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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PGR
Z-value: 0.81
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Transcription factors associated with PGR
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PGR | hg38_v1_chr11_-_101129806_101129822 | 0.25 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PGR
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_87529359 Show fit | 29.32 |
ENST00000458304.2
ENST00000282470.11 |
SPARC like 1 |
|
| chr4_-_87529460 Show fit | 29.28 |
ENST00000418378.5
|
SPARC like 1 |
|
| chr3_-_114624921 Show fit | 14.76 |
ENST00000393785.6
|
zinc finger and BTB domain containing 20 |
|
| chr3_-_114624979 Show fit | 14.72 |
ENST00000676079.1
|
zinc finger and BTB domain containing 20 |
|
| chr18_+_31591869 Show fit | 10.83 |
ENST00000237014.8
|
transthyretin |
|
| chr3_-_114624193 Show fit | 10.10 |
ENST00000481632.5
|
zinc finger and BTB domain containing 20 |
|
| chr14_+_24171853 Show fit | 9.20 |
ENST00000620473.4
ENST00000557806.5 ENST00000611366.5 |
REC8 meiotic recombination protein |
|
| chr12_+_78864768 Show fit | 9.02 |
ENST00000261205.9
ENST00000457153.6 |
synaptotagmin 1 |
|
| chr19_-_6720641 Show fit | 8.72 |
ENST00000245907.11
|
complement C3 |
|
| chr17_-_58544315 Show fit | 8.58 |
ENST00000671766.1
ENST00000672673.2 ENST00000321691.3 |
septin 4 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 53.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 0.7 | 39.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 1.2 | 19.6 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 5.9 | 17.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.8 | 10.8 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.6 | 10.1 | GO:0001542 | ovulation from ovarian follicle(GO:0001542) |
| 0.3 | 9.4 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 9.3 | GO:2000257 | regulation of complement activation(GO:0030449) regulation of protein activation cascade(GO:2000257) |
| 0.5 | 9.2 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 0.2 | 9.1 | GO:0050829 | defense response to Gram-negative bacterium(GO:0050829) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 69.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 26.1 | GO:0030426 | growth cone(GO:0030426) |
| 3.5 | 17.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 9.9 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 9.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 3.1 | 9.2 | GO:0034991 | nuclear meiotic cohesin complex(GO:0034991) |
| 0.7 | 8.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 7.5 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.0 | 7.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 6.8 | GO:0043218 | compact myelin(GO:0043218) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 59.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 42.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 20.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 3.5 | 17.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.1 | 12.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.7 | 10.8 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.3 | 10.2 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.4 | 9.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.3 | 9.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.3 | 9.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 74.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 22.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 9.4 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 8.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 5.4 | PID ATR PATHWAY | ATR signaling pathway |
| 0.1 | 5.4 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.0 | 4.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 4.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 17.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.3 | 14.1 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 14.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 10.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 9.9 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.8 | 9.8 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.2 | 9.2 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.5 | 8.7 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.5 | 8.6 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.3 | 7.8 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |