CCDC91 Ensembl NCBI GeneCards UniProt Show fit	coiled-coil domain containing 91
chr7_+_117020191 Show fit	16.73	ENST00000434836.5 ENST00000393443.5 ENST00000465133.5 ENST00000477742.5 ENST00000393444.7 ENST00000393447.8	ST7 Ensembl NCBI GeneCards UniProt Show fit	suppression of tumorigenicity 7
chr15_-_55270383 Show fit	16.54	ENST00000396307.6	RAB27A Ensembl NCBI GeneCards UniProt Show fit	RAB27A, member RAS oncogene family
chr4_-_102828022 Show fit	16.20	ENST00000502690.5	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr4_-_102828048 Show fit	15.10	ENST00000508249.1	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chrX_-_20218941 Show fit	14.38	ENST00000457145.6	RPS6KA3 Ensembl NCBI GeneCards UniProt Show fit	ribosomal protein S6 kinase A3
chr13_-_41019289 Show fit	12.91	ENST00000239882.7	ELF1 Ensembl NCBI GeneCards UniProt Show fit	E74 like ETS transcription factor 1
chr1_+_198638968 Show fit	12.89	ENST00000348564.11 ENST00000530727.5 ENST00000442510.8 ENST00000645247.1 ENST00000367367.8 ENST00000367364.5 ENST00000413409.6	PTPRC Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase receptor type C
chr12_+_49750598 Show fit	12.41	ENST00000552370.5	TMBIM6 Ensembl NCBI GeneCards UniProt Show fit	transmembrane BAX inhibitor motif containing 6
chr1_-_244862381 Show fit	12.12	ENST00000640001.1 ENST00000639628.1	HNRNPU Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein U
chr18_+_3447562 Show fit	11.26	ENST00000618001.4	TGIF1 Ensembl NCBI GeneCards UniProt Show fit	TGFB induced factor homeobox 1
chr5_-_135399863 Show fit	10.98	ENST00000510038.1 ENST00000304332.8	MACROH2A1 Ensembl NCBI GeneCards UniProt Show fit	macroH2A.1 histone
chr19_+_1266653 Show fit	10.66	ENST00000586472.5 ENST00000589266.5	CIRBP Ensembl NCBI GeneCards UniProt Show fit	cold inducible RNA binding protein
chr10_+_110964125 Show fit	10.58	ENST00000265277.9	SHOC2 Ensembl NCBI GeneCards UniProt Show fit	SHOC2 leucine rich repeat scaffold protein
chr17_+_44957907 Show fit	10.41	ENST00000678938.1	NMT1 Ensembl NCBI GeneCards UniProt Show fit	N-myristoyltransferase 1
chr5_-_143400716 Show fit	9.66	ENST00000424646.6 ENST00000652686.1	NR3C1 Ensembl NCBI GeneCards UniProt Show fit	nuclear receptor subfamily 3 group C member 1
chr5_+_136059151 Show fit	9.47	ENST00000503087.1	TGFBI Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta induced
chr5_+_136058849 Show fit	9.08	ENST00000508076.5	TGFBI Ensembl NCBI GeneCards UniProt Show fit	transforming growth factor beta induced
chr6_+_63521738 Show fit	8.98	ENST00000648894.1 ENST00000639568.2	PTP4A1 Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase 4A1
chr18_+_59899988 Show fit	8.83	ENST00000316660.7 ENST00000269518.9	PMAIP1 Ensembl NCBI GeneCards UniProt Show fit	phorbol-12-myristate-13-acetate-induced protein 1
chr11_-_11353241 Show fit	8.66	ENST00000528848.3	CSNK2A3 Ensembl NCBI GeneCards UniProt Show fit	casein kinase 2 alpha 3
chr20_+_1135217 Show fit	8.64	ENST00000381898.5	PSMF1 Ensembl NCBI GeneCards UniProt Show fit	proteasome inhibitor subunit 1
chr8_-_42377227 Show fit	8.41	ENST00000220812.3	DKK4 Ensembl NCBI GeneCards UniProt Show fit	dickkopf WNT signaling pathway inhibitor 4
chr1_+_174875505 Show fit	8.36	ENST00000486220.5	RABGAP1L Ensembl NCBI GeneCards UniProt Show fit	RAB GTPase activating protein 1 like
chr6_-_25042003 Show fit	7.84	ENST00000510784.8	RIPOR2 Ensembl NCBI GeneCards UniProt Show fit	RHO family interacting cell polarization regulator 2
chr2_+_90021567 Show fit	7.60	ENST00000436451.2	IGKV6D-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6D-21 (non-functional)
chr18_-_36129305 Show fit	7.49	ENST00000269187.10 ENST00000590986.5 ENST00000440549.6	SLC39A6 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 39 member 6
chr4_-_102827723 Show fit	7.27	ENST00000349311.12	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr1_+_159010002 Show fit	6.97	ENST00000359709.7	IFI16 Ensembl NCBI GeneCards UniProt Show fit	interferon gamma inducible protein 16
chr15_+_80059635 Show fit	6.87	ENST00000559157.5	ZFAND6 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 6
chr17_-_79950828 Show fit	6.80	ENST00000572862.5 ENST00000573782.5 ENST00000574427.1 ENST00000570373.5 ENST00000340848.11 ENST00000576768.5	TBC1D16 Ensembl NCBI GeneCards UniProt Show fit	TBC1 domain family member 16
chr4_-_102828159 Show fit	6.79	ENST00000394803.9	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr7_-_25228485 Show fit	6.77	ENST00000222674.2	NPVF Ensembl NCBI GeneCards UniProt Show fit	neuropeptide VF precursor
chr2_-_89160329 Show fit	6.73	ENST00000390256.2	IGKV6-21 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 6-21 (non-functional)
chr12_+_49227874 Show fit	6.62	ENST00000541364.5	TUBA1C Ensembl NCBI GeneCards UniProt Show fit	tubulin alpha 1c
chr4_-_102827948 Show fit	6.56	ENST00000394804.6 ENST00000394801.8	UBE2D3 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin conjugating enzyme E2 D3
chr15_+_80059568 Show fit	6.36	ENST00000613266.4 ENST00000561060.5	ZFAND6 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 6
chr8_+_10095704 Show fit	6.34	ENST00000382490.9	MSRA Ensembl NCBI GeneCards UniProt Show fit	methionine sulfoxide reductase A
chr18_+_58221535 Show fit	6.28	ENST00000431212.6 ENST00000586268.5 ENST00000587190.5	NEDD4L Ensembl NCBI GeneCards UniProt Show fit	NEDD4 like E3 ubiquitin protein ligase
chr18_-_36798482 Show fit	6.10	ENST00000590258.2	TPGS2 Ensembl NCBI GeneCards UniProt Show fit	tubulin polyglutamylase complex subunit 2
chr8_+_10095551 Show fit	6.02	ENST00000522907.5 ENST00000528246.5	MSRA Ensembl NCBI GeneCards UniProt Show fit	methionine sulfoxide reductase A
chr9_-_134068012 Show fit	5.98	ENST00000303407.12	BRD3 Ensembl NCBI GeneCards UniProt Show fit	bromodomain containing 3
chr14_+_71586261 Show fit	5.93	ENST00000358550.6	SIPA1L1 Ensembl NCBI GeneCards UniProt Show fit	signal induced proliferation associated 1 like 1
chr16_-_30445865 Show fit	5.83	ENST00000478753.5	SEPHS2 Ensembl NCBI GeneCards UniProt Show fit	selenophosphate synthetase 2
chr19_+_12938598 Show fit	5.66	ENST00000586760.2 ENST00000316448.10 ENST00000588454.6	CALR Ensembl NCBI GeneCards UniProt Show fit	calreticulin
chr3_+_136930469 Show fit	5.56	ENST00000469404.1 ENST00000467911.1	NCK1 Ensembl NCBI GeneCards UniProt Show fit	NCK adaptor protein 1
chr7_+_101218146 Show fit	5.53	ENST00000305105.3	ZNHIT1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger HIT-type containing 1
chr4_+_106316531 Show fit	5.51	ENST00000684504.1 ENST00000442366.6 ENST00000672337.1 ENST00000394701.6 ENST00000672341.1 ENST00000671868.1 ENST00000673123.1 ENST00000672328.1 ENST00000672911.1 ENST00000672285.1	AIMP1 Ensembl NCBI GeneCards UniProt Show fit	aminoacyl tRNA synthetase complex interacting multifunctional protein 1
chr10_+_11005301 Show fit	5.45	ENST00000416382.6 ENST00000631460.1 ENST00000631816.1	CELF2 Ensembl NCBI GeneCards UniProt Show fit	CUGBP Elav-like family member 2
chr1_+_67685170 Show fit	5.32	ENST00000370985.4 ENST00000370986.9 ENST00000650283.1 ENST00000648742.1	GADD45A Ensembl NCBI GeneCards UniProt Show fit	growth arrest and DNA damage inducible alpha
chr3_-_142029108 Show fit	5.23	ENST00000497579.5	TFDP2 Ensembl NCBI GeneCards UniProt Show fit	transcription factor Dp-2
chr1_+_36155930 Show fit	5.18	ENST00000316156.8	MAP7D1 Ensembl NCBI GeneCards UniProt Show fit	MAP7 domain containing 1
chr1_-_151992571 Show fit	5.16	ENST00000368809.1	S100A10 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A10
chr6_-_109381739 Show fit	5.10	ENST00000504373.2	CD164 Ensembl NCBI GeneCards UniProt Show fit	CD164 molecule
chr4_+_128811264 Show fit	4.95	ENST00000610919.4 ENST00000510308.5	JADE1 Ensembl NCBI GeneCards UniProt Show fit	jade family PHD finger 1
chr3_-_57199938 Show fit	4.70	ENST00000473921.2 ENST00000295934.8	HESX1 Ensembl NCBI GeneCards UniProt Show fit	HESX homeobox 1
chr1_-_212791762 Show fit	4.45	ENST00000626725.1 ENST00000366977.8 ENST00000366976.3	NSL1 Ensembl NCBI GeneCards UniProt Show fit	NSL1 component of MIS12 kinetochore complex
chr15_+_58138368 Show fit	4.43	ENST00000219919.9 ENST00000536493.1	AQP9 Ensembl NCBI GeneCards UniProt Show fit	aquaporin 9
chr21_-_14546297 Show fit	4.40	ENST00000400566.6 ENST00000400564.5	SAMSN1 Ensembl NCBI GeneCards UniProt Show fit	SAM domain, SH3 domain and nuclear localization signals 1
chr11_-_33892010 Show fit	4.27	ENST00000257818.3	LMO2 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 2
chr15_+_80059651 Show fit	4.25	ENST00000561012.5 ENST00000261749.11 ENST00000564367.5 ENST00000558494.5	ZFAND6 Ensembl NCBI GeneCards UniProt Show fit	zinc finger AN1-type containing 6
chr2_+_108588286 Show fit	4.20	ENST00000332345.10	LIMS1 Ensembl NCBI GeneCards UniProt Show fit	LIM zinc finger domain containing 1
chr3_-_39280021 Show fit	4.09	ENST00000399220.3	CX3CR1 Ensembl NCBI GeneCards UniProt Show fit	C-X3-C motif chemokine receptor 1
chr12_-_86256299 Show fit	4.07	ENST00000552808.6 ENST00000547225.5	MGAT4C Ensembl NCBI GeneCards UniProt Show fit	MGAT4 family member C
chr7_-_101217569 Show fit	3.82	ENST00000223127.8	PLOD3 Ensembl NCBI GeneCards UniProt Show fit	procollagen-lysine,2-oxoglutarate 5-dioxygenase 3
chr6_+_13272709 Show fit	3.70	ENST00000379335.8	PHACTR1 Ensembl NCBI GeneCards UniProt Show fit	phosphatase and actin regulator 1
chr12_-_52573816 Show fit	3.61	ENST00000549343.5 ENST00000305620.3	KRT74 Ensembl NCBI GeneCards UniProt Show fit	keratin 74
chr10_+_47322450 Show fit	3.60	ENST00000581492.3	GDF2 Ensembl NCBI GeneCards UniProt Show fit	growth differentiation factor 2
chr1_+_100538131 Show fit	3.58	ENST00000315033.5	GPR88 Ensembl NCBI GeneCards UniProt Show fit	G protein-coupled receptor 88
chr11_-_8268716 Show fit	3.58	ENST00000428101.6	LMO1 Ensembl NCBI GeneCards UniProt Show fit	LIM domain only 1
chr4_+_1289870 Show fit	3.54	ENST00000505177.6 ENST00000503653.5 ENST00000264750.10 ENST00000303400.9 ENST00000502558.5 ENST00000514708.5	MAEA Ensembl NCBI GeneCards UniProt Show fit	macrophage erythroblast attacher, E3 ubiquitin ligase
chr3_-_55487295 Show fit	3.42	ENST00000264634.9	WNT5A Ensembl NCBI GeneCards UniProt Show fit	Wnt family member 5A
chr5_-_83720813 Show fit	3.37	ENST00000515590.1 ENST00000274341.9	HAPLN1 Ensembl NCBI GeneCards UniProt Show fit	hyaluronan and proteoglycan link protein 1
chr15_+_58987652 Show fit	3.31	ENST00000348370.9 ENST00000559160.1	RNF111 Ensembl NCBI GeneCards UniProt Show fit	ring finger protein 111
chr3_+_69936583 Show fit	3.15	ENST00000314557.10 ENST00000394351.9	MITF Ensembl NCBI GeneCards UniProt Show fit	melanocyte inducing transcription factor
chr14_-_89619118 Show fit	3.13	ENST00000345097.8 ENST00000555855.5 ENST00000555353.5	FOXN3 Ensembl NCBI GeneCards UniProt Show fit	forkhead box N3
chr18_-_55351977 Show fit	3.11	ENST00000643689.1	TCF4 Ensembl NCBI GeneCards UniProt Show fit	transcription factor 4
chr6_-_32190170 Show fit	3.08	ENST00000375050.6	PBX2 Ensembl NCBI GeneCards UniProt Show fit	PBX homeobox 2
chr1_-_1778399 Show fit	3.03	ENST00000341426.9	NADK Ensembl NCBI GeneCards UniProt Show fit	NAD kinase
chr1_-_1778790 Show fit	3.03	ENST00000341991.7	NADK Ensembl NCBI GeneCards UniProt Show fit	NAD kinase
chr21_-_34526850 Show fit	2.86	ENST00000481448.5 ENST00000381132.6	RCAN1 Ensembl NCBI GeneCards UniProt Show fit	regulator of calcineurin 1
chr7_-_116030750 Show fit	2.79	ENST00000265440.12 ENST00000320239.11	TFEC Ensembl NCBI GeneCards UniProt Show fit	transcription factor EC
chr19_+_49513353 Show fit	2.78	ENST00000596975.5	FCGRT Ensembl NCBI GeneCards UniProt Show fit	Fc fragment of IgG receptor and transporter
chr13_-_75366973 Show fit	2.75	ENST00000648194.1	TBC1D4 Ensembl NCBI GeneCards UniProt Show fit	TBC1 domain family member 4
chr4_-_115113614 Show fit	2.73	ENST00000264363.7	NDST4 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase and N-sulfotransferase 4
chr9_+_122370523 Show fit	2.71	ENST00000643810.1 ENST00000540753.6	PTGS1 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin-endoperoxide synthase 1
chr8_+_22567038 Show fit	2.69	ENST00000523348.1	SORBS3 Ensembl NCBI GeneCards UniProt Show fit	sorbin and SH3 domain containing 3
chr12_+_55932028 Show fit	2.65	ENST00000394147.5 ENST00000551156.5 ENST00000553783.5 ENST00000557080.5 ENST00000432422.7 ENST00000556001.5	DGKA Ensembl NCBI GeneCards UniProt Show fit	diacylglycerol kinase alpha
chr18_+_34593312 Show fit	2.63	ENST00000591816.6 ENST00000588125.5 ENST00000684610.1 ENST00000683705.1 ENST00000598334.5 ENST00000588684.5 ENST00000554864.7 ENST00000399121.9 ENST00000595022.5	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr4_+_56907876 Show fit	2.62	ENST00000640168.2 ENST00000309042.12	REST Ensembl NCBI GeneCards UniProt Show fit	RE1 silencing transcription factor
chr2_+_233718734 Show fit	2.59	ENST00000373409.8	UGT1A4 Ensembl NCBI GeneCards UniProt Show fit	UDP glucuronosyltransferase family 1 member A4
chr9_+_90827452 Show fit	2.55	ENST00000375746.1	SYK Ensembl NCBI GeneCards UniProt Show fit	spleen associated tyrosine kinase
chr15_+_90872862 Show fit	2.52	ENST00000618099.4	FURIN Ensembl NCBI GeneCards UniProt Show fit	furin, paired basic amino acid cleaving enzyme
chr6_-_41734160 Show fit	2.48	ENST00000424495.2 ENST00000420312.6	TFEB Ensembl NCBI GeneCards UniProt Show fit	transcription factor EB
chr4_+_168092530 Show fit	2.48	ENST00000359299.8	ANXA10 Ensembl NCBI GeneCards UniProt Show fit	annexin A10
chr5_-_141619049 Show fit	2.46	ENST00000647433.1 ENST00000253811.10 ENST00000389057.9 ENST00000398557.8	DIAPH1 Ensembl NCBI GeneCards UniProt Show fit	diaphanous related formin 1
chr7_-_24980148 Show fit	2.45	ENST00000313367.7	OSBPL3 Ensembl NCBI GeneCards UniProt Show fit	oxysterol binding protein like 3
chr4_-_65670339 Show fit	2.45	ENST00000273854.7	EPHA5 Ensembl NCBI GeneCards UniProt Show fit	EPH receptor A5
chr7_-_100119323 Show fit	2.43	ENST00000523306.5 ENST00000344095.8 ENST00000417349.5 ENST00000493322.5 ENST00000520135.5 ENST00000460673.2 ENST00000453269.7 ENST00000452041.5 ENST00000452438.6 ENST00000451699.5	TAF6 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 6
chr6_-_116060859 Show fit	2.38	ENST00000606080.2	FRK Ensembl NCBI GeneCards UniProt Show fit	fyn related Src family tyrosine kinase
chr18_+_61333424 Show fit	2.37	ENST00000262717.9	CDH20 Ensembl NCBI GeneCards UniProt Show fit	cadherin 20
chr12_-_32755876 Show fit	2.32	ENST00000324868.13	YARS2 Ensembl NCBI GeneCards UniProt Show fit	tyrosyl-tRNA synthetase 2
chr15_-_37101205 Show fit	2.31	ENST00000338564.9 ENST00000558313.5 ENST00000340545.9	MEIS2 Ensembl NCBI GeneCards UniProt Show fit	Meis homeobox 2
chr7_-_116030735 Show fit	2.26	ENST00000393485.5	TFEC Ensembl NCBI GeneCards UniProt Show fit	transcription factor EC
chr4_+_143433491 Show fit	2.26	ENST00000512843.1	GAB1 Ensembl NCBI GeneCards UniProt Show fit	GRB2 associated binding protein 1
chr12_-_54419259 Show fit	2.20	ENST00000293379.9	ITGA5 Ensembl NCBI GeneCards UniProt Show fit	integrin subunit alpha 5
chr7_-_151520080 Show fit	2.17	ENST00000496004.5	RHEB Ensembl NCBI GeneCards UniProt Show fit	Ras homolog, mTORC1 binding
chr4_-_115113822 Show fit	2.16	ENST00000613194.4	NDST4 Ensembl NCBI GeneCards UniProt Show fit	N-deacetylase and N-sulfotransferase 4
chr5_-_141618957 Show fit	2.14	ENST00000389054.8	DIAPH1 Ensembl NCBI GeneCards UniProt Show fit	diaphanous related formin 1
chr4_-_65670478 Show fit	2.10	ENST00000613740.5 ENST00000622150.4 ENST00000511294.1	EPHA5 Ensembl NCBI GeneCards UniProt Show fit	EPH receptor A5
chr1_-_68232514 Show fit	2.04	ENST00000262348.9 ENST00000370973.2 ENST00000370971.1	WLS Ensembl NCBI GeneCards UniProt Show fit	Wnt ligand secretion mediator
chr7_+_50308672 Show fit	2.01	ENST00000439701.2 ENST00000438033.5 ENST00000492782.6	IKZF1 Ensembl NCBI GeneCards UniProt Show fit	IKAROS family zinc finger 1
chr4_-_39977836 Show fit	2.00	ENST00000303538.13 ENST00000503396.5	PDS5A Ensembl NCBI GeneCards UniProt Show fit	PDS5 cohesin associated factor A
chr8_-_42501224 Show fit	1.98	ENST00000520262.6 ENST00000517366.1	SLC20A2 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 20 member 2
chr9_+_122371036 Show fit	1.96	ENST00000619306.5 ENST00000426608.6 ENST00000223423.8	PTGS1 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin-endoperoxide synthase 1
chr6_+_167291309 Show fit	1.95	ENST00000230256.8	UNC93A Ensembl NCBI GeneCards UniProt Show fit	unc-93 homolog A
chr9_+_122371014 Show fit	1.94	ENST00000362012.7	PTGS1 Ensembl NCBI GeneCards UniProt Show fit	prostaglandin-endoperoxide synthase 1
chr3_+_122055355 Show fit	1.92	ENST00000330540.7 ENST00000469710.5 ENST00000493101.5	CD86 Ensembl NCBI GeneCards UniProt Show fit	CD86 molecule
chr6_-_41733690 Show fit	1.89	ENST00000419396.6 ENST00000678831.1 ENST00000394283.5	TFEB Ensembl NCBI GeneCards UniProt Show fit	transcription factor EB
chr18_+_34593392 Show fit	1.84	ENST00000684377.1	DTNA Ensembl NCBI GeneCards UniProt Show fit	dystrobrevin alpha
chr3_+_108822778 Show fit	1.67	ENST00000295756.11	TRAT1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor associated transmembrane adaptor 1
chr4_+_30720348 Show fit	1.65	ENST00000361762.3	PCDH7 Ensembl NCBI GeneCards UniProt Show fit	protocadherin 7
chr4_-_154612635 Show fit	1.59	ENST00000407946.5 ENST00000405164.5 ENST00000336098.8 ENST00000393846.6 ENST00000404648.7 ENST00000443553.5	FGG Ensembl NCBI GeneCards UniProt Show fit	fibrinogen gamma chain
chr12_-_85836372 Show fit	1.58	ENST00000361228.5	RASSF9 Ensembl NCBI GeneCards UniProt Show fit	Ras association domain family member 9
chr7_+_129375643 Show fit	1.53	ENST00000490911.5	AHCYL2 Ensembl NCBI GeneCards UniProt Show fit	adenosylhomocysteinase like 2
chr11_-_102625332 Show fit	1.51	ENST00000260228.3	MMP20 Ensembl NCBI GeneCards UniProt Show fit	matrix metallopeptidase 20
chr12_-_86256267 Show fit	1.49	ENST00000620241.4	MGAT4C Ensembl NCBI GeneCards UniProt Show fit	MGAT4 family member C
chr12_-_14696571 Show fit	1.49	ENST00000261170.5	GUCY2C Ensembl NCBI GeneCards UniProt Show fit	guanylate cyclase 2C
chr9_+_133636355 Show fit	1.48	ENST00000393056.8	DBH Ensembl NCBI GeneCards UniProt Show fit	dopamine beta-hydroxylase
chr4_-_138242325 Show fit	1.47	ENST00000280612.9	SLC7A11 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 7 member 11
chr6_+_31655888 Show fit	1.46	ENST00000375916.4	APOM Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein M
chr15_-_31101707 Show fit	1.46	ENST00000397795.6 ENST00000256552.11 ENST00000559179.2	TRPM1 Ensembl NCBI GeneCards UniProt Show fit	transient receptor potential cation channel subfamily M member 1
chr6_+_167291329 Show fit	1.42	ENST00000366829.2	UNC93A Ensembl NCBI GeneCards UniProt Show fit	unc-93 homolog A
chr3_-_165078480 Show fit	1.42	ENST00000264382.8	SI Ensembl NCBI GeneCards UniProt Show fit	sucrase-isomaltase
chr4_-_122456725 Show fit	1.40	ENST00000226730.5	IL2 Ensembl NCBI GeneCards UniProt Show fit	interleukin 2
chr1_-_68232539 Show fit	1.37	ENST00000370976.7 ENST00000354777.6	WLS Ensembl NCBI GeneCards UniProt Show fit	Wnt ligand secretion mediator
chr3_+_108822759 Show fit	1.29	ENST00000426646.1	TRAT1 Ensembl NCBI GeneCards UniProt Show fit	T cell receptor associated transmembrane adaptor 1
chr7_-_81770039 Show fit	1.28	ENST00000222390.11 ENST00000453411.6 ENST00000457544.7 ENST00000444829.7	HGF Ensembl NCBI GeneCards UniProt Show fit	hepatocyte growth factor
chr21_-_34526815 Show fit	1.25	ENST00000492600.1	RCAN1 Ensembl NCBI GeneCards UniProt Show fit	regulator of calcineurin 1
chr19_+_15082211 Show fit	1.23	ENST00000641398.1	OR1I1 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 1 subfamily I member 1
chr18_+_34978244 Show fit	1.04	ENST00000436190.6	MAPRE2 Ensembl NCBI GeneCards UniProt Show fit	microtubule associated protein RP/EB family member 2
chr10_-_13707536 Show fit	1.03	ENST00000632570.1 ENST00000477221.2	FRMD4A Ensembl NCBI GeneCards UniProt Show fit	FERM domain containing 4A
chrX_-_64976500 Show fit	1.00	ENST00000447788.6	ZC4H2 Ensembl NCBI GeneCards UniProt Show fit	zinc finger C4H2-type containing
chr20_+_61599755 Show fit	0.99	ENST00000543233.2	CDH4 Ensembl NCBI GeneCards UniProt Show fit	cadherin 4
chr12_-_52777343 Show fit	0.95	ENST00000332411.2	KRT76 Ensembl NCBI GeneCards UniProt Show fit	keratin 76
chr3_+_69936629 Show fit	0.94	ENST00000394348.2 ENST00000531774.1	MITF Ensembl NCBI GeneCards UniProt Show fit	melanocyte inducing transcription factor
chr6_-_29431967 Show fit	0.91	ENST00000377154.1 ENST00000641152.2	OR5V1 Ensembl NCBI GeneCards UniProt Show fit OR11A1 Ensembl NCBI GeneCards UniProt Show fit	olfactory receptor family 5 subfamily V member 1 olfactory receptor family 11 subfamily A member 1
chr17_-_7080275 Show fit	0.90	ENST00000571664.1 ENST00000254868.8	CLEC10A Ensembl NCBI GeneCards UniProt Show fit	C-type lectin domain containing 10A
chr18_+_58341038 Show fit	0.89	ENST00000679791.1	NEDD4L Ensembl NCBI GeneCards UniProt Show fit	NEDD4 like E3 ubiquitin protein ligase
chr8_+_32721823 Show fit	0.85	ENST00000539990.3 ENST00000519240.5	NRG1 Ensembl NCBI GeneCards UniProt Show fit	neuregulin 1
chr3_-_108529322 Show fit	0.83	ENST00000273353.4	MYH15 Ensembl NCBI GeneCards UniProt Show fit	myosin heavy chain 15
chr1_-_93681829 Show fit	0.80	ENST00000260502.11	BCAR3 Ensembl NCBI GeneCards UniProt Show fit	BCAR3 adaptor protein, NSP family member
chr20_+_64164446 Show fit	0.75	ENST00000328439.6	MYT1 Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1
chr12_-_121016345 Show fit	0.71	ENST00000535367.1 ENST00000538296.5 ENST00000288757.7 ENST00000539736.5 ENST00000537817.5	C12orf43 Ensembl NCBI GeneCards UniProt Show fit	chromosome 12 open reading frame 43
chr7_-_100119840 Show fit	0.69	ENST00000437822.6	TAF6 Ensembl NCBI GeneCards UniProt Show fit	TATA-box binding protein associated factor 6
chrX_-_18672101 Show fit	0.67	ENST00000379984.4	RS1 Ensembl NCBI GeneCards UniProt Show fit	retinoschisin 1
chr6_-_110815152 Show fit	0.60	ENST00000413605.6	CDK19 Ensembl NCBI GeneCards UniProt Show fit	cyclin dependent kinase 19
chr15_+_48206286 Show fit	0.60	ENST00000396577.7 ENST00000380993.8	SLC12A1 Ensembl NCBI GeneCards UniProt Show fit	solute carrier family 12 member 1
chr1_-_151459169 Show fit	0.59	ENST00000368863.6 ENST00000409503.5 ENST00000491586.5 ENST00000533351.5	POGZ Ensembl NCBI GeneCards UniProt Show fit	pogo transposable element derived with ZNF domain
chr18_+_31318144 Show fit	0.54	ENST00000257192.5	DSG1 Ensembl NCBI GeneCards UniProt Show fit	desmoglein 1
chr7_-_81770122 Show fit	0.50	ENST00000423064.7	HGF Ensembl NCBI GeneCards UniProt Show fit	hepatocyte growth factor
chr12_+_15546344 Show fit	0.47	ENST00000674388.1 ENST00000542557.5 ENST00000445537.6 ENST00000544244.5 ENST00000442921.7	PTPRO Ensembl NCBI GeneCards UniProt Show fit	protein tyrosine phosphatase receptor type O
chr20_+_44401222 Show fit	0.47	ENST00000316099.9	HNF4A Ensembl NCBI GeneCards UniProt Show fit	hepatocyte nuclear factor 4 alpha
chr15_-_72271244 Show fit	0.47	ENST00000287196.13	PARP6 Ensembl NCBI GeneCards UniProt Show fit	poly(ADP-ribose) polymerase family member 6
chr17_-_10026265 Show fit	0.44	ENST00000437099.6 ENST00000396115.6	GAS7 Ensembl NCBI GeneCards UniProt Show fit	growth arrest specific 7
chr5_+_170105892 Show fit	0.41	ENST00000306268.8 ENST00000449804.4	FOXI1 Ensembl NCBI GeneCards UniProt Show fit	forkhead box I1
chr17_-_41467386 Show fit	0.32	ENST00000225899.4	KRT32 Ensembl NCBI GeneCards UniProt Show fit	keratin 32
chr13_-_27171701 Show fit	0.32	ENST00000620323.1 ENST00000282344.11	USP12 Ensembl NCBI GeneCards UniProt Show fit	ubiquitin specific peptidase 12
chr4_-_41748713 Show fit	0.27	ENST00000226382.4	PHOX2B Ensembl NCBI GeneCards UniProt Show fit	paired like homeobox 2B
chr7_+_138460238 Show fit	0.26	ENST00000343526.9	TRIM24 Ensembl NCBI GeneCards UniProt Show fit	tripartite motif containing 24
chrX_+_16946650 Show fit	0.25	ENST00000357277.8	REPS2 Ensembl NCBI GeneCards UniProt Show fit	RALBP1 associated Eps domain containing 2
chr13_-_79406175 Show fit	0.21	ENST00000438724.5 ENST00000622611.4 ENST00000438737.3	RBM26 Ensembl NCBI GeneCards UniProt Show fit	RNA binding motif protein 26
chr1_-_94121105 Show fit	0.20	ENST00000649773.1 ENST00000370225.4	ABCA4 Ensembl NCBI GeneCards UniProt Show fit	ATP binding cassette subfamily A member 4
chr20_+_64164566 Show fit	0.13	ENST00000650655.1	MYT1 Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1
chrX_-_64976435 Show fit	0.12	ENST00000374839.8	ZC4H2 Ensembl NCBI GeneCards UniProt Show fit	zinc finger C4H2-type containing
chr4_-_69653223 Show fit	0.10	ENST00000286604.8 ENST00000505512.1 ENST00000514019.1	UGT2A1 Ensembl NCBI GeneCards UniProt Show fit	UDP glucuronosyltransferase family 2 member A1 complex locus
chr20_+_64164474 Show fit	0.00	ENST00000622439.4 ENST00000536311.5	MYT1 Ensembl NCBI GeneCards UniProt Show fit	myelin transcription factor 1

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
9.6	57.6	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
6.3	38.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
4.3	12.9	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
2.6	10.4	GO:0018201	N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
2.1	12.4	GO:1904721	negative regulation of mRNA cleavage(GO:0031438) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
1.9	5.6	GO:1903676	regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
1.7	8.4	GO:0051799	negative regulation of hair follicle development(GO:0051799)
1.6	19.4	GO:0090160	Golgi to lysosome transport(GO:0090160)
1.6	7.8	GO:1903904	negative regulation of establishment of T cell polarity(GO:1903904) negative regulation of Rho guanyl-nucleotide exchange factor activity(GO:2001107)
1.5	12.4	GO:0030091	protein repair(GO:0030091)
1.4	5.7	GO:0002501	peptide antigen assembly with MHC protein complex(GO:0002501)
1.2	6.1	GO:0006741	NADP biosynthetic process(GO:0006741)
1.1	3.4	GO:0060031	cardiac right atrium morphogenesis(GO:0003213) mediolateral intercalation(GO:0060031) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) planar cell polarity pathway involved in gastrula mediolateral intercalation(GO:0060775) regulation of cell proliferation in midbrain(GO:1904933)
1.1	3.4	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
1.1	22.3	GO:0071803	positive regulation of podosome assembly(GO:0071803)
1.1	4.4	GO:1904823	canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
1.1	51.9	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
1.1	9.7	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
1.0	4.1	GO:0002881	negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881)
1.0	3.8	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.0	4.8	GO:0046013	regulation of T cell homeostatic proliferation(GO:0046013)
0.9	2.8	GO:0002416	IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.9	2.6	GO:2000797	amniotic stem cell differentiation(GO:0097086) negative regulation of dense core granule biogenesis(GO:2000706) negative regulation of mesenchymal stem cell differentiation(GO:2000740) regulation of amniotic stem cell differentiation(GO:2000797) negative regulation of amniotic stem cell differentiation(GO:2000798)
0.9	12.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.8	7.5	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.7	8.8	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.7	5.8	GO:0001887	selenium compound metabolic process(GO:0001887)
0.6	1.9	GO:0032761	negative regulation of T cell tolerance induction(GO:0002665) negative regulation of T cell anergy(GO:0002668) negative regulation of lymphocyte anergy(GO:0002912) regulation of lymphotoxin A production(GO:0032681) positive regulation of lymphotoxin A production(GO:0032761) regulation of lymphotoxin A biosynthetic process(GO:0043016) positive regulation of lymphotoxin A biosynthetic process(GO:0043017)
0.6	2.5	GO:0043366	response to molecule of fungal origin(GO:0002238) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) beta selection(GO:0043366) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
0.6	2.5	GO:0019082	viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.6	6.8	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.6	7.2	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6	3.6	GO:0061743	motor learning(GO:0061743)
