Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for PITX3
Z-value: 1.67
Motif logo
Transcription factors associated with PITX3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PITX3 | hg38_v1_chr10_-_102241502_102241517 | -0.67 | 7.8e-30 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PITX3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 186.7 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.6 | 153.9 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 6.0 | 84.7 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 1.9 | 79.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 7.6 | 68.0 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 12.6 | 62.8 | GO:0071163 | DNA replication preinitiation complex assembly(GO:0071163) |
| 1.3 | 59.4 | GO:0006301 | postreplication repair(GO:0006301) |
| 5.4 | 59.0 | GO:0000056 | ribosomal small subunit export from nucleus(GO:0000056) |
| 7.8 | 54.7 | GO:0097577 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 1.4 | 54.7 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 99.1 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.5 | 86.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 6.5 | 84.7 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.7 | 81.0 | GO:0005604 | basement membrane(GO:0005604) |
| 1.3 | 80.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 5.4 | 75.7 | GO:0019774 | proteasome core complex, beta-subunit complex(GO:0019774) |
| 0.3 | 69.2 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 11.3 | 68.0 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.5 | 63.3 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 3.9 | 63.0 | GO:0005642 | annulate lamellae(GO:0005642) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 232.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.2 | 214.4 | GO:0003723 | RNA binding(GO:0003723) |
| 0.9 | 105.2 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.5 | 90.7 | GO:0051015 | actin filament binding(GO:0051015) |
| 2.6 | 90.6 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 3.2 | 88.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.6 | 74.6 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.6 | 70.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 1.6 | 63.8 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 3.3 | 62.0 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 106.1 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.7 | 80.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 1.2 | 70.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 2.6 | 59.0 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.7 | 58.0 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 1.1 | 47.5 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.5 | 45.9 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 44.1 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.4 | 42.6 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.3 | 42.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 218.3 | REACTOME TRANSLATION | Genes involved in Translation |
| 2.5 | 211.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.6 | 163.7 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 4.4 | 142.0 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 2.9 | 117.6 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.8 | 96.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.5 | 86.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 2.9 | 82.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 1.3 | 72.7 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.7 | 66.0 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |