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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PITX2
Z-value: 0.40
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Transcription factors associated with PITX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX2 | hg38_v1_chr4_-_110636963_110637042, hg38_v1_chr4_-_110641920_110642123, hg38_v1_chr4_-_110623051_110623085 | -0.11 | 1.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_35855627 Show fit | 10.13 |
ENST00000379893.5
|
doublecortin like kinase 1 |
|
| chr11_-_5227063 Show fit | 8.16 |
ENST00000335295.4
ENST00000485743.1 ENST00000647020.1 |
hemoglobin subunit beta |
|
| chr13_-_35855758 Show fit | 5.97 |
ENST00000615680.4
|
doublecortin like kinase 1 |
|
| chr11_-_133532493 Show fit | 5.14 |
ENST00000524381.6
|
opioid binding protein/cell adhesion molecule like |
|
| chr4_-_101347492 Show fit | 4.90 |
ENST00000394854.8
|
protein phosphatase 3 catalytic subunit alpha |
|
| chr4_-_101347327 Show fit | 4.52 |
ENST00000394853.8
|
protein phosphatase 3 catalytic subunit alpha |
|
| chr3_+_159069252 Show fit | 4.14 |
ENST00000640015.1
ENST00000476809.7 ENST00000485419.7 |
IQCJ-SCHIP1 readthrough |
|
| chr4_-_101347471 Show fit | 3.98 |
ENST00000323055.10
ENST00000512215.5 |
protein phosphatase 3 catalytic subunit alpha |
|
| chr4_-_101346842 Show fit | 3.98 |
ENST00000507176.5
|
protein phosphatase 3 catalytic subunit alpha |
|
| chr12_-_89656051 Show fit | 3.51 |
ENST00000261173.6
|
ATPase plasma membrane Ca2+ transporting 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 17.4 | GO:1905205 | positive regulation of connective tissue replacement(GO:1905205) |
| 0.3 | 16.3 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 2.7 | 8.2 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 1.2 | 6.9 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.1 | 5.1 | GO:0008038 | neuron recognition(GO:0008038) |
| 0.2 | 2.3 | GO:0097105 | presynaptic membrane assembly(GO:0097105) |
| 0.0 | 2.1 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.2 | 1.7 | GO:0032286 | central nervous system myelin maintenance(GO:0032286) |
| 0.1 | 1.6 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.4 | 1.5 | GO:0072658 | maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 1.6 | 17.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 2.0 | 8.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.3 | 6.9 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 5.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 1.5 | GO:0043194 | spectrin-associated cytoskeleton(GO:0014731) axon initial segment(GO:0043194) |
| 0.0 | 0.2 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 0.1 | GO:0036157 | outer dynein arm(GO:0036157) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.7 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 1.9 | 17.4 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 1.2 | 8.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.2 | 6.9 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 2.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 2.1 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 2.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 0.9 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.8 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.0 | 0.8 | GO:0030507 | spectrin binding(GO:0030507) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 5.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.9 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.2 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.4 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 8.2 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.0 | 1.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 1.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 0.4 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.0 | 0.2 | REACTOME OPSINS | Genes involved in Opsins |