0.6	17.5	GO:0072663	protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.5	3.0	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.5	14.4	GO:0043555	regulation of translation in response to stress(GO:0043555)
0.4	12.9	GO:0050860	negative regulation of T cell receptor signaling pathway(GO:0050860)
0.4	3.3	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.4	2.8	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.4	5.0	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.4	10.7	GO:0034063	stress granule assembly(GO:0034063)
0.4	4.9	GO:0030210	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.4	1.5	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.4	3.5	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.3	2.3	GO:0070127	tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.3	6.6	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.3	1.8	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.3	4.7	GO:0030916	otic vesicle formation(GO:0030916)
0.3	5.2	GO:0001765	membrane raft assembly(GO:0001765)
0.2	1.5	GO:0042421	norepinephrine biosynthetic process(GO:0042421)
0.2	5.5	GO:0006418	tRNA aminoacylation for protein translation(GO:0006418)
0.2	5.3	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.2	5.5	GO:0031063	regulation of histone deacetylation(GO:0031063)
0.2	2.2	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.2	1.5	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.2	4.6	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.2	2.6	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2	1.4	GO:0044245	polysaccharide digestion(GO:0044245)
0.2	21.1	GO:0090630	activation of GTPase activity(GO:0090630)
0.2	2.0	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.2	4.3	GO:0042789	mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2	11.4	GO:0046579	positive regulation of Ras protein signal transduction(GO:0046579)
0.2	2.2	GO:0035372	protein localization to microtubule(GO:0035372)
0.1	7.0	GO:0042149	cellular response to glucose starvation(GO:0042149)
0.1	0.3	GO:0003358	noradrenergic neuron development(GO:0003358)
0.1	1.5	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1	4.1	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.1	5.8	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.1	5.5	GO:0006376	mRNA splice site selection(GO:0006376)
0.1	3.1	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.1	0.5	GO:0036058	filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.1	5.2	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1	4.4	GO:0050869	negative regulation of B cell activation(GO:0050869)
0.1	2.4	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.1	2.1	GO:0007064	mitotic sister chromatid cohesion(GO:0007064)
0.1	2.7	GO:0046339	diacylglycerol metabolic process(GO:0046339)
0.1	4.1	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1	1.5	GO:0070170	regulation of tooth mineralization(GO:0070170)
0.1	1.5	GO:0046548	retinal rod cell development(GO:0046548)
0.1	2.3	GO:0035728	response to hepatocyte growth factor(GO:0035728)
0.1	8.6	GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436)
0.1	12.1	GO:0002062	chondrocyte differentiation(GO:0002062)
0.1	12.9	GO:0002377	immunoglobulin production(GO:0002377)
0.1	1.9	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.1	0.9	GO:0048733	sebaceous gland development(GO:0048733)
0.1	4.4	GO:0080171	lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.1	9.0	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1	3.6	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.1	3.1	GO:0007274	neuromuscular synaptic transmission(GO:0007274)
0.1	2.5	GO:0006699	bile acid biosynthetic process(GO:0006699)
0.1	0.7	GO:0009642	response to light intensity(GO:0009642)
0.1	0.3	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	1.1	GO:0021522	spinal cord motor neuron differentiation(GO:0021522)
0.0	1.0	GO:0090162	establishment of epithelial cell polarity(GO:0090162)
0.0	1.1	GO:0035094	response to nicotine(GO:0035094)
0.0	6.6	GO:0030705	cytoskeleton-dependent intracellular transport(GO:0030705)
0.0	2.3	GO:0008542	visual learning(GO:0008542)
0.0	4.4	GO:0000070	mitotic sister chromatid segregation(GO:0000070)
0.0	3.1	GO:0042795	snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	2.4	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
0.0	0.5	GO:0032570	response to progesterone(GO:0032570)
0.0	10.7	GO:0042493	response to drug(GO:0042493)
0.0	3.0	GO:0030307	positive regulation of cell growth(GO:0030307)
0.0	2.9	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.0	0.1	GO:0052695	cellular glucuronidation(GO:0052695)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
3.4	44.3	GO:0033093	Weibel-Palade body(GO:0033093)
1.8	5.5	GO:0017102	methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.2	3.5	GO:0034657	GID complex(GO:0034657)
0.9	16.1	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.9	5.7	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.9	22.3	GO:0001891	phagocytic cup(GO:0001891)
0.8	12.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.7	4.4	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.7	2.2	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.7	7.8	GO:0060171	stereocilium membrane(GO:0060171)
0.5	2.5	GO:0019815	B cell receptor complex(GO:0019815)
0.4	1.5	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
0.4	1.5	GO:0035841	new growing cell tip(GO:0035841)
0.3	5.5	GO:0000812	Swr1 complex(GO:0000812)
0.3	8.6	GO:0005839	proteasome core complex(GO:0005839)
0.2	43.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	1.6	GO:0005577	fibrinogen complex(GO:0005577)
0.2	3.1	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.2	7.5	GO:0031258	lamellipodium membrane(GO:0031258)
0.2	2.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.2	2.5	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.1	1.5	GO:0042584	chromaffin granule membrane(GO:0042584)
0.1	4.1	GO:0044298	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.1	18.5	GO:0005604	basement membrane(GO:0005604)
0.1	10.7	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.1	3.8	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.1	3.4	GO:0032839	dendrite cytoplasm(GO:0032839)
0.1	3.4	GO:0030669	clathrin-coated endocytic vesicle membrane(GO:0030669)
0.1	3.0	GO:0042101	T cell receptor complex(GO:0042101)
0.1	5.8	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.1	4.1	GO:0030140	trans-Golgi network transport vesicle(GO:0030140)
0.1	9.5	GO:0009898	cytoplasmic side of plasma membrane(GO:0009898)
0.1	1.5	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	1.0	GO:0035371	microtubule plus-end(GO:0035371)
0.1	10.4	GO:0019898	extrinsic component of membrane(GO:0019898)
0.1	3.3	GO:0045095	keratin filament(GO:0045095)
0.1	1.6	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	35.2	GO:0010008	endosome membrane(GO:0010008)
0.1	4.8	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.1	0.3	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	5.0	GO:0000123	histone acetyltransferase complex(GO:0000123)
0.1	15.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.0	16.8	GO:0005819	spindle(GO:0005819)
0.0	5.3	GO:0044309	dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0	10.8	GO:0005874	microtubule(GO:0005874)
0.0	0.8	GO:0032982	myosin filament(GO:0032982)
0.0	2.5	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	3.3	GO:0016605	PML body(GO:0016605)
0.0	10.1	GO:0016607	nuclear speck(GO:0016607)
0.0	3.1	GO:0032993	protein-DNA complex(GO:0032993)
0.0	1.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	63.4	GO:0005654	nucleoplasm(GO:0005654)
0.0	1.4	GO:0005667	transcription factor complex(GO:0005667)
0.0	1.4	GO:0005903	brush border(GO:0005903)
0.0	0.3	GO:0000790	nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	10.4	GO:0019107	glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
2.5	12.4	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
2.2	57.6	GO:0031489	myosin V binding(GO:0031489)
1.9	9.7	GO:0004883	glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
1.8	12.4	GO:0060698	endoribonuclease inhibitor activity(GO:0060698)
1.5	4.4	GO:0015265	urea channel activity(GO:0015265)
1.4	38.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
1.3	6.6	GO:0004666	prostaglandin-endoperoxide synthase activity(GO:0004666)
1.1	51.9	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
1.0	4.1	GO:0016495	C-X3-C chemokine receptor activity(GO:0016495)
1.0	10.7	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
1.0	3.8	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) procollagen galactosyltransferase activity(GO:0050211)
0.9	5.6	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.8	3.3	GO:0032184	SUMO polymer binding(GO:0032184)
0.8	5.7	GO:0001849	complement component C1q binding(GO:0001849)
0.8	5.6	GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.7	3.6	GO:1990254	keratin filament binding(GO:1990254)
0.7	4.9	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.7	2.8	GO:0019770	IgG receptor activity(GO:0019770)
0.5	4.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.4	13.4	GO:0019198	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.4	14.3	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.4	7.2	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.4	2.0	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.4	12.1	GO:0070034	telomerase RNA binding(GO:0070034)
0.4	4.6	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.4	11.3	GO:0070410	co-SMAD binding(GO:0070410)
0.4	7.5	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.3	8.6	GO:0070628	proteasome binding(GO:0070628)
0.3	17.5	GO:0031593	polyubiquitin binding(GO:0031593)
0.3	8.7	GO:0003951	NAD+ kinase activity(GO:0003951)
0.3	1.5	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.3	14.4	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3	1.4	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.3	1.4	GO:0043208	glycosphingolipid binding(GO:0043208)
0.3	1.5	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.2	1.5	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.2	2.2	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.2	3.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.2	0.6	GO:0008511	sodium:potassium:chloride symporter activity(GO:0008511)
0.2	7.8	GO:0000049	tRNA binding(GO:0000049)
0.2	3.0	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.2	3.4	GO:0048018	receptor agonist activity(GO:0048018)
0.2	2.5	GO:0048406	nerve growth factor binding(GO:0048406)
0.2	6.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.2	2.5	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2	2.0	GO:0015643	toxic substance binding(GO:0015643)
0.2	5.9	GO:0046875	ephrin receptor binding(GO:0046875)
0.2	9.0	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1	3.1	GO:0001087	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	4.3	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.1	2.6	GO:0015271	outward rectifier potassium channel activity(GO:0015271)
0.1	3.4	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.1	4.4	GO:0001784	phosphotyrosine binding(GO:0001784)
0.1	5.5	GO:0036002	pre-mRNA binding(GO:0036002)
0.1	17.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.1	5.0	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	2.7	GO:0017166	vinculin binding(GO:0017166)
0.1	5.5	GO:0031491	nucleosome binding(GO:0031491)
0.1	6.8	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1	0.7	GO:0070492	oligosaccharide binding(GO:0070492)
0.1	1.7	GO:0005540	hyaluronic acid binding(GO:0005540)
0.1	2.6	GO:0001972	retinoic acid binding(GO:0001972)
0.1	5.0	GO:0050840	extracellular matrix binding(GO:0050840)
0.1	2.5	GO:0015248	sterol transporter activity(GO:0015248)
0.1	2.4	GO:0071889	14-3-3 protein binding(GO:0071889)
0.1	20.4	GO:0030246	carbohydrate binding(GO:0030246)
0.1	0.2	GO:0090555	phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.1	14.3	GO:0003823	antigen binding(GO:0003823)
0.0	9.1	GO:0001047	core promoter binding(GO:0001047)
0.0	2.5	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	18.8	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	12.8	GO:0051020	GTPase binding(GO:0051020)
0.0	2.4	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0	4.4	GO:0003774	motor activity(GO:0003774)
0.0	1.6	GO:0005160	transforming growth factor beta receptor binding(GO:0005160)
0.0	4.8	GO:0003924	GTPase activity(GO:0003924)
0.0	1.5	GO:0016209	antioxidant activity(GO:0016209)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.8	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	1.5	GO:0005262	calcium channel activity(GO:0005262)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	51.9	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.7	52.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.5	16.9	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	20.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.3	14.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.2	9.0	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.2	5.6	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.2	14.1	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	4.6	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	9.7	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	3.6	PID ALK1 PATHWAY	ALK1 signaling events
0.1	14.4	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.1	6.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.1	6.8	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	10.5	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	3.4	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	4.0	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.1	4.7	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1	2.8	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.1	4.1	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.1	6.4	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	5.2	PID E2F PATHWAY	E2F transcription factor network
0.0	2.5	PID NOTCH PATHWAY	Notch signaling pathway
0.0	0.8	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
2.2	55.9	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
2.1	51.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.4	51.9	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.6	5.5	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.5	7.5	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.4	5.7	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4	18.5	REACTOME AMYLOIDS	Genes involved in Amyloids
0.4	8.8	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.4	10.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.3	4.4	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.3	11.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2	5.6	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.2	6.6	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	5.6	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.2	9.7	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.2	1.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.2	4.9	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.1	7.0	REACTOME ERK MAPK TARGETS	Genes involved in ERK/MAPK targets
0.1	2.3	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.1	2.5	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	8.6	REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1	Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.1	2.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.1	1.8	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.1	4.2	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	3.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.1	1.4	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.1	2.7	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	1.9	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.1	2.5	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.1	3.1	REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING	Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1	12.1	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	6.6	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	1.4	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	2.7	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	1.0	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	2.2	REACTOME SIGNAL TRANSDUCTION BY L1	Genes involved in Signal transduction by L1
0.0	4.4	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	2.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	2.5	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.8	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	1.5	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	3.4	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.0	0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants

Results for PDX1

Z-value: 0.82

Motif logo

Transcription factors associated with PDX1

Activity-expression correlation:

Activity profile of PDX1 motif

Sorted Z-values of PDX1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of PDX1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: